UniProtKB - A9N1Y3 (PEPB_SALPB)
Protein
Peptidase B
Gene
pepB
Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Functioni
Probably plays an important role in intracellular peptide degradation.UniRule annotation
Catalytic activityi
- Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.UniRule annotation EC:3.4.11.23
Cofactori
Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 195 | Manganese 2UniRule annotation | 1 | |
Metal bindingi | 200 | Manganese 1UniRule annotation | 1 | |
Metal bindingi | 200 | Manganese 2UniRule annotation | 1 | |
Active sitei | 207 | UniRule annotation | 1 | |
Metal bindingi | 218 | Manganese 2UniRule annotation | 1 | |
Metal bindingi | 277 | Manganese 1UniRule annotation | 1 | |
Metal bindingi | 279 | Manganese 1UniRule annotation | 1 | |
Metal bindingi | 279 | Manganese 2UniRule annotation | 1 | |
Active sitei | 281 | UniRule annotation | 1 |
GO - Molecular functioni
- manganese ion binding Source: UniProtKB-UniRule
- metalloaminopeptidase activity Source: InterPro
- transcription regulatory region sequence-specific DNA binding Source: InterPro
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BioCyci | SENT1016998:SPAB_RS01635-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidase BUniRule annotation (EC:3.4.11.23UniRule annotation)Alternative name(s): Aminopeptidase BUniRule annotation |
Gene namesi | Name:pepBUniRule annotation Ordered Locus Names:SPAB_00398 |
Organismi | Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) |
Taxonomic identifieri | 1016998 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000081511 | 1 – 427 | Peptidase BAdd BLAST | 427 |
Interactioni
Subunit structurei
Homohexamer.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the peptidase M17 family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_013734_7_1_6 |
OMAi | EKSWAFW |
Family and domain databases
CDDi | cd00433, Peptidase_M17, 1 hit |
HAMAPi | MF_00504, Aminopeptidase_M17, 1 hit |
InterProi | View protein in InterPro IPR001346, Interferon_reg_fact_DNA-bd_dom IPR011356, Leucine_aapep/pepB IPR008330, Pept_M17_PepB IPR000819, Peptidase_M17_C |
PANTHERi | PTHR11963, PTHR11963, 1 hit PTHR11963:SF20, PTHR11963:SF20, 1 hit |
Pfami | View protein in Pfam PF12404, DUF3663, 1 hit PF00883, Peptidase_M17, 1 hit |
PIRSFi | PIRSF036388, Ctsl_amnpptdse_B, 1 hit |
PRINTSi | PR00481, LAMNOPPTDASE |
PROSITEi | View protein in PROSITE PS00631, CYTOSOL_AP, 1 hit |
i Sequence
Sequence statusi: Complete.
A9N1Y3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEAMKITLS TQPADARWGD KATYSINNDG ITLHLNGKDD LGLIQRAARK
60 70 80 90 100
IDGLGIKQVA LTGEGWDTER CWAFWAGYKG PKGVRTVMWP DLDDAQRQEL
110 120 130 140 150
DNRLTIIDWV RDTINAPAEE LGPEQLAQRA VDLLCSVACD SVTYRITKGE
160 170 180 190 200
DLREQNYMGL HTVGRGSERP PVLLALDYNP TGDKDAPVYA CLVGKGITFD
210 220 230 240 250
SGGYSIKQSA FMDSMKSDMG GAATVTGALA FAITRGLNKR VKLFLCCADN
260 270 280 290 300
LISGNAFKLG DIIRYRNGKN VEVMNTDAEG RLVLADGLID ASAQHPQLII
310 320 330 340 350
DMATLTGAAK TALGNDYHAL FSFDDTLAGR LLTSAAQENE PFWRLPLAEF
360 370 380 390 400
HRNQLPSNFA ELNNTGSAAY PAGASTAAGF LSHFVENYRE GWLHIDCSAT
410 420
YRKAPVEQWA AGATGLGVRT IANLLTA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000886 Genomic DNA Translation: ABX65833.1 |
RefSeqi | WP_000133541.1, NC_010102.1 |
Genome annotation databases
EnsemblBacteriai | ABX65833; ABX65833; SPAB_00398 |
KEGGi | spq:SPAB_00398 |
PATRICi | fig|1016998.12.peg.376 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000886 Genomic DNA Translation: ABX65833.1 |
RefSeqi | WP_000133541.1, NC_010102.1 |
3D structure databases
SMRi | A9N1Y3 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ABX65833; ABX65833; SPAB_00398 |
KEGGi | spq:SPAB_00398 |
PATRICi | fig|1016998.12.peg.376 |
Phylogenomic databases
HOGENOMi | CLU_013734_7_1_6 |
OMAi | EKSWAFW |
Enzyme and pathway databases
BioCyci | SENT1016998:SPAB_RS01635-MONOMER |
Family and domain databases
CDDi | cd00433, Peptidase_M17, 1 hit |
HAMAPi | MF_00504, Aminopeptidase_M17, 1 hit |
InterProi | View protein in InterPro IPR001346, Interferon_reg_fact_DNA-bd_dom IPR011356, Leucine_aapep/pepB IPR008330, Pept_M17_PepB IPR000819, Peptidase_M17_C |
PANTHERi | PTHR11963, PTHR11963, 1 hit PTHR11963:SF20, PTHR11963:SF20, 1 hit |
Pfami | View protein in Pfam PF12404, DUF3663, 1 hit PF00883, Peptidase_M17, 1 hit |
PIRSFi | PIRSF036388, Ctsl_amnpptdse_B, 1 hit |
PRINTSi | PR00481, LAMNOPPTDASE |
PROSITEi | View protein in PROSITE PS00631, CYTOSOL_AP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PEPB_SALPB | |
Accessioni | A9N1Y3Primary (citable) accession number: A9N1Y3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries