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Protein

Cytochrome c-552

Gene

nrfA

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: nitrate reduction (assimilation)

This protein is involved in the pathway nitrate reduction (assimilation), which is part of Nitrogen metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway nitrate reduction (assimilation) and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi94Iron (heme 3 axial ligand)UniRule annotation1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei122Heme 1 (covalent)UniRule annotation1
Binding sitei125Heme 1 (covalent)UniRule annotation1
Metal bindingi126Iron (heme 1 axial ligand)UniRule annotation1
Binding sitei160Heme 2 (covalent)UniRule annotation1
Binding sitei163Heme 2 (covalent)UniRule annotation1
Metal bindingi164Iron (heme 2 axial ligand)UniRule annotation1
Binding sitei209Heme 3 (covalent)UniRule annotation1
Binding sitei212Heme 3 (covalent)UniRule annotation1
Metal bindingi213Iron (heme 3 axial ligand)UniRule annotation1
Metal bindingi215CalciumUniRule annotation1
Metal bindingi216Calcium; via carbonyl oxygenUniRule annotation1
Binding sitei216SubstrateUniRule annotation1
Metal bindingi261Calcium; via carbonyl oxygenUniRule annotation1
Metal bindingi263CalciumUniRule annotation1
Binding sitei264SubstrateUniRule annotation1
Metal bindingi275Iron (heme 5 axial ligand)UniRule annotation1
Binding sitei282Heme 4 (covalent)UniRule annotation1
Binding sitei285Heme 4 (covalent)UniRule annotation1
Metal bindingi286Iron (heme 4 axial ligand)UniRule annotation1
Metal bindingi301Iron (heme 2 axial ligand)UniRule annotation1
Binding sitei314Heme 5 (covalent)UniRule annotation1
Binding sitei317Heme 5 (covalent)UniRule annotation1
Metal bindingi318Iron (heme 5 axial ligand)UniRule annotation1
Metal bindingi393Iron (heme 4 axial ligand)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SENT1016998:SPAB_RS21465-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00653

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c-552UniRule annotation (EC:1.7.2.2UniRule annotation)
Alternative name(s):
Ammonia-forming cytochrome c nitrite reductaseUniRule annotation
Short name:
Cytochrome c nitrite reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nrfAUniRule annotation
Ordered Locus Names:SPAB_05272
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1016998 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26UniRule annotationAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_100008544927 – 478Cytochrome c-552Add BLAST452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A9N1R7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A9N1R7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c-552 family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000278511

KEGG Orthology (KO)

More...
KOi
K03385

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMVILWA

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01182 Cytochrom_C552, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003321 Cyt_c552
IPR017570 Cyt_c_NO2Rdtase_formate-dep
IPR011031 Multihaem_cyt
IPR036280 Multihaem_cyt_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30633 PTHR30633, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02335 Cytochrom_C552, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000243 Cyt_c552, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48695 SSF48695, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03152 cyto_c552_HCOOH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51008 MULTIHEME_CYTC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A9N1R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARKTLRARR FFSLIFPFFF ITSVYAEQTP ESAKTVTVEA KNEMFAPQHP
60 70 80 90 100
DQYQSWKATS EQSAREDALA EDPRLVILWA GYPFSRDYNK PRGHAYAVTD
110 120 130 140 150
VRETLRTGAP KTAEDGPLPM ACWSCKSPDV ARLIQQEGED GYFHGKWARG
160 170 180 190 200
GPEIVNDLGC ADCHNTASDD FAQGKPALTL SRPYAERAME AIGKPFDKAG
210 220 230 240 250
RFDQQSMVCG QCHVEYYFDG KNKAVKFPWD EGMKVENMEQ YYDAIAFSDW
260 270 280 290 300
TNSLSKTPML KAQHPEYETW SAGIHGKNNV TCIDCHMPKV QNAEGKLYTD
310 320 330 340 350
HKIGNPFDNF AQTCANCHTQ DKASLQKVVA ERKQAIHDLK IKVEDQLVHA
360 370 380 390 400
HFEAKAAWDA GATDAEMKPI LNDIRHAQWR WDLAIASHGI HMHAPEEGLR
410 420 430 440 450
MLGSAMDKAA DARTKLARLL ATKGITHEIP LPDISTKEKA QKAIGLNMQQ
460 470
INAEKQDFLK TVVPQWEDQA RKNGLLSQ
Length:478
Mass (Da):53,787
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AD7521E66215571
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX70548.1

NCBI Reference Sequences

More...
RefSeqi
WP_000101770.1, NC_010102.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABX70548; ABX70548; SPAB_05272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spq:SPAB_05272

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1016998.12.peg.4938

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX70548.1
RefSeqiWP_000101770.1, NC_010102.1

3D structure databases

ProteinModelPortaliA9N1R7
SMRiA9N1R7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX70548; ABX70548; SPAB_05272
KEGGispq:SPAB_05272
PATRICifig|1016998.12.peg.4938

Phylogenomic databases

HOGENOMiHOG000278511
KOiK03385
OMAiEMVILWA

Enzyme and pathway databases

UniPathwayi
UPA00653

BioCyciSENT1016998:SPAB_RS21465-MONOMER

Family and domain databases

HAMAPiMF_01182 Cytochrom_C552, 1 hit
InterProiView protein in InterPro
IPR003321 Cyt_c552
IPR017570 Cyt_c_NO2Rdtase_formate-dep
IPR011031 Multihaem_cyt
IPR036280 Multihaem_cyt_sf
PANTHERiPTHR30633 PTHR30633, 1 hit
PfamiView protein in Pfam
PF02335 Cytochrom_C552, 1 hit
PIRSFiPIRSF000243 Cyt_c552, 1 hit
SUPFAMiSSF48695 SSF48695, 1 hit
TIGRFAMsiTIGR03152 cyto_c552_HCOOH, 1 hit
PROSITEiView protein in PROSITE
PS51008 MULTIHEME_CYTC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRFA_SALPB
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9N1R7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: December 5, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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