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Protein

Formimidoylglutamase

Gene

hutG

Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.UniRule annotation

Catalytic activityi

N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoylglutamase (hutG)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Manganese 1UniRule annotation1
Metal bindingi155Manganese 1UniRule annotation1
Metal bindingi155Manganese 2UniRule annotation1
Metal bindingi157Manganese 2UniRule annotation1
Metal bindingi159Manganese 1UniRule annotation1
Metal bindingi241Manganese 1UniRule annotation1
Metal bindingi241Manganese 2UniRule annotation1
Metal bindingi243Manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciSENT1016998:SPAB_RS11100-MONOMER
UniPathwayiUPA00379; UER00552

Names & Taxonomyi

Protein namesi
Recommended name:
FormimidoylglutamaseUniRule annotation (EC:3.5.3.8UniRule annotation)
Alternative name(s):
FormiminoglutamaseUniRule annotation
Formiminoglutamate hydrolaseUniRule annotation
Gene namesi
Name:hutGUniRule annotation
Ordered Locus Names:SPAB_02731
OrganismiSalmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Taxonomic identifieri1016998 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000834141 – 313FormimidoylglutamaseAdd BLAST313

Proteomic databases

PRIDEiA9MTJ4

Structurei

3D structure databases

ProteinModelPortaliA9MTJ4
SMRiA9MTJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000237658
KOiK01479
OMAiNFDAHLD

Family and domain databases

HAMAPiMF_00737 Formimidoylglutam, 1 hit
InterProiView protein in InterPro
IPR005923 HutG
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01227 hutG, 1 hit
PROSITEiView protein in PROSITE
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9MTJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQWYPASPA LWQGRDDSIE APDARRLFQT VTRSETFSPE NWQQKIALMG
60 70 80 90 100
FACDEGVKRN AGRPGAAGGP DALRKALANM ASHQGHERLV DLGNWVAPTP
110 120 130 140 150
DLEGAQQVLR DAVSRCLRAG MRTLVLGGGH ETAFGHGAGV LDAFAQESVG
160 170 180 190 200
IINLDAHLDL RQTDRATSGT PFRQLAQLCD AQSRAFHYAC FGVSRAANTQ
210 220 230 240 250
ALWREAQWRN VTVVEDLDCH DALAQMAQFI DKVDKIYLTI DLDVLPVWEM
260 270 280 290 300
PAVSAPAALG VPLIQVLRLI EPVCRSGKLQ AADLVEFNPR FDEDGAAARV
310
AARLGWQIAH WWR
Length:313
Mass (Da):34,371
Last modified:February 5, 2008 - v1
Checksum:i835206DA604469EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000886 Genomic DNA Translation: ABX68109.1
RefSeqiWP_000195696.1, NC_010102.1

Genome annotation databases

EnsemblBacteriaiABX68109; ABX68109; SPAB_02731
KEGGispq:SPAB_02731
PATRICifig|1016998.12.peg.2584

Similar proteinsi

Entry informationi

Entry nameiHUTG_SALPB
AccessioniPrimary (citable) accession number: A9MTJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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