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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Neisseria meningitidis serogroup C (strain 053442)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei607For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

BioCyciNMEN374833:NMCC_RS00160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
Ordered Locus Names:NMCC_0032Imported
OrganismiNeisseria meningitidis serogroup C (strain 053442)Imported
Taxonomic identifieri374833 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000001177 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA9LZT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 220Glutamine amidotransferase type-2InterPro annotationAdd BLAST219
Domaini288 – 428SISInterPro annotationAdd BLAST141
Domaini461 – 602SISInterPro annotationAdd BLAST142

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiTSYYSGC

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A9LZT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGAIRA HHNVVDFLTD GLKRLEYRGY DSSGIAVNTD GKIKRVRRVG
60 70 80 90 100
RVQLMEDAAR EKGISGGIGI GHTRWATHGG VTEPNAHPHI SGGMIAVVHN
110 120 130 140 150
GIIENFESER KRLEGLGYRF ESQTDTEVIA HSINHEYAQN GGRLFEAVQE
160 170 180 190 200
AVKRFHGAYA IAVIAQDKPD ELVVARMGCP LLVALGDDET FIASDVSAVI
210 220 230 240 250
AFTRRVAYLE DGDIALLASD GIKRLTDKNG LPAERKVKVS ELSLASLELG
260 270 280 290 300
PYSHFMQKEI HEQPRAIADT AEVFLDGGFI PENFGKNAQS VFESIRSVKI
310 320 330 340 350
LACGTSYYAA LTAKYWLESI AKIPADVEIA SEYRYRSVIA DPDQLVITIS
360 370 380 390 400
QSGETLDTME ALKYAKSLGH RHSLSICNVM ESALPRESSL VLYTRAGAEI
410 420 430 440 450
GVASTKAFTT QLVALFGLAV TLAKVRGLVS GEDEARYTEE LRQLPGSVQH
460 470 480 490 500
ALNLEPQIAA WAQQFAKKSS ALFLGRGIHY PIALEGALKL KEITYIHAEA
510 520 530 540 550
YPAGELKHGP LALVDENMPV VVIAPNDSLL DKVKANMQEV GARGGELFVF
560 570 580 590 600
ADLDSNFNAT EGVHVIRAPR HVGELSPVVH TIPVQLLAYH TALARGTDVD
610
KPRNLAKSVT VE
Length:612
Mass (Da):66,511
Last modified:February 5, 2008 - v1
Checksum:i9299EBE91C2D65D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA Translation: ABX72262.1
RefSeqiWP_012221107.1, NC_010120.1

Genome annotation databases

EnsemblBacteriaiABX72262; ABX72262; NMCC_0032
KEGGinmn:NMCC_0032

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000381 Genomic DNA Translation: ABX72262.1
RefSeqiWP_012221107.1, NC_010120.1

3D structure databases

ProteinModelPortaliA9LZT0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX72262; ABX72262; NMCC_0032
KEGGinmn:NMCC_0032

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiTSYYSGC

Enzyme and pathway databases

BioCyciNMEN374833:NMCC_RS00160-MONOMER

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA9LZT0_NEIM0
AccessioniPrimary (citable) accession number: A9LZT0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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