UniProtKB - A9LLI7 (RP6L2_ARATH)
Protein
Protein RRP6-like 2
Gene
RRP6L2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed:23555312, PubMed:25211139). Involved in association with RRP6L1 in the silencing of the solo LTR locus. Controls levels of non-coding RNAs (ncRNAs) from the solo LTR locus. Seems to function independently of the RNA-mediated gene silencing (RdDM) pathway (PubMed:23555312). Functions redundantly with RRP6L1 in the regulation of FLC locus. Participates in the maintenance of trimethylated 'Lys-27' (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derived from the FLC locus. Seems not involved in the exosomal RNA degradation (PubMed:25211139). May be involved in poly(A)-mediated RNA degradation (PubMed:18285452).3 Publications
GO - Molecular functioni
- 3'-5'-exoribonuclease activity Source: GO_Central
- nucleotide binding Source: InterPro
- single-stranded RNA binding Source: GO_Central
GO - Biological processi
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- gene silencing by RNA-directed DNA methylation Source: UniProtKB
- histone mRNA catabolic process Source: GO_Central
- nuclear polyadenylation-dependent antisense transcript catabolic process Source: GO_Central
- nuclear polyadenylation-dependent CUT catabolic process Source: GO_Central
- nuclear polyadenylation-dependent rRNA catabolic process Source: GO_Central
- nuclear polyadenylation-dependent snoRNA catabolic process Source: GO_Central
- nuclear polyadenylation-dependent snRNA catabolic process Source: GO_Central
- nuclear polyadenylation-dependent tRNA catabolic process Source: GO_Central
- nuclear retention of unspliced pre-mRNA at the site of transcription Source: GO_Central
- polyadenylation-dependent RNA catabolic process Source: UniProtKB
- polyadenylation-dependent snoRNA 3'-end processing Source: GO_Central
- positive regulation of histone H3-K27 trimethylation Source: UniProtKB
- rRNA processing Source: TAIR
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease |
Biological process | RNA-mediated gene silencing |
Names & Taxonomyi
Protein namesi | Recommended name: Protein RRP6-like 21 PublicationShort name: AtRRP6L21 Publication |
Gene namesi | Name:RRP6L21 Publication Ordered Locus Names:At5g35910Imported ORF Names:MIK22.22Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G35910 |
TAIRi | locus:2165189, AT5G35910 |
Subcellular locationi
Cytosol
- cytosol Source: TAIR
Nucleus
- nuclear exosome (RNase complex) Source: GO_Central
- nucleolus Source: UniProtKB
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000433631 | 1 – 870 | Protein RRP6-like 2Add BLAST | 870 |
Proteomic databases
PaxDbi | A9LLI7 |
PRIDEi | A9LLI7 |
ProteomicsDBi | 227971 |
PTM databases
iPTMneti | A9LLI7 |
Expressioni
Gene expression databases
ExpressionAtlasi | A9LLI7, baseline and differential |
Genevisiblei | A9LLI7, AT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 263 – 428 | 3'-5' exonucleaseSequence analysisAdd BLAST | 166 | |
Domaini | 479 – 559 | HRDCPROSITE-ProRule annotationAdd BLAST | 81 |
Phylogenomic databases
eggNOGi | KOG2206, Eukaryota |
HOGENOMi | CLU_010129_4_1_1 |
InParanoidi | A9LLI7 |
OMAi | DRDFHFY |
OrthoDBi | 677201at2759 |
PhylomeDBi | A9LLI7 |
Family and domain databases
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR010997, HRDC-like_sf IPR002121, HRDC_dom IPR012337, RNaseH-like_sf |
Pfami | View protein in Pfam PF01612, DNA_pol_A_exo1, 1 hit PF00570, HRDC, 1 hit |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00341, HRDC, 1 hit |
SUPFAMi | SSF47819, SSF47819, 1 hit SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50967, HRDC, 1 hit |
i Sequence
Sequence statusi: Complete.
A9LLI7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDGNMDVDE SPVSWKVKSL EKLIDGSSFS STLSRLSSSS RLIPTSRDFH
60 70 80 90 100
FYYNFDEFKR PIDEITGTSQ STLATIGDSE QVWGKSMKFP GDVDDVYAED
110 120 130 140 150
WLCNVNDELI ERFDVSVDEF QRIRKKEKEI GRSVVADDGD DGFQMVYGKK
160 170 180 190 200
KKPVGNVVTG SAAVNGGGSV IDVKMAERDK NSSGKAKVPF HVPTIKKPQE
210 220 230 240 250
EYNILVNNAN LPFEHVWLER SEDDLRAMHP LEKFSVLDFV DKDVNEMEPV
260 270 280 290 300
KPLPLEQTPF KFVQEVKDLK ELVAKLRSVE EFAVDLEHNQ YRSFQGLTCL
310 320 330 340 350
MQISTRTEDY IVDTFKLRIH IGPYLREIFK DPKKKKVMHG ADRDIIWLQR
360 370 380 390 400
DFGIYVCNLF DTGQASRVLN LERNSLEFLL QHFCGVTANK EYQNADWRIR
410 420 430 440 450
PLPEEMTRYA REDTHYLLYI YDLIKLELQR MAKDDAHTDS PLLEVYKRSY
460 470 480 490 500
DVCTQLYEKE LLTENSYLHV YGLQAAGFNA AQLAIVAGLC EWRDFIARAE
510 520 530 540 550
DESTGYVLPN KVLLEIAKEM PDSVGKLRRM LKSKHPYIER NVDSVVSVIR
560 570 580 590 600
QSMQHYAAFE SAALSLKDVS PGNVMDKNIE PISEKKDLHT GDVASPSLKE
610 620 630 640 650
NSSQLESTRD LIMGAANTNE GRGLGSGLFG SAKVSAAVRI SKKPSSGLGA
660 670 680 690 700
LLGNAASKKK SRTDEKVKED VKLEQIRSSV NLSFHSFTEK VPDSKSTSET
710 720 730 740 750
SPKVYGKPEE MSSTMPASVS KEDGVKELKD DSEEASEIVG TSGRVSESKV
760 770 780 790 800
SSSEMGDIIL LENGDEKKVD AEDEPMSLSE LSTNFQKCFK SMNKSKKAQK
810 820 830 840 850
QTEFLNIEPF DYEAARKEVK FGEGHKGRQG KREAAAGQKK GSTQEQSEFG
860 870
QGKRRQAFPA SGNRSMSFKN
Sequence cautioni
The sequence BAB09932 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU240663 mRNA Translation: ABX52080.1 AB005236, AB025602 Genomic DNA Translation: BAB09932.1 Sequence problems. CP002688 Genomic DNA Translation: AED94025.1 |
RefSeqi | NP_198440.2, NM_122982.4 |
Genome annotation databases
EnsemblPlantsi | AT5G35910.1; AT5G35910.1; AT5G35910 |
GeneIDi | 833577 |
Gramenei | AT5G35910.1; AT5G35910.1; AT5G35910 |
KEGGi | ath:AT5G35910 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU240663 mRNA Translation: ABX52080.1 AB005236, AB025602 Genomic DNA Translation: BAB09932.1 Sequence problems. CP002688 Genomic DNA Translation: AED94025.1 |
RefSeqi | NP_198440.2, NM_122982.4 |
3D structure databases
SMRi | A9LLI7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT5G35910.1 |
PTM databases
iPTMneti | A9LLI7 |
Proteomic databases
PaxDbi | A9LLI7 |
PRIDEi | A9LLI7 |
ProteomicsDBi | 227971 |
Genome annotation databases
EnsemblPlantsi | AT5G35910.1; AT5G35910.1; AT5G35910 |
GeneIDi | 833577 |
Gramenei | AT5G35910.1; AT5G35910.1; AT5G35910 |
KEGGi | ath:AT5G35910 |
Organism-specific databases
Araporti | AT5G35910 |
TAIRi | locus:2165189, AT5G35910 |
Phylogenomic databases
eggNOGi | KOG2206, Eukaryota |
HOGENOMi | CLU_010129_4_1_1 |
InParanoidi | A9LLI7 |
OMAi | DRDFHFY |
OrthoDBi | 677201at2759 |
PhylomeDBi | A9LLI7 |
Miscellaneous databases
PROi | PR:A9LLI7 |
Gene expression databases
ExpressionAtlasi | A9LLI7, baseline and differential |
Genevisiblei | A9LLI7, AT |
Family and domain databases
InterProi | View protein in InterPro IPR002562, 3'-5'_exonuclease_dom IPR010997, HRDC-like_sf IPR002121, HRDC_dom IPR012337, RNaseH-like_sf |
Pfami | View protein in Pfam PF01612, DNA_pol_A_exo1, 1 hit PF00570, HRDC, 1 hit |
SMARTi | View protein in SMART SM00474, 35EXOc, 1 hit SM00341, HRDC, 1 hit |
SUPFAMi | SSF47819, SSF47819, 1 hit SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50967, HRDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RP6L2_ARATH | |
Accessioni | A9LLI7Primary (citable) accession number: A9LLI7 Secondary accession number(s): Q9FFL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 16, 2015 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names