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Entry version 57 (11 Dec 2019)
Sequence version 1 (05 Feb 2008)
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Protein

1,3-beta-galactosyl-N-acetylhexosamine phosphorylase Cphy3030

Gene

Cphy_3030

Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversibly phosphorolyzes beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine to form alpha-D-galactopyranose 1-phosphate and acetyl-D-glucosamine. Active towards galacto-N-biose and lacto-N-biose. Does not phosphorolyze galacto-N-tetraose or lacto-N-tetraose. In the reverse reaction has activity toward N-acetyl-D-glucosamine and N-acetyl-D-galactosamine, but not L-rhamnose, D-glucose or D-galactose.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.8 mM for lacto-N-biose1 Publication
  2. KM=10 mM for galacto-N-biose1 Publication
  3. KM=1.9 mM for N-acetyl-D-glucosamine1 Publication
  4. KM=3.3 mM for N-acetyl-D-galactosamine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei316Proton donorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processCarbohydrate metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    CPHY357809:G1GAJ-3147-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.4.1.211 10424

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...
    CAZyi
    GH112 Glycoside Hydrolase Family 112

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    1,3-beta-galactosyl-N-acetylhexosamine phosphorylase Cphy3030 (EC:2.4.1.211)
    Alternative name(s):
    D-galactosyl-1,4-L-rhamnose phosphorylase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Ordered Locus Names:Cphy_3030
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri357809 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000370 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004052901 – 7241,3-beta-galactosyl-N-acetylhexosamine phosphorylase Cphy3030Add BLAST724

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    A9KQ75

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    357809.Cphy_3030

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A9KQ75

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycoside hydrolase 112 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CT8 Bacteria
    ENOG410XP7H LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000015674

    KEGG Orthology (KO)

    More...
    KOi
    K15533

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PMHEYTV

    Database of Orthologous Groups

    More...
    OrthoDBi
    205469at2

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.10, 1 hit
    2.60.40.1180, 1 hit
    3.40.50.880, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029062 Class_I_gatase-like
    IPR013780 Glyco_hydro_b
    IPR013783 Ig-like_fold
    IPR035080 Lact_bio_phlase-like_N
    IPR012711 Lacto-N-biose_phosphorylase
    IPR035356 LBP_C
    IPR035363 LBP_M

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF09508 Lact_bio_phlase, 1 hit
    PF17386 LBP_C, 1 hit
    PF17385 LBP_M, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52317 SSF52317, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02336 TIGR02336, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A9KQ75-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSEKLTGRVT VPTDVDMIQE TKEIAERWGA DALRDCDGTD MPDELKKMPA
    60 70 80 90 100
    KIYSTYYTTR KDNAWANANP DEVQQVYLMT EFYTAMSQGE LRIPLMKHLY
    110 120 130 140 150
    KDQLKPNTIH DIKRWWEVVD RTTGEPLVLD AWEYDENNQE VIILNPDHFH
    160 170 180 190 200
    DYTVSFLAFI IWDPVHMYNF ITNDWQDVEH QITYDVRQPK TQKYVIEKLK
    210 220 230 240 250
    RWMKENPDSD VVRFTTFFHQ FTLVFNEFAK EKFVDWFGYS ASVSPYILEQ
    260 270 280 290 300
    FEKEVGYKFR PEYIIDQGYH NNTNRVPSKE FRDFQEFQQR EVAKLMKVLV
    310 320 330 340 350
    DICHDNDKEA MMFLGDHWIG TEPFGEYFKH VGLDAVVGSV GNGTTLRLIS
    360 370 380 390 400
    DIPGVKYTEG RFLPYFFPDV FHEGGDPIKE AKVNWVTARR AILRKPVDRI
    410 420 430 440 450
    GYGGYLKLAL DFPEFIQYIE EVCDEFRLLY DNMGGQSPYS HFKVGVLNSW
    460 470 480 490 500
    GKIRSWGTHM VAHAIDYKQT YSYAGVLEAL SGMPFDVEFI SFEDVIKNPV
    510 520 530 540 550
    ILNECGVVIN VGDAYTGPSG GAYWTNEKVS SAVKAFVAQG GGFIGVGEPS
    560 570 580 590 600
    ACEHQGRYFT LANVLGVNKE IGFSMSTDKY NWDEHSHFIT EDSNESINFG
    610 620 630 640 650
    EGMKNIYALD GAQILRKDGQ DVQMAVNQFG DGRSVYISGI PYSFENSRML
    660 670 680 690 700
    YRAIFWAAGM EQEMKKWYSS NYNVEVNYYP ATKKYCIVNN TYEPQETMIY
    710 720
    DGLGREYSMK LKANDILWFT FLED
    Length:724
    Mass (Da):83,856
    Last modified:February 5, 2008 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8C569DA5949169B
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP000885 Genomic DNA Translation: ABX43387.1

    NCBI Reference Sequences

    More...
    RefSeqi
    WP_012201038.1, NC_010001.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    ABX43387; ABX43387; Cphy_3030

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cpy:Cphy_3030

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000885 Genomic DNA Translation: ABX43387.1
    RefSeqiWP_012201038.1, NC_010001.1

    3D structure databases

    SMRiA9KQ75
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi357809.Cphy_3030

    Protein family/group databases

    CAZyiGH112 Glycoside Hydrolase Family 112

    Proteomic databases

    PRIDEiA9KQ75

    Genome annotation databases

    EnsemblBacteriaiABX43387; ABX43387; Cphy_3030
    KEGGicpy:Cphy_3030

    Phylogenomic databases

    eggNOGiENOG4105CT8 Bacteria
    ENOG410XP7H LUCA
    HOGENOMiHOG000015674
    KOiK15533
    OMAiPMHEYTV
    OrthoDBi205469at2

    Enzyme and pathway databases

    BioCyciCPHY357809:G1GAJ-3147-MONOMER
    BRENDAi2.4.1.211 10424

    Family and domain databases

    Gene3Di2.60.40.10, 1 hit
    2.60.40.1180, 1 hit
    3.40.50.880, 1 hit
    InterProiView protein in InterPro
    IPR029062 Class_I_gatase-like
    IPR013780 Glyco_hydro_b
    IPR013783 Ig-like_fold
    IPR035080 Lact_bio_phlase-like_N
    IPR012711 Lacto-N-biose_phosphorylase
    IPR035356 LBP_C
    IPR035363 LBP_M
    PfamiView protein in Pfam
    PF09508 Lact_bio_phlase, 1 hit
    PF17386 LBP_C, 1 hit
    PF17385 LBP_M, 1 hit
    SUPFAMiSSF52317 SSF52317, 1 hit
    TIGRFAMsiTIGR02336 TIGR02336, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAHP1_LACP7
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9KQ75
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: February 5, 2008
    Last modified: December 11, 2019
    This is version 57 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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