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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Activity regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei795-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1045-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei194Uracil; via amide nitrogenUniRule annotation1
Binding sitei2005-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPHY357809:G1GAJ-604-MONOMER
UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:Cphy_0557
OrganismiLachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Taxonomic identifieri357809 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
Proteomesi
  • UP000000370 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001391111 – 209Uracil phosphoribosyltransferaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi357809.Cphy_0557

Structurei

3D structure databases

ProteinModelPortaliA9KIB0
SMRiA9KIB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 1395-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni199 – 201Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
HOGENOMiHOG000262754
KOiK00761
OMAiRICGYEI
OrthoDBiPOG091H02GN

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

A9KIB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNVCIMDHP LIQHKIGIMR MKTTSTKEFR DLVAEVAMLI YYEASRNLPL
60 70 80 90 100
ADKEVETPLT KAIVKEIEGK KLCVVPILRA GMHMADGILN LTPNAKVGHI
110 120 130 140 150
GLYRNEETLE PVEYFCKLPS DAPDREIFVV DPMLATGGSA IAAITLLKRR
160 170 180 190 200
GIEKIRFLCL IAAPEGLKKL QEAHPDVDVF IGALDERLNE QGYILPGLGD

AGDRIYGTK
Length:209
Mass (Da):23,125
Last modified:February 5, 2008 - v1
Checksum:i08F64E25FB16A049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000885 Genomic DNA Translation: ABX40944.1
RefSeqiWP_012198588.1, NC_010001.1

Genome annotation databases

EnsemblBacteriaiABX40944; ABX40944; Cphy_0557
KEGGicpy:Cphy_0557

Similar proteinsi

Entry informationi

Entry nameiUPP_LACP7
AccessioniPrimary (citable) accession number: A9KIB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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