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UniProtKB - A9KHK4 (GLRP_LACP7)

Entry version 67 (02 Dec 2020)
Sequence version 1 (05 Feb 2008)
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Protein

D-galactosyl-beta-1->4-L-rhamnose phosphorylase

Gene

Cphy_1920

Organism
Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversibly phosphorolyzes beta-D-galactosyl-(1->4)-L-rhamnose to form alpha-D-galactose 1-phosphate and L-rhamnose. Does not phosphorolyze galacto-N-biose or lacto-N-biose. In the reverse reaction, has the highest activity toward L-rhamnose, also has activity toward L-mannose, and low activity toward L-lyxose, D-glucose, 2-deoxy-D-glucose and D-galactose.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.4 mM for L-rhamnose1 Publication
  2. KM=78 mM for L-mannose1 Publication
  3. KM=7.9 mM for beta-D-galactosyl-(1->4)-L-rhamnose1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei319Proton donorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosyltransferase, Transferase
    Biological processCarbohydrate metabolism, Rhamnose metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		CPHY357809:G1GAJ-1981-MONOMER
    MetaCyc:MONOMER-15015

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.4.1.247, 10424

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...    CAZyi    		GH112, Glycoside Hydrolase Family 112

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    D-galactosyl-beta-1->4-L-rhamnose phosphorylase1 Publication (EC:2.4.1.247)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Ordered Locus Names:Cphy_1920
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) (Clostridium phytofermentans)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri357809 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Firmicutes › Clostridia › Clostridiales › Lachnospiraceae ›
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000370 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004052921 – 722D-galactosyl-beta-1->4-L-rhamnose phosphorylaseAdd BLAST722

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...    STRINGi    		357809.Cphy_1920

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		A9KHK4

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycoside hydrolase 112 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		COG5426, Bacteria

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_022367_0_0_9

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		GIYSTIC

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		2.60.40.10, 1 hit
    3.40.50.880, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR029062, Class_I_gatase-like
    IPR013783, Ig-like_fold
    IPR035080, Lact_bio_phlase-like_N
    IPR012711, Lacto-N-biose_phosphorylase
    IPR035356, LBP_C
    IPR035363, LBP_M

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF09508, Lact_bio_phlase, 1 hit
    PF17386, LBP_C, 1 hit
    PF17385, LBP_M, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF52317, SSF52317, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR02336, TIGR02336, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A9KHK4-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEQQKEITKG GFTLPGEAGF EKLTLELANR WGADVIRDSD GTELSDDILN 
            60         70         80         90        100
    AGYGIYSTIC LIRDHNAWAK ANIDKLQQTF LVTSPVVANS ETLTIDLMEG 
           110        120        130        140        150
    FFKEQFLVND SEEALEYWQV YDRTTETLLQ KESWSYHPQN QTVVLTGICP 
           160        170        180        190        200
    WHKYTVSFMA YRIWEEISMY NHTTNNWNKE HLMQIDPIHK ETQEYLLTWM 
           210        220        230        240        250
    DDWCKKHEQT TVVRFTSMFY NFVWMWGSNE KNRYLFSDWA SYDFTVSPHA 
           260        270        280        290        300
    LKLFEEEYGY VLTAEDFIHQ GKFHVTHMPA DKHKLDWMEF INNFVVDFGK 
           310        320        330        340        350
    KLIDIVHNYG KLAYVFYDDS WVGVEPYHKN FEKFGFDGLI KCVFSGFEVR 
           360        370        380        390        400
    LCAGVKVNTH ELRLHPYLFP VGLGGAPTFM EGGNPTLDAK NYWISVRRAL 
           410        420        430        440        450
    LREPIDRIGL GGYLHLVEDF PDFTDYIEKI ANEFRRIKEL HNAGKPMALK 
           460        470        480        490        500
    PRIAVLHSWG SLRSWTLSGH FHETYMHDLI HINESLSGLP FDVKFINFED 
           510        520        530        540        550
    INQGALEEVD VVINAGIMGS AWTGGQAWED QEIIERLTRF VYEGKAFIGV 
           560        570        580        590        600
    NEPSALTGYD TLYRMAHVLG VDMDLGDRVS HGRYSFTEEP VEELEFAECG 
           610        620        630        640        650
    PKAKRNIYLT DGLAKVLKEE NGIPVMTSYE FGRGRGIYLA SYEHSIKNAR 
           660        670        680        690        700
    TLLNIILYAA GESFHQEGIT NNVYTECAYY EKDKILVMIN NSNTLQESSV 
           710        720 
    TIKGRTYTKD IPAFDTVILP LE
    Length:722
    Mass (Da):83,279
    Last modified:February 5, 2008 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i897574E1F1AE970C
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		CP000885 Genomic DNA Translation: ABX42289.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...    EnsemblBacteriai    		ABX42289; ABX42289; Cphy_1920

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		cpy:Cphy_1920

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		CP000885 Genomic DNA Translation: ABX42289.1

    3D structure databases

    SMRiA9KHK4
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi357809.Cphy_1920

    Protein family/group databases

    CAZyiGH112, Glycoside Hydrolase Family 112

    Genome annotation databases

    EnsemblBacteriaiABX42289; ABX42289; Cphy_1920
    KEGGicpy:Cphy_1920

    Phylogenomic databases

    eggNOGiCOG5426, Bacteria
    HOGENOMiCLU_022367_0_0_9
    OMAiGIYSTIC

    Enzyme and pathway databases

    BioCyciCPHY357809:G1GAJ-1981-MONOMER
    MetaCyc:MONOMER-15015
    BRENDAi2.4.1.247, 10424

    Family and domain databases

    Gene3Di2.60.40.10, 1 hit
    3.40.50.880, 2 hits
    InterProiView protein in InterPro
    IPR029062, Class_I_gatase-like
    IPR013783, Ig-like_fold
    IPR035080, Lact_bio_phlase-like_N
    IPR012711, Lacto-N-biose_phosphorylase
    IPR035356, LBP_C
    IPR035363, LBP_M
    PfamiView protein in Pfam
    PF09508, Lact_bio_phlase, 1 hit
    PF17386, LBP_C, 1 hit
    PF17385, LBP_M, 1 hit
    SUPFAMiSSF52317, SSF52317, 1 hit
    TIGRFAMsiTIGR02336, TIGR02336, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLRP_LACP7
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9KHK4
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: February 5, 2008
    Last modified: December 2, 2020
    This is version 67 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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