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Entry version 91 (16 Jan 2019)
Sequence version 1 (05 Feb 2008)
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Protein
Submitted name:

ATP-binding cassette subfamily C member 3

Gene

abcc3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi669 – 676ATPPROSITE-ProRule annotation8
Nucleotide bindingi1327 – 1334ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-159418 Recycling of bile acids and salts
R-XTR-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette subfamily C member 3Imported
Submitted name:
LOC100135090 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcc3Imported
Synonyms:LOC100135090Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1003737 abcc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 55HelicalSequence analysisAdd BLAST20
Transmembranei75 – 92HelicalSequence analysisAdd BLAST18
Transmembranei104 – 123HelicalSequence analysisAdd BLAST20
Transmembranei135 – 154HelicalSequence analysisAdd BLAST20
Transmembranei174 – 190HelicalSequence analysisAdd BLAST17
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Transmembranei434 – 453HelicalSequence analysisAdd BLAST20
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Transmembranei536 – 564HelicalSequence analysisAdd BLAST29
Transmembranei969 – 996HelicalSequence analysisAdd BLAST28
Transmembranei1016 – 1040HelicalSequence analysisAdd BLAST25
Transmembranei1080 – 1099HelicalSequence analysisAdd BLAST20
Transmembranei1105 – 1129HelicalSequence analysisAdd BLAST25
Transmembranei1205 – 1222HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000012239 Expressed in 12 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000026744

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini320 – 602ABC transmembrane type-1InterPro annotationAdd BLAST283
Domaini635 – 859ABC transporterInterPro annotationAdd BLAST225
Domaini976 – 1256ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini1293 – 1527ABC transporterInterPro annotationAdd BLAST235

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163867

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108314

KEGG Orthology (KO)

More...
KOi
K05667

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFQVEQM

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A9JRK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METFCGSGDL GSQFWDSNLT LYTDNPDVTP CFQNTVLAWI PCVYLWVALP
60 70 80 90 100
FYLLYLKYNR RGYIVLSMLS KAKTVFGVLL WCVCWADLFY SFHGLVQNQS
110 120 130 140 150
PPPVYFVTPL ILGITMITAT VLAQYERLRG VQSSGVLIIF WFLATVCAII
160 170 180 190 200
PFRSKVMASA RQGQVTDKFR FTTFFLYFSL LVIELLLSCF KEARPFFSPV
210 220 230 240 250
RDEINPCPES DAGFLSRLTF WWFTKMAILG YKRPLEDKDL WSLNEDDTSN
260 270 280 290 300
VVVTNLIKEW EKEKSNLAQM QVSYSKKPEA VLNHTDEKAY ESDVLIVDNK
310 320 330 340 350
KPKEPSFLKV LLRTFGPYFL IGSFFKLFQD LLSFVNPQLL SILITFIKNK
360 370 380 390 400
DAPSWWGFCI AVLMFLTSLV QTLILHQHFQ YCFVTGMRLR SAITGIIYRK
410 420 430 440 450
SLVITNSAKR SSTVGEVVNL MSVDAQRFQD LTTFLNMLWS APLQICLALY
460 470 480 490 500
FLWQALGPSV LAGVAVMVLL IPINAFIAMK TRAFQVEQMQ YKDSRIKLMN
510 520 530 540 550
EILNGIKVLK LYAWEPSFAQ KVLEIRNKEL NILKKAAYLN ALSTFAWTSA
560 570 580 590 600
PFLVALTTFA VYVTVDEKNI LDAEKAFVSL SLFNILRFPL NMLPQVISNL
610 620 630 640 650
AQASVSIKRI QNFLANDELD LNAVTKDKTL PGNAITVHNG TFSWAKNGGA
660 670 680 690 700
ILQNINLLVP SGSLVAVVGQ VGCGKSSLVS ALLGEMEKEE GEVSVRGSVA
710 720 730 740 750
YVPQQAWIQN CTLKDNILFG RAANEKNYKK VLEACALVTD LEVLPGGDQT
760 770 780 790 800
EIGEKGINLS GGQKQRVSLA RAVFSNADVY LLDDPLSAVD AHVAKHIFDN
810 820 830 840 850
VIGPDGLLRG KTRVLVTHGI SFLPQVDHIV VLVDGRVTEM GSYQELLKQN
860 870 880 890 900
GAFSEFLRNY AFDDEVEEED ITIPDEEEVL LAEETLSTHT DLADNEPVAN
910 920 930 940 950
EARKKFIRQI SILSDGEPSH AMSTRRRFTE KKPSENLVAK QPPTEKLIQT
960 970 980 990 1000
ETTETGRVKM TVFWQYMKAV GLAISVFICF LYSCQNAAAI GANVWLSDWT
1010 1020 1030 1040 1050
NEPVINQTQQ NTQMRVGVYA ALGILQGLLV MTSSFSLAIA GIGAARKLHS
1060 1070 1080 1090 1100
ALLDNKMHTP QSFYDTTPIG RIINRFSKDI YVIDEVIPGT ILMFLATFFT
1110 1120 1130 1140 1150
SLSTMIVIVA STPLFAVVII PLAIAYIFVQ RFYVATSRQL KRLESVSRSP
1160 1170 1180 1190 1200
IYSHFSETIT GASIIRAYGR QNSFIVLSDN KVDENQKSYY PGIVSNRWLG
1210 1220 1230 1240 1250
VRVEFVGNCV VLFAALFAVL GREHLSPGLV GLSVSYALQV TMSLNWMVRM
1260 1270 1280 1290 1300
TSDLETNIVA VERVKEYAEN ETEAPWHIED TKPPEDWPSK GEVELSNYSV
1310 1320 1330 1340 1350
RYRAGLDLVL KNLNLKVNGG EKVGIVGRTG AGKSSMTLCL FRILEPAEGI
1360 1370 1380 1390 1400
VKIDNVNISE IGLQDLRSRL TIIPQDPVLF SGTLRMNLDP FNKYSDDEIW
1410 1420 1430 1440 1450
KALELSNLKK FVAGQPSQLE YECSEGGENL SVGQRQLVCL ARALLRKTRI
1460 1470 1480 1490 1500
LILDEATAAI DLETDDLIQM TIRTQFEDCT VLTIAHRLNT IMDYTRVLVL
1510 1520 1530
DKGRIAEFDT PTNLIALKGI FYGMAKDAGL A
Length:1,531
Mass (Da):171,325
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9860E68513695A5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01051718 Genomic DNA No translation available.
AAMC01051719 Genomic DNA No translation available.
AAMC01051720 Genomic DNA No translation available.
AAMC01051721 Genomic DNA No translation available.
AAMC01051722 Genomic DNA No translation available.
BC155696 mRNA Translation: AAI55697.1

NCBI Reference Sequences

More...
RefSeqi
NP_001107301.1, NM_001113829.1
XP_012826971.1, XM_012971517.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Str.58494

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000026744; ENSXETP00000026744; ENSXETG00000012239

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100135090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100135090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01051718 Genomic DNA No translation available.
AAMC01051719 Genomic DNA No translation available.
AAMC01051720 Genomic DNA No translation available.
AAMC01051721 Genomic DNA No translation available.
AAMC01051722 Genomic DNA No translation available.
BC155696 mRNA Translation: AAI55697.1
RefSeqiNP_001107301.1, NM_001113829.1
XP_012826971.1, XM_012971517.2
UniGeneiStr.58494

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000026744

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000026744; ENSXETP00000026744; ENSXETG00000012239
GeneIDi100135090
KEGGixtr:100135090

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8714
XenbaseiXB-GENE-1003737 abcc3

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000163867
HOVERGENiHBG108314
KOiK05667
OMAiAFQVEQM
OrthoDBi138195at2759
TreeFamiTF105199

Enzyme and pathway databases

ReactomeiR-XTR-159418 Recycling of bile acids and salts
R-XTR-382556 ABC-family proteins mediated transport

Gene expression databases

BgeeiENSXETG00000012239 Expressed in 12 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA9JRK6_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9JRK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 16, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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