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UniProtKB - A9JRI0 (HEAT6_DANRE)

Entry version 56 (02 Dec 2020)
Sequence version 1 (05 Feb 2008)
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Protein

HEAT repeat-containing protein 6

Gene

heatr6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:heatr6
ORF Names:zgc:172359
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-080204-118, heatr6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371771 – 1201HEAT repeat-containing protein 6Add BLAST1201

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A9JRI0

PeptideAtlas

More...PeptideAtlasi		A9JRI0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000097730

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati182 – 221HEAT 1Add BLAST40
Repeati460 – 498HEAT 2Add BLAST39
Repeati523 – 560HEAT 3Add BLAST38
Repeati566 – 603HEAT 4Add BLAST38

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4535, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A9JRI0

Database of Orthologous Groups

More...OrthoDBi		106835at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A9JRI0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR025283, DUF4042

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13251, DUF4042, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A9JRI0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKVTFLGS NSSFSPDGKT QGFKSASADT SRFVSLSKPQ HELDGSAQAQ 
        60         70         80         90        100
ISRCFNKLRS LSPSDSASLK TELNLLFDEL ISENYSSSNH DNIPPEVVCE 
       110        120        130        140        150
ILVQASRLVP LSQEHLIIKL CQMIHQLLNQ LQIIVDEHTL DVLVSYCSRA 
       160        170        180        190        200
LRTCSSWTHS EVLLALSSLV YGNGSKCQRY LPDLLGPSGV LVKYGDPKQP 
       210        220        230        240        250
DIELRRSAVH CIANLCLSVP SQPYLEEPYK SVCYGILLRT LQSTKPPDVD 
       260        270        280        290        300
DIVFCTLLQS ALKGMQYFLN GGKWKAVPNQ DLGALLAVLK RFMFYGLPGI 
       310        320        330        340        350
SVEMPQVLYP APLPQYETIP AVKPEPAQDT PAQKKTAASQ QKKRKSRGKG 
       360        370        380        390        400
KKGAGEGKQD GEADDVSAAG GGDQSGWSHG SQSSMLTSPS VATPQLYPSW 
       410        420        430        440        450
KKCSSDSEFS DPEGGMQSKL RLYQARVRQS SLQCFLAVVK CVEKRILYGY 
       460        470        480        490        500
WSSFVPDAPG IGGPPPLTLL TIALKDPLPK VRAGSLQVLS ALLEGSRQFL 
       510        520        530        540        550
STAEDTGAPR QAFTPFSATL AASIRELHRG LLLALIAESS CQTLTQVLKC 
       560        570        580        590        600
LAHLVSNVPY NRLRPGLLSP LWKQIRPYVR HRDVNVRVSS LTLFGALVST 
       610        620        630        640        650
QAPLPEVQLL LQQPGSASSL GSGISTPQES PLSWRQPARR DEEASSPAAA 
       660        670        680        690        700
EGPEGPCWLL QLCVSLVTQP REEPYSDSDA GGSNGAPLEP SPVRLEALQV 
       710        720        730        740        750
LAHLVKGYFS LAQASLLELG QLSARCLTEQ DPSVQLHGAK LLEELGTGII 
       760        770        780        790        800
QQYRADANTP QSAKRVPVNQ VVQFWSEVLG GPLISALQNE HHPTLQTSAC 
       810        820        830        840        850
DTLSSILPQA FSQLPDKTQV LCITILLGLT YSENSLVKAA AVRALGVYIL 
       860        870        880        890        900
FPCLREDVMF VADTANAILT ALDDRSPNVR AKAAWSLGNL TDTLIVNMQS 
       910        920        930        940        950
VGLEFQEDFS DMLLLNMLRS ATKASADKDR VKSNAVRALG NLLHFLQPGH 
       960        970        980        990       1000
LGKPVFEQPL LEAMRALIDT VRGDATMKVR WNACYALGNA FRNQHLPLGS 
      1010       1020       1030       1040       1050
AVWSTEAFSA LSCVVTSCKN FKVRIKSAAA LSVPATRECY GDSQQFSEVW 
      1060       1070       1080       1090       1100
RSLAQALEHS EETEDFLEYR YCASLRSQLC RALLHLLSLC QPDDLPALGS 
      1110       1120       1130       1140       1150
SVSGQSRPAL QALLISHLRD EGLVPSAGAD GEEALDHSTP EDGWTLLTDT 
      1160       1170       1180       1190       1200
LTRLKGLLGE PVMDSNEDLE SVLSFLQDVV RNFEEMKEAE SKESSLVLGK 

S
Length:1,201
Mass (Da):130,503
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE157CDBCB8461119
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QS71F1QS71_DANRE
HEAT repeat-containing protein 6
heatr6
1,201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC155667 mRNA Translation: AAI55668.1

NCBI Reference Sequences

More...RefSeqi		NP_001107785.1, NM_001114313.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		567838

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:567838

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC155667 mRNA Translation: AAI55668.1
RefSeqiNP_001107785.1, NM_001114313.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000097730

Proteomic databases

PaxDbiA9JRI0
PeptideAtlasiA9JRI0

Genome annotation databases

GeneIDi567838
KEGGidre:567838

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		63897
ZFINiZDB-GENE-080204-118, heatr6

Phylogenomic databases

eggNOGiKOG4535, Eukaryota
InParanoidiA9JRI0
OrthoDBi106835at2759
PhylomeDBiA9JRI0

Miscellaneous databases

Protein Ontology

More...PROi		PR:A9JRI0

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR025283, DUF4042
PfamiView protein in Pfam
PF13251, DUF4042, 1 hit
SUPFAMiSSF48371, SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEAT6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9JRI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: December 2, 2020
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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