UniProtKB - A9JR78 (TONSL_DANRE)
Protein
Tonsoku-like protein
Gene
tonsl
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks.By similarity
GO - Molecular functioni
- histone binding Source: UniProtKB
GO - Biological processi
- double-strand break repair via homologous recombination Source: UniProtKB
- replication fork processing Source: UniProtKB
Keywordsi
Biological process | DNA damage, DNA repair |
Names & Taxonomyi
Protein namesi | Recommended name: Tonsoku-like proteinAlternative name(s): NF-kappa-B inhibitor-like protein 2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 |
Gene namesi | Name:tonsl Synonyms:nfkbil2 ORF Names:im:7145273, zgc:171416 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-041111-230, tonsl |
Subcellular locationi
Nucleus
- nuclear replication fork Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Tonsl deficiency causes growth deficits, vertebral abnormalities, reduced neutrophil numbers, and death at early stages of larvae development.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326636 | 1 – 1427 | Tonsoku-like proteinAdd BLAST | 1427 |
Proteomic databases
PaxDbi | A9JR78 |
PeptideAtlasi | A9JR78 |
Interactioni
Subunit structurei
Component of the MMS22L-TONSL complex.
By similarityGO - Molecular functioni
- histone binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000096098 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 27 – 60 | TPR 1Add BLAST | 34 | |
Repeati | 67 – 100 | TPR 2Add BLAST | 34 | |
Repeati | 107 – 147 | TPR 3Add BLAST | 41 | |
Repeati | 162 – 195 | TPR 4Add BLAST | 34 | |
Repeati | 202 – 235 | TPR 5Add BLAST | 34 | |
Repeati | 242 – 275 | TPR 6Add BLAST | 34 | |
Repeati | 311 – 344 | TPR 7Add BLAST | 34 | |
Repeati | 352 – 385 | TPR 8Add BLAST | 34 | |
Repeati | 522 – 551 | ANK 1Add BLAST | 30 | |
Repeati | 555 – 584 | ANK 2Add BLAST | 30 | |
Repeati | 591 – 620 | ANK 3Add BLAST | 30 | |
Repeati | 1113 – 1137 | LRR 1Add BLAST | 25 | |
Repeati | 1141 – 1168 | LRR 2Add BLAST | 28 | |
Repeati | 1174 – 1197 | LRR 3Add BLAST | 24 | |
Repeati | 1234 – 1258 | LRR 4Add BLAST | 25 | |
Repeati | 1293 – 1316 | LRR 5Add BLAST | 24 | |
Repeati | 1321 – 1346 | LRR 6Add BLAST | 26 | |
Repeati | 1377 – 1400 | LRR 7Add BLAST | 24 |
Sequence similaritiesi
Belongs to the Tonsoku family.Curated
Keywords - Domaini
ANK repeat, Leucine-rich repeat, Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4308, Eukaryota |
InParanoidi | A9JR78 |
OrthoDBi | 56880at2759 |
PhylomeDBi | A9JR78 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits 1.25.40.20, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF13516, LRR_6, 2 hits PF13176, TPR_7, 2 hits PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00367, LRR_CC, 3 hits SM00028, TPR, 8 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50005, TPR, 7 hits PS50293, TPR_REGION, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
A9JR78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSTKEIKQL QKAKSKAQSS NNLKEEASLC NQLGEVYAKT GDYQAAIEEH
60 70 80 90 100
RQELALSEIL HDVIGSAVAN RKIGECYAEL GNIEAALKHQ RLHLNLARSV
110 120 130 140 150
HDAAEEQRAL ATIGRTYLFL FDSDQSANSL KHAEDAFKRS LAIVDERLEG
160 170 180 190 200
TVSPREISEM KARLLLNLGC VYDGMKEPQR CSDLIRQSIY IAEKNNLLED
210 220 230 240 250
LYRANFNLGS IHFRNGQHSR AMRCFEQSKE CARKMKDKFS ESECFHSIGK
260 270 280 290 300
ILLHLGDFSA ARRSLKKAFC LGSQQPSDRE AVKKDFRHAI RGCQLEQTAA
310 320 330 340 350
EVTQKFSHEA LDLSEQLGDL YCKVGCYSKA LEAYQTQLAC AEALAKPARE
360 370 380 390 400
LAVIHVSLAA TYTDLRQHHR AVEHYRQELQ LRKGNPKEEC ETWLNMAVCQ
410 420 430 440 450
EEMCQSMETL DHCFTSALNC AEKSGLNKLQ RRVLRVWLQA QRRCGSSQCD
460 470 480 490 500
DTEARLMELC ERDGLSLDQS EDEDEEDEVD NSEPLEDSDI QYSESDDEDL
510 520 530 540 550
EGYDKMVTGR RKTQRWNRRN EKGETVLHRA CIEGNLKQVQ YLIEQGHPVN
560 570 580 590 600
VRDYCGWTPL HESCNYGHQE IVAFLLDRGA NVNDPGGREC GGITPLHDTL
610 620 630 640 650
SCGHFSVARL LVLRGASVTV RNSKGHTPLD TLRQWFKTYS GQLDPETKQE
660 670 680 690 700
CLETEKLIKR ALSGDVSVVC AAPRQQKELQ DSQLFDAEYS EPLLRESPPS
710 720 730 740 750
PPPITRPAAT VPTSKDSAPK HRSTSASTRR PRGMEVDVLY GDDSSSSDNP
760 770 780 790 800
DSDCSLSPLR PVRSRPRSPP AQSPQEVPSS QELPSVYGIK ETTVPPQSES
810 820 830 840 850
GRLEYQKAMQ NLGSAKSRLF SQSLSDPAFT STPAVSANSR AALVPEDQYL
860 870 880 890 900
ADDWLEDDLI DMQPKKKRRV SEHNATRETT SRSQNNSSTI AEVPPRVQSC
910 920 930 940 950
SSRGSLSLKK GSNKPRQVKM NQLPGMVMLG RREVSRSQSP IMTQESDHIQ
960 970 980 990 1000
EPAPPSHQAM PPASFQNRAA HVPAPIRMRV KVQDNVFLIP VPHSEADSCT
1010 1020 1030 1040 1050
VAWLCDQAAQ RYYQMCGLLP RLSLQKEGAL LLPTDPLLAV LHTNEEVLAE
1060 1070 1080 1090 1100
VCSWDLPPLP ERYRKACESL GVEENRRVSR VCEVQDSSSC VSVCGLSLSP
1110 1120 1130 1140 1150
ASLNPLLRAL KLQASLTELR ISANRLNDEL LPEMMAAAAT MPRLRVLDIS
1160 1170 1180 1190 1200
ANQITGEGLR KASDAFETRS QAAFPCLEEL NLSMNPLGDG WTQALASLLS
1210 1220 1230 1240 1250
SCPLLSSLSL QACGLSARFL QQHRLLLANA MASTGNMRSV CLSHNALGST
1260 1270 1280 1290 1300
GFELVLKTLP MHCLTHLELS AVCRGPSDQP SMEILTKLLA QGDCPLTHLN
1310 1320 1330 1340 1350
LSGNGLTDHS VLLLARCLPV CPSLVSLDLS ANPLVTSTGL HSLLNGLVEA
1360 1370 1380 1390 1400
RRPLGHLNLQ GCQVSGPLAE DCLDSLSDHI RDLRLCSQSL NKLDQDALQQ
1410 1420
SWKRRTEAVH IFSRNSKCML SISSPSH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1R859 | F1R859_DANRE | NF-kappa-B inhibitor-like protein 2 | tonsl | 1,427 | Annotation score: | ||
A0A2R8Q570 | A0A2R8Q570_DANRE | NF-kappa-B inhibitor-like protein 2 | tonsl | 1,395 | Annotation score: | ||
A0A2R8QLA3 | A0A2R8QLA3_DANRE | NF-kappa-B inhibitor-like protein 2 | tonsl | 1,451 | Annotation score: | ||
A0A2R8QAS4 | A0A2R8QAS4_DANRE | NF-kappa-B inhibitor-like protein 2 | tonsl | 1,427 | Annotation score: |
Sequence cautioni
The sequence AAH92364 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1068 | E → Q in AAH92364 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1305 | G → E in AAH92364 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1348 | V → M in AAH92364 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC092364 mRNA Translation: AAH92364.1 Different initiation. BC155547 mRNA Translation: AAI55548.1 |
RefSeqi | NP_001104618.1, NM_001111148.1 |
Genome annotation databases
GeneIDi | 492655 |
KEGGi | dre:492655 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC092364 mRNA Translation: AAH92364.1 Different initiation. BC155547 mRNA Translation: AAI55548.1 |
RefSeqi | NP_001104618.1, NM_001111148.1 |
3D structure databases
SMRi | A9JR78 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000096098 |
Proteomic databases
PaxDbi | A9JR78 |
PeptideAtlasi | A9JR78 |
Genome annotation databases
GeneIDi | 492655 |
KEGGi | dre:492655 |
Organism-specific databases
CTDi | 4796 |
ZFINi | ZDB-GENE-041111-230, tonsl |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota KOG4308, Eukaryota |
InParanoidi | A9JR78 |
OrthoDBi | 56880at2759 |
PhylomeDBi | A9JR78 |
Miscellaneous databases
PROi | PR:A9JR78 |
Family and domain databases
Gene3Di | 1.25.40.10, 2 hits 1.25.40.20, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF13516, LRR_6, 2 hits PF13176, TPR_7, 2 hits PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00367, LRR_CC, 3 hits SM00028, TPR, 8 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 3 hits PS50005, TPR, 7 hits PS50293, TPR_REGION, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TONSL_DANRE | |
Accessioni | A9JR78Primary (citable) accession number: A9JR78 Secondary accession number(s): Q569P2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families