Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. Succinyl-diaminopimelate desuccinylase (dapE)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00019

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotation
Ordered Locus Names:BT_0075
OrganismiBartonella tribocorum (strain CIP 105476 / IBS 506)
Taxonomic identifieri382640 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000001592 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000837451 – 2862,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseAdd BLAST286

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi382640.Btr_0075

Structurei

3D structure databases

ProteinModelPortaliA9ILJ3
SMRiA9ILJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DMJ Bacteria
COG2171 LUCA
HOGENOMiHOG000027983
KOiK00674
OMAiQVPCALI

Family and domain databases

Gene3Di1.10.166.10, 1 hit
HAMAPiMF_00811 DapD, 1 hit
InterProiView protein in InterPro
IPR005664 DapD_Trfase_Hexpep_rpt_fam
IPR001451 Hexapep
IPR023180 THP_succinylTrfase_dom1
IPR037133 THP_succinylTrfase_N_sf
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF14602 Hexapep_2, 1 hit
PF14805 THDPS_N_2, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR00965 dapD, 1 hit

Sequencei

Sequence statusi: Complete.

A9ILJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHLTQLEII IEKAFDDRDS INTTTKGEIR ESVEHTLSLL DKGEIRVAER
60 70 80 90 100
QKNGQWYVHQ WLKKAVLLSF RLNPMQIITG GINGTHWWDK VPSKFSGWKE
110 120 130 140 150
DDFQKAGFRS VPGAIVRHSA YVAPNVILMP SFINLGAFVD EGTMVDTWTT
160 170 180 190 200
VGSCAQIGKH VHLSGGVGIG GVLEPLQANP TIIEDHCFIG ARSEVVEGCI
210 220 230 240 250
IREGAVLGMG VFIGQSTKII DRTTGEIFIG EVPAYSVVVP GSLPGKPLPN
260 270 280
GEAGPNLYCA VIVKRVDQKT REKTSINELL RDETQC
Length:286
Mass (Da):31,376
Last modified:February 5, 2008 - v1
Checksum:iC6A3360F20E28420
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260525 Genomic DNA Translation: CAK00571.1
RefSeqiWP_012230384.1, NC_010161.1

Genome annotation databases

KEGGibtr:BT_0075

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM260525 Genomic DNA Translation: CAK00571.1
RefSeqiWP_012230384.1, NC_010161.1

3D structure databases

ProteinModelPortaliA9ILJ3
SMRiA9ILJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi382640.Btr_0075

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGibtr:BT_0075

Phylogenomic databases

eggNOGiENOG4105DMJ Bacteria
COG2171 LUCA
HOGENOMiHOG000027983
KOiK00674
OMAiQVPCALI

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00019

Family and domain databases

Gene3Di1.10.166.10, 1 hit
HAMAPiMF_00811 DapD, 1 hit
InterProiView protein in InterPro
IPR005664 DapD_Trfase_Hexpep_rpt_fam
IPR001451 Hexapep
IPR023180 THP_succinylTrfase_dom1
IPR037133 THP_succinylTrfase_N_sf
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF14602 Hexapep_2, 1 hit
PF14805 THDPS_N_2, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR00965 dapD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPD_BART1
AccessioniPrimary (citable) accession number: A9ILJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again