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UniProtKB - A9FZ87 (EREMS_SORC5)
Protein
(+)-eremophilene synthase
Gene
geoA
Organism
Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
Status
Functioni
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene eremophilene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP).
1 PublicationCatalytic activityi
- EC:4.2.3.1641 Publication
Cofactori
Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity
: terpenoid biosynthesis Pathwayi
This protein is involved in the pathway terpenoid biosynthesis, which is part of Secondary metabolite biosynthesis.1 PublicationView all proteins of this organism that are known to be involved in the pathway terpenoid biosynthesis and in Secondary metabolite biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 91 | Magnesium 1By similarity | 1 | |
Metal bindingi | 96 | Magnesium 1By similarity | 1 | |
Metal bindingi | 96 | Magnesium 2By similarity | 1 | |
Binding sitei | 185 | SubstrateBy similarity | 1 | |
Metal bindingi | 231 | Magnesium 3By similarity | 1 | |
Metal bindingi | 235 | Magnesium 3By similarity | 1 | |
Binding sitei | 238 | SubstrateBy similarity | 1 | |
Metal bindingi | 239 | Magnesium 3By similarity | 1 |
GO - Molecular functioni
- lyase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- terpenoid biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 4.2.3.164, 9327 |
UniPathwayi | UPA00213 |
Names & Taxonomyi
Protein namesi | Recommended name: (+)-eremophilene synthase1 Publication (EC:4.2.3.1641 Publication)Alternative name(s): Sesquiterpene cyclase1 Publication Terpene synthase1 Publication Type I terpene cyclase1 Publication |
Gene namesi | Name:geoA1 Publication Ordered Locus Names:sce8552Imported |
Organismi | Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56)) |
Taxonomic identifieri | 448385 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Sorangiineae › Polyangiaceae › Sorangium › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000443303 | 1 – 329 | (+)-eremophilene synthaseAdd BLAST | 329 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 317 – 318 | Substrate bindingBy similarity | 2 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 91 – 95 | DDXXD motif1 Publication | 5 |
Domaini
The Asp-Asp-Xaa-Xaa-Asp (DDXXD) motif is important for the catalytic activity, presumably through binding to Mg2+.1 Publication
Sequence similaritiesi
Belongs to the terpene synthase family.Curated
Phylogenomic databases
eggNOGi | COG0664, Bacteria |
HOGENOMi | CLU_042538_4_2_7 |
OMAi | DLIEYAM |
OrthoDBi | 1869158at2 |
Family and domain databases
Gene3Di | 1.10.600.10, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034686, Terpene_cyclase-like_2 |
SFLDi | SFLDG01020, Terpene_Cyclase_Like_2, 1 hit |
SUPFAMi | SSF48576, SSF48576, 1 hit |
i Sequence
Sequence statusi: Complete.
A9FZ87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDRTSVVV SKRDAGGFEY PFAASCHPGR EVTEQRTLAW VRRLRLVPDG
60 70 80 90 100
RSLSRLKATN FSHLAAWLLP SASTQTLQLA SDFTAVLFLL DDAYDEGQLS
110 120 130 140 150
TDPESVEWLN EKYLGELFGY TEADMSDPLT RGMLDVRERI RRSHPHFFLN
160 170 180 190 200
RWLSHFQYYY EANLWEANNR KQMRVPHLEE YLMMRRYSGA VYTYCDLLEL
210 220 230 240 250
LLERPLPLEV VQHPLIQTVR DICNDILCWT NDYFSLGKEL TNGETHNLIV
260 270 280 290 300
VLRNECVSTL EEAIDRLKDM HDRRVAEYQG VKEKVLALWA DDEIRLYLDA
310 320
VEAMIAGNQR WALEAGRYSG LESLIVRAG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM746676 Genomic DNA Translation: CAN98722.1 |
RefSeqi | WP_012241161.1, NC_010162.1 |
Genome annotation databases
EnsemblBacteriai | CAN98722; CAN98722; sce8552 |
KEGGi | scl:sce8552 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM746676 Genomic DNA Translation: CAN98722.1 |
RefSeqi | WP_012241161.1, NC_010162.1 |
3D structure databases
SMRi | A9FZ87 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 448385.sce8552 |
Genome annotation databases
EnsemblBacteriai | CAN98722; CAN98722; sce8552 |
KEGGi | scl:sce8552 |
Phylogenomic databases
eggNOGi | COG0664, Bacteria |
HOGENOMi | CLU_042538_4_2_7 |
OMAi | DLIEYAM |
OrthoDBi | 1869158at2 |
Enzyme and pathway databases
UniPathwayi | UPA00213 |
BRENDAi | 4.2.3.164, 9327 |
Family and domain databases
Gene3Di | 1.10.600.10, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034686, Terpene_cyclase-like_2 |
SFLDi | SFLDG01020, Terpene_Cyclase_Like_2, 1 hit |
SUPFAMi | SSF48576, SSF48576, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EREMS_SORC5 | |
Accessioni | A9FZ87Primary (citable) accession number: A9FZ87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2018 |
Last sequence update: | February 5, 2008 | |
Last modified: | February 23, 2022 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families