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Entry version 77 (11 Dec 2019)
Sequence version 1 (15 Jan 2008)
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Protein

All-trans-retinyl ester 13-cis isomerohydrolase

Gene

rpe65b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically generates 13-cis retinol, a stereoisomeric form of retinoic acid. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+1 PublicationNote: Binds 1 Fe2+ ion per subunit.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.00044 sec(-1) with all-trans-retinyl ester as substrate.
  1. KM=2.6 µM for all-trans-retinyl ester1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi180Iron; catalyticBy similarity1
    Metal bindingi241Iron; catalyticBy similarity1
    Metal bindingi313Iron; catalyticBy similarity1
    Metal bindingi527Iron; catalyticBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Isomerase
    LigandIron, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-16789

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    5.2.1.7 928

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    All-trans-retinyl ester 13-cis isomerohydrolase (EC:3.1.1.901 Publication)
    Short name:
    13cIMH
    Alternative name(s):
    Lutein isomerase
    Meso-zeaxanthin isomerase (EC:5.3.3.22By similarity)
    Retinal pigment epithelium-specific 65 kDa protein homolog B
    Short name:
    RPE56b
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:rpe65b
    Synonyms:rpepb
    ORF Names:si:ch211-198n5.5
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

    Organism-specific databases

    Zebrafish Information Network genome database

    More...
    ZFINi
    ZDB-GENE-050410-16 rpe65b

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004187311 – 532All-trans-retinyl ester 13-cis isomerohydrolaseAdd BLAST532

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi112S-palmitoyl cysteine; in membrane formBy similarity1
    Lipidationi329S-palmitoyl cysteine; in membrane formBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Palmitoylated.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    A9C3R9

    PeptideAtlas

    More...
    PeptideAtlasi
    A9C3R9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in brain. Expressed at a low level in the eye.1 Publication

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Detectable in migrating neural crest cells during somitogenesis. At early larval stages, expression is visible in the ventricular zone, the upper and lower jaw and the developing pectoral fins. At later larval stages, expression fades out.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSDARG00000094752 Expressed in 18 organ(s), highest expression level in embryo

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    A9C3R9 baseline

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    7955.ENSDARP00000071014

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A9C3R9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the carotenoid oxygenase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1285 Eukaryota
    COG3670 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182913

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000232156

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    A9C3R9

    KEGG Orthology (KO)

    More...
    KOi
    K20991

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GPGLWNL

    Database of Orthologous Groups

    More...
    OrthoDBi
    895046at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314019

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004294 Carotenoid_Oase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10543 PTHR10543, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03055 RPE65, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    A9C3R9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MVSRLEHPAG GYKKVFESCE ELAEPIPAHV SGKIPAWLSG SLLRMGPGLF
    60 70 80 90 100
    EIGDEPFNHL FDGQALIHKF DLKDGRVTYH RKFIRTDAYV RAMTEKRVVI
    110 120 130 140 150
    TELGTAAYPD PCKNIFSRFF TYFQGTEVTD NCSVNIYPIG EDFYACTETN
    160 170 180 190 200
    FITKVNPDTL ETIKKVDLCN YLSVNGLTAH PHIEADGTVY NIGNCFGKNM
    210 220 230 240 250
    SLAYNIVKIP PLQEEKSDPL AMSKVLVQFP SSERFKPSYV HSFGMTENHF
    260 270 280 290 300
    VFVETPVKIN LLKFLTSWSI RGSNYMDCFE SNDRMGTWFH LAAKNPGKYI
    310 320 330 340 350
    DHKFRTSAFN IFHHINCFED QGFIVVDLCT WKGHEFVYNY LYLANLRQNW
    360 370 380 390 400
    EEVKKAALRA PQPEVRRYVL PLDIHREEQG KNLVSLPYTT ATAVMCSDGT
    410 420 430 440 450
    VWLEPEVLFS GPRQAFEFPQ INYSKFNGKD YTFAYGLGLN HFVPDRICKL
    460 470 480 490 500
    NVKSKETWIW QEPDAYPSEP LFVQSPDAED EDDGVLLSIV VKPGVSQRPA
    510 520 530
    FLLILKATDL TEIARAEVDV LIPLTLHGIY KP
    Length:532
    Mass (Da):60,613
    Last modified:January 15, 2008 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5725F6696CA7C51
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2R8RHN4A0A2R8RHN4_DANRE
    All-trans-retinyl ester 13-cis isom...
    rpe65b
    532Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8QAN0A0A2R8QAN0_DANRE
    All-trans-retinyl ester 13-cis isom...
    rpe65b
    567Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19C → R in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti33K → E in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti52I → V in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti58N → Y in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti66 – 67LI → PL in AAV65108 (PubMed:17868371).Curated2
    Sequence conflicti82K → R in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti99V → A in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti106A → T in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti126T → I in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti133S → L in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti156N → D in AAI33986 (Ref. 3) Curated1
    Sequence conflicti163I → V in AAI33986 (Ref. 3) Curated1
    Sequence conflicti273S → L in AAV65108 (PubMed:17868371).Curated1
    Sequence conflicti388Y → H in AAI55754 (Ref. 3) Curated1
    Sequence conflicti424S → G in AAI33986 (Ref. 3) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY646887 mRNA Translation: AAV65108.1
    CR759968 Genomic DNA Translation: CAP19512.1
    BC133985 mRNA Translation: AAI33986.1
    BC155753 mRNA Translation: AAI55754.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001082902.2, NM_001089433.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSDART00000076542; ENSDARP00000071014; ENSDARG00000094752

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    100002865

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    dre:100002865

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY646887 mRNA Translation: AAV65108.1
    CR759968 Genomic DNA Translation: CAP19512.1
    BC133985 mRNA Translation: AAI33986.1
    BC155753 mRNA Translation: AAI55754.1
    RefSeqiNP_001082902.2, NM_001089433.2

    3D structure databases

    SMRiA9C3R9
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000071014

    Proteomic databases

    PaxDbiA9C3R9
    PeptideAtlasiA9C3R9

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    100002865

    Genome annotation databases

    EnsembliENSDART00000076542; ENSDARP00000071014; ENSDARG00000094752
    GeneIDi100002865
    KEGGidre:100002865

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    100002865
    ZFINiZDB-GENE-050410-16 rpe65b

    Phylogenomic databases

    eggNOGiKOG1285 Eukaryota
    COG3670 LUCA
    GeneTreeiENSGT00950000182913
    HOGENOMiHOG000232156
    InParanoidiA9C3R9
    KOiK20991
    OMAiGPGLWNL
    OrthoDBi895046at2759
    TreeFamiTF314019

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16789
    BRENDAi5.2.1.7 928

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:A9C3R9

    Gene expression databases

    BgeeiENSDARG00000094752 Expressed in 18 organ(s), highest expression level in embryo
    ExpressionAtlasiA9C3R9 baseline

    Family and domain databases

    InterProiView protein in InterPro
    IPR004294 Carotenoid_Oase
    PANTHERiPTHR10543 PTHR10543, 1 hit
    PfamiView protein in Pfam
    PF03055 RPE65, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRP65B_DANRE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A9C3R9
    Secondary accession number(s): A4FVJ4, A9JRQ7, Q4L0V3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: January 15, 2008
    Last modified: December 11, 2019
    This is version 77 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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