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Protein

Argininosuccinate lyase

Gene

argH

Organism
Methanococcus maripaludis (strain C6 / ATCC BAA-1332)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMMAR444158:G1GAE-954-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:MmarC6_0936
OrganismiMethanococcus maripaludis (strain C6 / ATCC BAA-1332)
Taxonomic identifieri444158 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000791 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000890921 – 481Argininosuccinate lyaseAdd BLAST481

Interactioni

Protein-protein interaction databases

STRINGi444158.MmarC6_0936

Structurei

3D structure databases

ProteinModelPortaliA9A8S8
SMRiA9A8S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01748 Archaea
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG093Z09KV

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit

Sequencei

Sequence statusi: Complete.

A9A8S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILRRGRLG SNVKEDVMKF TTSLEFDKEI FESDILCDIA HTTMLVEQNV
60 70 80 90 100
ISEENGKKII AELKKIAEQS MESLNLDPSL DDIHMVIESE LIKELGEDVA
110 120 130 140 150
GRMHTGRSRN DEVATDLRLS LRKKVLEIIT HLIAMEKNML RVSREHKETL
160 170 180 190 200
TVGYTHLQQA QPVTFGHHIL SHVSAIERDI SRFFDTYNRI NISPLGCGAM
210 220 230 240 250
ATTGFNLNRK RTQELLGFYD LIENSMDGVS SRDFVVETMA NISMLGTNLS
260 270 280 290 300
KICEELVVFS SAEFNTIEIA NEYTSTSSIM PQKKNPDVAE ITRAKLSTLN
310 320 330 340 350
GELVTVLTIM KALPNTYNRD LQEISPHLWK SVYTLIDSIQ MVDGMISTVK
360 370 380 390 400
VNKERMKENA EKNYSTATEL ADTLVRECGI AFRMAHGIVG ELVKRSIEEK
410 420 430 440 450
VEIKEIILEV LEKNNLSLSQ EKIDTALDPF ENVKLRNVIG GPAPKEVERA
460 470 480
ISSFNEKISS HKEKLDEKIA EIESVKKNLL K
Length:481
Mass (Da):54,314
Last modified:January 15, 2008 - v1
Checksum:iA66BD5B3BFC6E851
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000867 Genomic DNA Translation: ABX01751.1
RefSeqiWP_012193702.1, NC_009975.1

Genome annotation databases

EnsemblBacteriaiABX01751; ABX01751; MmarC6_0936
GeneIDi5738342
KEGGimmx:MmarC6_0936

Similar proteinsi

Entry informationi

Entry nameiARLY_METM6
AccessioniPrimary (citable) accession number: A9A8S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: January 15, 2008
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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