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Protein

Malate dehydrogenase

Gene

mdh

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei31NADBy similarity1
Binding sitei80SubstrateBy similarity1
Binding sitei86SubstrateBy similarity1
Binding sitei93NADBy similarity1
Binding sitei118SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1
Active sitei173Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 11NADBy similarity6
Nucleotide bindingi116 – 118NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:Nmar_0338
OrganismiNitrosopumilus maritimus (strain SCM1)
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000000792 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001261421 – 304Malate dehydrogenaseAdd BLAST304

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_0338

Structurei

3D structure databases

ProteinModelPortaliA9A450
SMRiA9A450
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246 Archaea
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

A9A450-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITIIGSGKV GGDAALFSAL KRLDDQILLL DVAEGLPQGE AMDINHMLSE
60 70 80 90 100
QGIDVEVKGS NNFEDMKGSN IVVVVAGSGR KPGMTRMDLL KINASIVKSV
110 120 130 140 150
VENVKKYADD SMIIPVTNPL DPMAYITYKV SGFDRSRVFG MGGMLDLSRF
160 170 180 190 200
RQFIHEATGH SRDSIRALVI GEHGENMLPL PRFSSVSGIP LPSLLPKEKL
210 220 230 240 250
EELVQNTKQV AAKVIELKGA TVHAPGNAIS AIVEAVVRDR KQVIPVATYL
260 270 280 290 300
DGEYDHSDVT IGVPAVIGKN GVEKIIELDL NDEEKQVFNK AVENVKGALS

GVEI
Length:304
Mass (Da):32,783
Last modified:January 15, 2008 - v1
Checksum:iCCD4FA954CD3A944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA Translation: ABX12234.1

Genome annotation databases

EnsemblBacteriaiABX12234; ABX12234; Nmar_0338
KEGGinmr:Nmar_0338

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA Translation: ABX12234.1

3D structure databases

ProteinModelPortaliA9A450
SMRiA9A450
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi436308.Nmar_0338

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABX12234; ABX12234; Nmar_0338
KEGGinmr:Nmar_0338

Phylogenomic databases

eggNOGiarCOG00246 Archaea
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_NITMS
AccessioniPrimary (citable) accession number: A9A450
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: January 15, 2008
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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