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Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Nitrosopumilus maritimus (strain SCM1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi25ZincUniRule annotation1
Metal bindingi204ZincUniRule annotation1
Metal bindingi229ZincUniRule annotation1
Metal bindingi233ZincUniRule annotation1
Binding sitei264ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
Alternative name(s):
Cysteinyl-tRNA synthetaseUniRule annotation
Short name:
CysRSUniRule annotation
Gene namesi
Name:cysSUniRule annotation
Ordered Locus Names:Nmar_0967Imported
OrganismiNitrosopumilus maritimus (strain SCM1)Imported
Taxonomic identifieri436308 [NCBI]
Taxonomic lineageiArchaeaThaumarchaeotaNitrosopumilalesNitrosopumilaceaeNitrosopumilus
Proteomesi
  • UP000000792 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi436308.Nmar_0967

Structurei

3D structure databases

ProteinModelPortaliA9A2F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini342 – 403DALR_2InterPro annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili403 – 449Sequence analysisAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 37"HIGH" regionUniRule annotationAdd BLAST11
Motifi261 – 265"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG00486 Archaea
COG0215 LUCA
HOGENOMiHOG000245250
KOiK01883
OMAiHECEIAQ

Family and domain databases

CDDicd00672 CysRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00041 Cys_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR015803 Cys-tRNA-ligase
IPR015273 Cys-tRNA-synt_Ia_DALR
IPR024909 Cys-tRNA/MSH_ligase
IPR014729 Rossmann-like_a/b/a_fold
IPR032678 tRNA-synt_1_cat_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR10890 PTHR10890, 1 hit
PfamiView protein in Pfam
PF09190 DALR_2, 1 hit
PF01406 tRNA-synt_1e, 1 hit
PRINTSiPR00983 TRNASYNTHCYS
SMARTiView protein in SMART
SM00840 DALR_2, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
TIGRFAMsiTIGR00435 cysS, 1 hit

Sequencei

Sequence statusi: Complete.

A9A2F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQDTLSNA EQELDTSKKV KIYLCGVTVY DESHIGHART IIVFDVLRRY
60 70 80 90 100
LEDKGIEIEF IQNFTDVDDK IINRAQAENT SAEAISTKYI ENYFKDFDGL
110 120 130 140 150
NVKHATNYPK ATEHIEDIIK FIEKLIEKEI AYVSKNGVYF AVSKFPEYGK
160 170 180 190 200
LSKKKIDELE SGARIEVDEA KNNPLDFAVW KFSDVEPLWD SPWGKGRPGW
210 220 230 240 250
HIECSAMSTK YLGENFDIHG GGRDLIFPHH ENEIAQSESF TGNQFAKIWM
260 270 280 290 300
HVGMVTIDGE KMSKSIGNIK SIKHVLENWG PNIIRLFCLS GHYSKPIDYS
310 320 330 340 350
EELLKENLTK WRQAETCYYE LIHANSENSE KVGSIVEKLG SEFDKALEDD
360 370 380 390 400
VNTHLALSAF FQLVKEANRL AAEEKLGKED AKIIKTEFLR MLKILGLNIP
410 420 430 440 450
EMTEGMKQEI DTMIENREKF RQEKQFQEAD QIRDKLNEMN IELIDHKGKT
460
IWMKKENIKA EK
Length:462
Mass (Da):53,320
Last modified:January 15, 2008 - v1
Checksum:i38E30D6046721D51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000866 Genomic DNA Translation: ABX12863.1

Genome annotation databases

EnsemblBacteriaiABX12863; ABX12863; Nmar_0967
KEGGinmr:Nmar_0967

Similar proteinsi

Entry informationi

Entry nameiA9A2F2_NITMS
AccessioniPrimary (citable) accession number: A9A2F2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: January 31, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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