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UniProtKB - A8ZWA4 (A8ZWA4_DESOH)

Entry version 70 (13 Nov 2019)
Sequence version 1 (15 Jan 2008)
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Protein
Submitted name:

Penicillin-binding protein, 1A family

Gene

Dole_2534

Organism
Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		DOLE96561:G1GAC-2618-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT51 Glycosyltransferase Family 51

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Penicillin-binding protein, 1A familyImported (EC:2.4.1.129Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Dole_2534Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDesulfococcus oleovorans (strain DSM 6200 / Hxd3)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri96561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Deltaproteobacteria › Desulfobacterales › Desulfobacteraceae › Desulfococcus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008561 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 37HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		96561.Dole_2534

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini360 – 458S1 motifInterPro annotationAdd BLAST99

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4108JQC Bacteria
COG5009 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000041137

KEGG Orthology (KO)

More...KOi		K05366

Identification of Orthologs from Complete Genome Data

More...OMAi		LAQMAMI

Database of Orthologous Groups

More...OrthoDBi		652304at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3810.10, 1 hit
3.40.710.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR012340 NA-bd_OB-fold
IPR036950 PBP_transglycosylase
IPR031376 PCB_OB
IPR001460 PCN-bd_Tpept
IPR003029 S1_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17092 PCB_OB, 1 hit
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249 SSF50249, 1 hit
SSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50126 S1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8ZWA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGGKMANIL KKAIKALALL MVIGMVIAVV AGGVFYYQIS RDLPRIFTID 
        60         70         80         90        100
DYRPPTVTTL YSAEKQKIAE FYTERRIVVP LDRMPPMLIN AFVAAEDARF 
       110        120        130        140        150
FQHTGVDLTG VARAFMKNLE AGAIVQGGST ITQQVAKSFF LSSERTYTRK 
       160        170        180        190        200
IREAILSYRI EKRFSKADIL YLYLNQIYLG HGAYGVAAAA ENYFGKPVEE 
       210        220        230        240        250
LSLAECTLIA GLPQAPSRYS PYRYPARAKN RQLYVLNQMV TGGYISEAEA 
       260        270        280        290        300
QAAREAELEI QPVRSLFQEN APWYAEHVRR YVEAKYGRDT LYNQGLSVYT 
       310        320        330        340        350
AVDLSMQEAA RREVDRGLRD LDKRQGYRGP IRRISEEEIE PFLSSLREEA 
       360        370        380        390        400
LGKMELAVVG DIVQGVVVDV DDEKESAWVR LAHGAGEIPL EEMKWARRPD 
       410        420        430        440        450
PGVAWYQSAA TIKKPSQALK TGDVIWVRIV SLAESPENMA PAAEDRALGT 
       460        470        480        490        500
AVLRLSLEQE PAVEAALICM EARPGLVRAM IGGRDAAKSQ FNRAVQAIRQ 
       510        520        530        540        550
PGSAFKPIIY AAALDKGYTP ASVIIDSAIV FEDTARNFTW KPQNYEERFF 
       560        570        580        590        600
GPTLFRRALE KSHNIPTIKI LMDIGVDYIH DYAKKLGITS PLSRDLSIAL 
       610        620        630        640        650
GSSGLAPVEL AKAYAVFANM GDRVEPVFIT RIEDREGRVL EENRAEPVHV 
       660        670        680        690        700
IGSDTAYIMT HLLEGVVEHG TGRRARELNR PAAGKTGTTD NLNDAWFVGY 
       710        720        730        740        750
TPDFVTVVWV GFDEEQSLGK GETGASAASP IWLGFMQTIL AGKPVKEFEV 
       760        770        780        790        800
PEGVVFSRID AETGLLATDD SRETFFECFK KGTEPTEYAE PADTVDEEGF 

FKGM
Length:804
Mass (Da):89,223
Last modified:January 15, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E8954CFBDECC90F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000859 Genomic DNA Translation: ABW68338.1

NCBI Reference Sequences

More...RefSeqi		WP_012175950.1, NC_009943.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		ABW68338; ABW68338; Dole_2534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dol:Dole_2534

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000859 Genomic DNA Translation: ABW68338.1
RefSeqiWP_012175950.1, NC_009943.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi96561.Dole_2534

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Genome annotation databases

EnsemblBacteriaiABW68338; ABW68338; Dole_2534
KEGGidol:Dole_2534

Phylogenomic databases

eggNOGiENOG4108JQC Bacteria
COG5009 LUCA
HOGENOMiHOG000041137
KOiK05366
OMAiLAQMAMI
OrthoDBi652304at2

Enzyme and pathway databases

BioCyciDOLE96561:G1GAC-2618-MONOMER

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
3.40.710.10, 2 hits
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR012340 NA-bd_OB-fold
IPR036950 PBP_transglycosylase
IPR031376 PCB_OB
IPR001460 PCN-bd_Tpept
IPR003029 S1_domain
PfamiView protein in Pfam
PF17092 PCB_OB, 1 hit
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS50126 S1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8ZWA4_DESOH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8ZWA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 13, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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