UniProtKB - A8Z4X9 (KDPB_STAAT)
Protein
Potassium-transporting ATPase ATP-binding subunit
Gene
kdpB
Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Status
Functioni
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system.UniRule annotation
Catalytic activityi
- EC:7.2.2.6UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 304 | 4-aspartylphosphate intermediateUniRule annotation | 1 | |
Binding sitei | 341 | ATPUniRule annotation | 1 | |
Binding sitei | 345 | ATPUniRule annotation | 1 | |
Binding sitei | 390 | ATPUniRule annotation | 1 | |
Metal bindingi | 513 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 517 | MagnesiumUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 372 – 379 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
- potassium transmembrane transporter activity, phosphorylative mechanism Source: UniProtKB-UniRule
Keywordsi
Molecular function | Translocase |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium-transporting ATPase ATP-binding subunitUniRule annotation (EC:7.2.2.6UniRule annotation)Alternative name(s): ATP phosphohydrolase [potassium-transporting] B chainUniRule annotation Potassium-binding and translocating subunit BUniRule annotation Potassium-translocating ATPase B chainUniRule annotation |
Gene namesi | Name:kdpBUniRule annotation Ordered Locus Names:USA300HOU_2071 |
Organismi | Staphylococcus aureus (strain USA300 / TCH1516) |
Taxonomic identifieri | 451516 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Subcellular locationi
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 54 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 65 – 85 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 216 – 236 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 245 – 265 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 569 – 591 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 611 – 631 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 644 – 664 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of plasma membrane Source: UniProtKB-UniRule
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000078865 | 1 – 675 | Potassium-transporting ATPase ATP-binding subunitAdd BLAST | 675 |
Keywords - PTMi
PhosphoproteinInteractioni
Subunit structurei
The system is composed of three essential subunits: KdpA, KdpB and KdpC.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_025728_2_0_9 |
OMAi | ILWLWFT |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
HAMAPi | MF_00285, KdpB, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006391, P-type_ATPase_bsu_IA IPR001757, P_typ_ATPase |
PANTHERi | PTHR43743, PTHR43743, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 2 hits TIGR01497, kdpB, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
A8Z4X9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHHVNKYFNQ TMVIEALKMS FYKLNLKQLI KNPIMFVVEV GMILTLILIC
60 70 80 90 100
FPDIFGTSYL SRGYLITIFI ILLITILFAN FSEAFAEGRG KAQADSLRQA
110 120 130 140 150
QSNLTARLIE ENGAYRIVNA TELKAGQNIR VENGETIPAD GVVINGLATV
160 170 180 190 200
DESAITGESA PVIKESGGDF DGVIGGTLVT SDWLEIRVES EAGTSFLDKM
210 220 230 240 250
IALVEGAERN KTPNEIALFT LLTTLTIIFL VVIVTLYPIA SYLHLILPIA
260 270 280 290 300
MLIALTVCLI PTTIGGLLSA IGIAGMDRVT QFNVLAKSGR AVEVCGDVDV
310 320 330 340 350
MILDKTGTIT YGNRIASEFL PVNQQMLEKL IVAAYMSSIY DDTPEGKSIV
360 370 380 390 400
RLAKQMYINE LPKDIDGTYK PFTAETRMSG IITNEISVFK GAPNSMINLV
410 420 430 440 450
KQQQGNIPLN IESLCMDVSS KGGTPLIVIE NNVMLGVIYL KDVIKDGLVE
460 470 480 490 500
RFTELRKMGI ETVMCTGDNA LTAATIAKEA GVDRFVAECK PEDKIKVIKD
510 520 530 540 550
EQAKGHIVAM TGDGTNDAPA LAQANIGLAM NSGTISAKEA ANLIDLDSNP
560 570 580 590 600
TKLIEVVKIG KQLLMTRGAL TTFSLANDVA KYFAILPALM MSTIPEMTSL
610 620 630 640 650
NIMHLSSPKS AIISALIFNA LIIVALIPIA MKGVKVKGYS IDRIFINNML
660 670
IYGLGGLIVP FLGIKLIDMI VQFFV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000730 Genomic DNA Translation: ABX30068.1 |
RefSeqi | WP_000546584.1, NC_010079.1 |
Genome annotation databases
EnsemblBacteriai | ABX30068; ABX30068; USA300HOU_2071 |
KEGGi | sax:USA300HOU_2071 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000730 Genomic DNA Translation: ABX30068.1 |
RefSeqi | WP_000546584.1, NC_010079.1 |
3D structure databases
SMRi | A8Z4X9 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ABX30068; ABX30068; USA300HOU_2071 |
KEGGi | sax:USA300HOU_2071 |
Phylogenomic databases
HOGENOMi | CLU_025728_2_0_9 |
OMAi | ILWLWFT |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
HAMAPi | MF_00285, KdpB, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006391, P-type_ATPase_bsu_IA IPR001757, P_typ_ATPase |
PANTHERi | PTHR43743, PTHR43743, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 2 hits TIGR01497, kdpB, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KDPB_STAAT | |
Accessioni | A8Z4X9Primary (citable) accession number: A8Z4X9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | February 10, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |