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Protein

Glutamine synthetase

Gene

PIG59

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetaseUniRule annotation (EC:6.3.1.2UniRule annotation)
Gene namesi
Name:PIG59Imported
Synonyms:GLULImported
ORF Names:hCG_24393Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000135821.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28743

PTM / Processingi

Proteomic databases

PRIDEiA8YXX4

Expressioni

Gene expression databases

BgeeiENSG00000135821
ExpressionAtlasiA8YXX4 baseline and differential

Interactioni

Subunit structurei

Homooctamer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiA8YXX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 359Gln-synt_CInterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the glutamine synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0683 Eukaryota
COG0174 LUCA
HOVERGENiHBG005847
KOiK01915
OMAiMMPDGVT
OrthoDBiEOG091G07E9

Family and domain databases

Gene3Di3.10.20.70, 1 hit
InterProiView protein in InterPro
IPR008147 Gln_synt_b-grasp
IPR036651 Gln_synt_N
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR008146 Gln_synth_cat_dom
IPR027303 Gln_synth_gly_rich_site
IPR027302 Gln_synth_N_conserv_site
PfamiView protein in Pfam
PF00120 Gln-synt_C, 1 hit
PF03951 Gln-synt_N, 1 hit
SMARTiView protein in SMART
SM01230 Gln-synt_C, 1 hit
SUPFAMiSSF54368 SSF54368, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00180 GLNA_1, 1 hit
PS00181 GLNA_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

A8YXX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE
60 70 80 90 100
PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE
110 120 130 140 150
VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP
160 170 180 190 200
SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA
210 220 230 240 250
QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA
260 270 280 290 300
GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL
310 320 330 340 350
TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS
360 370
VTEALIRTCL LNETGDEPFQ YKN
Length:373
Mass (Da):42,064
Last modified:January 15, 2008 - v1
Checksum:i45390C100924FAF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY947343 mRNA Translation: AAY57874.1
AK122784 mRNA Translation: BAG53728.1
CH471067 Genomic DNA Translation: EAW91116.1
CH471067 Genomic DNA Translation: EAW91117.1
CH471067 Genomic DNA Translation: EAW91119.1
CH471067 Genomic DNA Translation: EAW91120.1
CH471067 Genomic DNA Translation: EAW91122.1
RefSeqiNP_001028216.1, NM_001033044.3
NP_001028228.1, NM_001033056.3
NP_002056.2, NM_002065.6
XP_006711341.1, XM_006711278.1
UniGeneiHs.132016
Hs.518525

Genome annotation databases

GeneIDi2752
KEGGihsa:2752

Similar proteinsi

Entry informationi

Entry nameiA8YXX4_HUMAN
AccessioniPrimary (citable) accession number: A8YXX4
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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