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UniProtKB - A8YXX4 (A8YXX4_HUMAN)
Protein
Glutamine synthetase
Gene
PIG59
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:6.3.1.2UniRule annotation
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]ARBA annotationEC:2.3.1.225ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- dynein light chain binding Source: Ensembl
- glutamate-ammonia ligase activity Source: UniProtKB-EC
- glutamate binding Source: Ensembl
- identical protein binding Source: Ensembl
- magnesium ion binding Source: Ensembl
- manganese ion binding Source: Ensembl
- protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- ammonia assimilation cycle Source: Ensembl
- angiogenesis Source: UniProtKB-KW
- cellular response to starvation Source: Ensembl
- glutamine biosynthetic process Source: Ensembl
- positive regulation of epithelial cell proliferation Source: Ensembl
- positive regulation of insulin secretion Source: Ensembl
- positive regulation of synaptic transmission, glutamatergic Source: Ensembl
- regulation of endothelial cell migration Source: Ensembl
- regulation of sprouting angiogenesis Source: Ensembl
- response to glucose Source: Ensembl
Keywordsi
Molecular function | LigaseUniRule annotationImported |
Biological process | AngiogenesisARBA annotation |
Ligand | ATP-bindingUniRule annotation, MagnesiumARBA annotation, ManganeseARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PIG59Imported Synonyms:GLULImported ORF Names:hCG_24393Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000135821 |
Subcellular locationi
Mitochondrion
- Mitochondrion ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Lipid-anchor ARBA annotation
Endoplasmic reticulum
- Microsome ARBA annotation
Other locations
- Membrane ARBA annotation; Lipid-anchor ARBA annotation
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
Mitochondrion
- mitochondrion Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- axon terminus Source: Ensembl
- glial cell projection Source: Ensembl
- myelin sheath Source: Ensembl
- perikaryon Source: Ensembl
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Endoplasmic reticulum, MicrosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000135821, Expressed in medial globus pallidus and 256 other tissues |
Interactioni
GO - Molecular functioni
- dynein light chain binding Source: Ensembl
- identical protein binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 110 – 359 | Gln-synt_CInterPro annotationAdd BLAST | 250 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_036762_1_1_1 |
OMAi | DRRPNAN |
OrthoDBi | 784869at2759 |
Family and domain databases
Gene3Di | 3.10.20.70, 1 hit |
InterProi | View protein in InterPro IPR008147, Gln_synt_b-grasp IPR036651, Gln_synt_N IPR014746, Gln_synth/guanido_kin_cat_dom IPR008146, Gln_synth_cat_dom IPR027303, Gln_synth_gly_rich_site IPR027302, Gln_synth_N_conserv_site |
Pfami | View protein in Pfam PF00120, Gln-synt_C, 1 hit PF03951, Gln-synt_N, 1 hit |
SMARTi | View protein in SMART SM01230, Gln-synt_C, 1 hit |
SUPFAMi | SSF54368, SSF54368, 1 hit SSF55931, SSF55931, 1 hit |
PROSITEi | View protein in PROSITE PS00180, GLNA_1, 1 hit PS00181, GLNA_ATP, 1 hit |
i Sequence
Sequence statusi: Complete.
A8YXX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE
60 70 80 90 100
PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE
110 120 130 140 150
VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP
160 170 180 190 200
SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA
210 220 230 240 250
QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA
260 270 280 290 300
GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL
310 320 330 340 350
TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS
360 370
VTEALIRTCL LNETGDEPFQ YKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY947343 mRNA Translation: AAY57874.1 AK122784 mRNA Translation: BAG53728.1 CH471067 Genomic DNA Translation: EAW91116.1 CH471067 Genomic DNA Translation: EAW91117.1 CH471067 Genomic DNA Translation: EAW91119.1 CH471067 Genomic DNA Translation: EAW91120.1 CH471067 Genomic DNA Translation: EAW91122.1 |
RefSeqi | NP_001028216.1, NM_001033044.3 NP_001028228.1, NM_001033056.3 NP_002056.2, NM_002065.6 XP_006711341.1, XM_006711278.1 |
Genome annotation databases
GeneIDi | 2752 |
KEGGi | hsa:2752 |
MANE-Selecti | ENST00000331872.11; ENSP00000356537.6; NM_001033044.4; NP_001028216.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY947343 mRNA Translation: AAY57874.1 AK122784 mRNA Translation: BAG53728.1 CH471067 Genomic DNA Translation: EAW91116.1 CH471067 Genomic DNA Translation: EAW91117.1 CH471067 Genomic DNA Translation: EAW91119.1 CH471067 Genomic DNA Translation: EAW91120.1 CH471067 Genomic DNA Translation: EAW91122.1 |
RefSeqi | NP_001028216.1, NM_001033044.3 NP_001028228.1, NM_001033056.3 NP_002056.2, NM_002065.6 XP_006711341.1, XM_006711278.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 1536, 661 antibodies from 41 providers |
DNASUi | 2752 |
Genome annotation databases
GeneIDi | 2752 |
KEGGi | hsa:2752 |
MANE-Selecti | ENST00000331872.11; ENSP00000356537.6; NM_001033044.4; NP_001028216.1 |
Organism-specific databases
CTDi | 2752 |
PharmGKBi | PA28743 |
VEuPathDBi | HostDB:ENSG00000135821 |
Phylogenomic databases
HOGENOMi | CLU_036762_1_1_1 |
OMAi | DRRPNAN |
OrthoDBi | 784869at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2752, 30 hits in 1046 CRISPR screens |
ChiTaRSi | GLUL, human |
GenomeRNAii | 2752 |
Gene expression databases
Bgeei | ENSG00000135821, Expressed in medial globus pallidus and 256 other tissues |
Family and domain databases
Gene3Di | 3.10.20.70, 1 hit |
InterProi | View protein in InterPro IPR008147, Gln_synt_b-grasp IPR036651, Gln_synt_N IPR014746, Gln_synth/guanido_kin_cat_dom IPR008146, Gln_synth_cat_dom IPR027303, Gln_synth_gly_rich_site IPR027302, Gln_synth_N_conserv_site |
Pfami | View protein in Pfam PF00120, Gln-synt_C, 1 hit PF03951, Gln-synt_N, 1 hit |
SMARTi | View protein in SMART SM01230, Gln-synt_C, 1 hit |
SUPFAMi | SSF54368, SSF54368, 1 hit SSF55931, SSF55931, 1 hit |
PROSITEi | View protein in PROSITE PS00180, GLNA_1, 1 hit PS00181, GLNA_ATP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8YXX4_HUMAN | |
Accessioni | A8YXX4Primary (citable) accession number: A8YXX4 Secondary accession number(s): A0A024R956 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | January 19, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |