PIG59

Functionⁱ

Catalytic activityⁱ

ATP + L-glutamate + NH₃ = ADP + phosphate + L-glutamine.UniRule annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
dynein light chain binding Source: Ensembl
glutamate-ammonia ligase activity Source: UniProtKB-EC
glutamate binding Source: Ensembl
magnesium ion binding Source: Ensembl
manganese ion binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ammonia assimilation cycle Source: Ensembl
cellular response to starvation Source: Ensembl
glutamine biosynthetic process Source: Ensembl
positive regulation of epithelial cell proliferation Source: Ensembl
positive regulation of insulin secretion Source: Ensembl
positive regulation of synaptic transmission, glutamatergic Source: Ensembl
protein homooligomerization Source: Ensembl
response to glucose Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	LigaseUniRule annotationImported
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamine synthetaseUniRule annotation (EC:6.3.1.2UniRule annotation)
Gene namesⁱ	Name:PIG59Imported Synonyms:GLULImported ORF Names:hCG_24393Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135821.16

EuPathDBⁱ

HostDB:ENSG00000135821.16

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA28743

PharmGKBⁱ

PA28743

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	A8YXX4

PRIDEⁱ

A8YXX4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135821
ExpressionAtlasⁱ	A8YXX4 baseline and differential

Interactionⁱ

Subunit structureⁱ

Homooctamer.SAAS annotation

GO - Molecular functionⁱ

dynein light chain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A8YXX4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	110 – 359	Gln-synt_CInterPro annotationAdd BLAST		250

Sequence similaritiesⁱ

Belongs to the glutamine synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0683 Eukaryota COG0174 LUCA
HOVERGENⁱ	HBG005847
KEGG Orthology (KO) More...KOⁱ	K01915
OMAⁱ	MMPDGVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07E9

Family and domain databases

Gene3Dⁱ	3.10.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR008147 Gln_synt_b-grasp IPR036651 Gln_synt_N IPR014746 Gln_synth/guanido_kin_cat_dom IPR008146 Gln_synth_cat_dom IPR027303 Gln_synth_gly_rich_site IPR027302 Gln_synth_N_conserv_site
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00120 Gln-synt_C, 1 hit PF03951 Gln-synt_N, 1 hit
SMARTⁱ	View protein in SMART SM01230 Gln-synt_C, 1 hit
SUPFAMⁱ	SSF54368 SSF54368, 1 hit SSF55931 SSF55931, 1 hit
PROSITEⁱ	View protein in PROSITE PS00180 GLNA_1, 1 hit PS00181 GLNA_ATP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A8YXX4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE 
        60         70         80         90        100
PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE 
       110        120        130        140        150
VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP 
       160        170        180        190        200
SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA 
       210        220        230        240        250
QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA 
       260        270        280        290        300
GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL 
       310        320        330        340        350
TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS 
       360        370 
VTEALIRTCL LNETGDEPFQ YKN

Length:373

Mass (Da):42,064

Last modified:January 15, 2008 - v1

Checksum:ⁱ45390C100924FAF3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY947343 mRNA Translation: AAY57874.1 AK122784 mRNA Translation: BAG53728.1 CH471067 Genomic DNA Translation: EAW91116.1 CH471067 Genomic DNA Translation: EAW91117.1 CH471067 Genomic DNA Translation: EAW91119.1 CH471067 Genomic DNA Translation: EAW91120.1 CH471067 Genomic DNA Translation: EAW91122.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001028216.1, NM_001033044.3 NP_001028228.1, NM_001033056.3 NP_002056.2, NM_002065.6 XP_006711341.1, XM_006711278.1
UniGeneⁱ	Hs.132016 Hs.518525

Genome annotation databases

GeneIDⁱ	2752
KEGGⁱ	hsa:2752

Protein	Similar proteins		Species	Score	Length
A8YXX4	Glutamine synthetase	)	HUMAN		373
Glutamine synthetase		PANTR		373
Glutamine synthetase		MACMU		373
Glutamine synthetase		MACNE		373
Glutamine synthetase		PONAB		373
+8

Protein	Similar proteins		Species	Score	Length
A8YXX4	Glutamine synthetase	)	HUMAN		373
Glutamine synthetase		PANTR		373
Glutamine synthetase		MACMU		373
Glutamine synthetase		MACNE		373
Glutamine synthetase		PONAB		373
+15

Protein	Similar proteins		Species	Score	Length
A8YXX4	Glutamine synthetase	)	HUMAN		373
Glutamine synthetase		PANTR		373
Glutamine synthetase		MACMU		373
Glutamine synthetase		MACNE		373
Glutamine synthetase		PONAB		373
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY947343 mRNA Translation: AAY57874.1 AK122784 mRNA Translation: BAG53728.1 CH471067 Genomic DNA Translation: EAW91116.1 CH471067 Genomic DNA Translation: EAW91117.1 CH471067 Genomic DNA Translation: EAW91119.1 CH471067 Genomic DNA Translation: EAW91120.1 CH471067 Genomic DNA Translation: EAW91122.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001028216.1, NM_001033044.3 NP_001028228.1, NM_001033056.3 NP_002056.2, NM_002065.6 XP_006711341.1, XM_006711278.1
UniGeneⁱ	Hs.132016 Hs.518525

3D structure databases

SMRⁱ	A8YXX4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	A8YXX4

PRIDEⁱ

A8YXX4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2752
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	2752
KEGGⁱ	hsa:2752

Organism-specific databases

CTDⁱ	2752
EuPathDBⁱ	HostDB:ENSG00000135821.16
PharmGKBⁱ	PA28743

Phylogenomic databases

eggNOGⁱ	KOG0683 Eukaryota COG0174 LUCA
HOVERGENⁱ	HBG005847
KEGG Orthology (KO) More...KOⁱ	K01915
OMAⁱ	MMPDGVT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07E9

Miscellaneous databases

ChiTaRSⁱ	GLUL human
GenomeRNAiⁱ	2752

Gene expression databases

Bgeeⁱ	ENSG00000135821
ExpressionAtlasⁱ	A8YXX4 baseline and differential

Family and domain databases

Gene3Dⁱ	3.10.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR008147 Gln_synt_b-grasp IPR036651 Gln_synt_N IPR014746 Gln_synth/guanido_kin_cat_dom IPR008146 Gln_synth_cat_dom IPR027303 Gln_synth_gly_rich_site IPR027302 Gln_synth_N_conserv_site
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00120 Gln-synt_C, 1 hit PF03951 Gln-synt_N, 1 hit
SMARTⁱ	View protein in SMART SM01230 Gln-synt_C, 1 hit
SUPFAMⁱ	SSF54368 SSF54368, 1 hit SSF55931 SSF55931, 1 hit
PROSITEⁱ	View protein in PROSITE PS00180 GLNA_1, 1 hit PS00181 GLNA_ATP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A8YXX4_HUMAN
Accessionⁱ	A8YXX4Primary (citable) accession number: A8YXX4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 15, 2008
	Last sequence update:	January 15, 2008
	Last modified:	June 20, 2018
	This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A8YXX4 (A8YXX4_HUMAN)

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Glutamine synthetase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Endoplasmic reticulum

Mitochondrion

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ