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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Lactobacillus helveticus (strain DPC 4571)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:lhv_0720
OrganismiLactobacillus helveticus (strain DPC 4571)
Taxonomic identifieri405566 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000790 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000734801 – 799Protein translocase subunit SecAAdd BLAST799

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi405566.lhv_0720

Structurei

3D structure databases

ProteinModelPortaliA8YUC4
SMRiA8YUC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
HOGENOMiHOG000218169
KOiK03070
OMAiFEYDEVM

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

A8YUC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNILKKLYN DDKRELKKFE KYANKVEGYA DEMSKLTDEQ LQAKTPEFRE
60 70 80 90 100
RIKKGESLDD LLPEAFAVAR EGAKRVLGLY PFHVQILGGI ALHFGNIAEM
110 120 130 140 150
MTGEGKTLTA TMPVYLNALE GKGVHVVTVN EYLSSRDEEE MGQLYKWLGL
160 170 180 190 200
TVGLNLNSMS PDEKREAYNC DVTYSTNSEL GFDYLRDNMV VYKEQMVQRP
210 220 230 240 250
LNYAIIDEVD SILIDEARTP LIISGEAEQA NSDYIRADRF VKNLSEDKSD
260 270 280 290 300
DDVDDDEDYG DYKIDWPTKT ISLTRTGIEK ACKHFGLRNL YDVENQKLVH
310 320 330 340 350
HIDQALRANY IMLKDIDYVV QDGEVLIVDS FTGRVMEGRR YSDGLHQAIE
360 370 380 390 400
AKEGVKIQEE SKTQATITYQ NFFRMYKKLS GMTGTAKTEE EEFREIYNMQ
410 420 430 440 450
VITIPTNRPI ARKDMPDILY PTLDSKFHAV VEEIKKRHAN GQPVLVGTVA
460 470 480 490 500
IESSERLSHL LDEAGIPHAV LNAKNHAKEA QIIMNAGQRG AVTIATNMAG
510 520 530 540 550
RGTDIKLGPG VKELGGLAVI GTERHESRRI DNQLRGRSGR QGDPGYTRFY
560 570 580 590 600
LSLEDDLMKR FGGDRVKDFL DRLSDNDDDK VIESRLITRQ VESAQKRVEG
610 620 630 640 650
NNYDIRKQTL QYDDVMRIQR EIIYGERMQV IDADKSLKNV LIPMIHRTID
660 670 680 690 700
SQVDMFTQGD RSEWRLDSLR DFISSSLTSE QVTDSIDFKT ISVEDLKKKL
710 720 730 740 750
YDIVEKNFED KEKALGDPSQ MLEFEKVVIL RVVDDRWTDH IDAMDQLRQS
760 770 780 790
IGLRGYGQLN PLVEYQDSGY RMFEEMISNI EFDVTRLFMK AEIRQNISR
Length:799
Mass (Da):91,576
Last modified:January 15, 2008 - v1
Checksum:i5C2FB12DC21F061E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000517 Genomic DNA Translation: ABX26862.1
RefSeqiWP_012211612.1, NC_010080.1

Genome annotation databases

EnsemblBacteriaiABX26862; ABX26862; lhv_0720
KEGGilhe:lhv_0720

Similar proteinsi

Entry informationi

Entry nameiSECA_LACH4
AccessioniPrimary (citable) accession number: A8YUC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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