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UniProtKB - A8Y7P2 (VKTB2_DABSI)
Protein
Kunitz-type serine protease inhibitor B2
Gene
N/A
Organism
Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis)
Status
Functioni
Serine protease inhibitor that inhibits trypsin.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 41 – 42 | Reactive bond for trypsinBy similarity | 2 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Protein family/group databases
MEROPSi | I02.062 |
Names & Taxonomyi
Protein namesi | Recommended name: Kunitz-type serine protease inhibitor B2Alternative name(s): BPTI-2 Trypsin inhibitor 2 Trypsin inhibitor B2 |
Organismi | Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis) |
Taxonomic identifieri | 343250 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Viperinae › Daboia |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | By similarityAdd BLAST | 24 | |
ChainiPRO_5000284435 | 25 – 84 | Kunitz-type serine protease inhibitor B2Add BLAST | 60 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 81 | PROSITE-ProRule annotation | ||
Disulfide bondi | 40 ↔ 64 | PROSITE-ProRule annotation | ||
Disulfide bondi | 56 ↔ 77 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 81 | BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the venom Kunitz-type family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00109, KU, 1 hit |
Gene3Di | 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR020901, Prtase_inh_Kunz-CS |
Pfami | View protein in Pfam PF00014, Kunitz_BPTI, 1 hit |
PRINTSi | PR00759, BASICPTASE |
SMARTi | View protein in SMART SM00131, KU, 1 hit |
SUPFAMi | SSF57362, SSF57362, 1 hit |
PROSITEi | View protein in PROSITE PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A8Y7P2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGGLLLLL GLLTLWAELT PISGHDRPTF CNLAPESGRC RGHLRRIYYN
60 70 80
LESNKCNVFF YGGCGGNDNN FETRDECRQT CGGK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM411369 mRNA Translation: CAL69610.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM411369 mRNA Translation: CAL69610.1 |
3D structure databases
SMRi | A8Y7P2 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | I02.062 |
Family and domain databases
CDDi | cd00109, KU, 1 hit |
Gene3Di | 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR020901, Prtase_inh_Kunz-CS |
Pfami | View protein in Pfam PF00014, Kunitz_BPTI, 1 hit |
PRINTSi | PR00759, BASICPTASE |
SMARTi | View protein in SMART SM00131, KU, 1 hit |
SUPFAMi | SSF57362, SSF57362, 1 hit |
PROSITEi | View protein in PROSITE PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VKTB2_DABSI | |
Accessioni | A8Y7P2Primary (citable) accession number: A8Y7P2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | January 15, 2008 | |
Last modified: | April 7, 2021 | |
This is version 41 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |