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Protein

SEC14-like protein 1

Gene

Sec14l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 1Curated
Gene namesi
Name:Sec14l1Imported
Synonyms:Kiaa4251Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1921386 Sec14l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004355281 – 715SEC14-like protein 1Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234PhosphothreonineBy similarity1
Modified residuei586PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA8Y5H7
PaxDbiA8Y5H7
PRIDEiA8Y5H7

PTM databases

iPTMnetiA8Y5H7
PhosphoSitePlusiA8Y5H7

Expressioni

Gene expression databases

BgeeiENSMUSG00000020823 Expressed in 291 organ(s), highest expression level in submandibular gland
GenevisibleiA8Y5H7 MM

Interactioni

Subunit structurei

Interacts with DDX58 (via tandem CARD domain); the interaction is direct. Interacts (via GOLD domain) with SLC18A3; the interaction is direct. Interacts with SLC5A7 (via GOLD domain); the interaction is direct.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021177

Structurei

3D structure databases

ProteinModelPortaliA8Y5H7
SMRiA8Y5H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 175PRELI/MSF1PROSITE-ProRule annotationAdd BLAST173
Domaini319 – 495CRAL-TRIOPROSITE-ProRule annotationAdd BLAST177
Domaini521 – 674GOLDPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 510Required for interaction and inhibitory function toward DDX58By similarityAdd BLAST510

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000231147
HOVERGENiHBG060237
OMAiDTWNPPQ
OrthoDBiEOG091G0V9N
TreeFamiTF313988

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR006797 PRELI/MSF1_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
PF04707 PRELI, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit
PS50904 PRELI_MSF1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A8Y5H7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQKYQSPVR VYKHPFELIM AAYERRFPTC PLIPMFVDSD TVSEFKSEDG
60 70 80 90 100
ALHVIERRCK LDIDAPRLLK KIAGVDYVYF VQKNSLNSRD RTLHIEAHNE
110 120 130 140 150
TFSNRVIIHE HCCYTVHPEN EDWTCFEQSA SLDIKSFFGF ESTVEKIAMK
160 170 180 190 200
HYTSNIKKGK EIIEYYLRQL EEEGITFVPR WTPPPVGPSE TCSSSKNQVT
210 220 230 240 250
SAAVLVPDAA AVMEGLSGEN LSSPGTASEP VVGTPDDKLD ADYIKRYLGD
260 270 280 290 300
LTPLQESCLI RLRQWLQETH KGKIPKDEHI LRFLRARDFN IDKAREIMCQ
310 320 330 340 350
SLTWRKQHQV DYILDTWTPP QVLLDYYAGG WHHHDKDGRP LYVLRLGQMD
360 370 380 390 400
TKGLVRALGE EALLRYVLSI NEEGLRRCEE NTKVFGRPIS SWTCLVDLEG
410 420 430 440 450
LNMRHLWRPG VKALLRIIEV VEANYPETLG RLLILRAPRV FPVLWTLVSP
460 470 480 490 500
FIDDNTRRKF LIYAGNDYQG PGGLLDYIDK EIIPDFLSGE CMCDVPEGGL
510 520 530 540 550
VPKSLYRTAE ELENEDLKLW TETIYQSASV FKGAPHEILI QIVDASSVIT
560 570 580 590 600
WDFDVCKGDI VFNIYHSKRS PQPPKKDSLG AHSITSPGGN NVQLIDKVWQ
610 620 630 640 650
LGRDYSMVES PLICKEGESV QGSHVTRWPG FYILQWKFHT MPACAATNLP
660 670 680 690 700
RVDDVLASLQ VSSHKCKVMY YTEVIGSEDF RGSMTSLESS HSGFSQLSAA
710
TTSSSQSQSS SMISR
Length:715
Mass (Da):81,216
Last modified:January 15, 2008 - v1
Checksum:i4495D06ABFE8E4AF
GO
Isoform 2 (identifier: A8Y5H7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     715-715: R → SE

Note: No experimental confirmation available.
Show »
Length:716
Mass (Da):81,276
Checksum:i8CA525D06ABFE8E4
GO
Isoform 3 (identifier: A8Y5H7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     715-715: R → RWRFC

Note: No experimental confirmation available.
Show »
Length:719
Mass (Da):81,808
Checksum:i92A6D034C495D06A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288D → G in BAB23589 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058109715R → SE in isoform 2. 1
Alternative sequenceiVSP_058110715R → RWRFC in isoform 3. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004818 mRNA Translation: BAB23589.1
AL627205 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34612.1
BC005766 mRNA Translation: AAH05766.1
AK172947 mRNA Translation: BAD32225.1
CCDSiCCDS25683.1 [A8Y5H7-3]
CCDS48988.1 [A8Y5H7-2]
CCDS48989.1 [A8Y5H7-1]
RefSeqiNP_001159978.1, NM_001166506.1 [A8Y5H7-1]
NP_001159979.1, NM_001166507.1 [A8Y5H7-2]
NP_083053.2, NM_028777.3 [A8Y5H7-3]
UniGeneiMm.272312

Genome annotation databases

EnsembliENSMUST00000021177; ENSMUSP00000021177; ENSMUSG00000020823 [A8Y5H7-3]
ENSMUST00000090433; ENSMUSP00000087916; ENSMUSG00000020823 [A8Y5H7-1]
ENSMUST00000103026; ENSMUSP00000099315; ENSMUSG00000020823 [A8Y5H7-2]
GeneIDi74136
KEGGimmu:74136
UCSCiuc007mna.2 mouse [A8Y5H7-1]
uc007mnb.2 mouse
uc011yih.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004818 mRNA Translation: BAB23589.1
AL627205 Genomic DNA No translation available.
CH466558 Genomic DNA Translation: EDL34612.1
BC005766 mRNA Translation: AAH05766.1
AK172947 mRNA Translation: BAD32225.1
CCDSiCCDS25683.1 [A8Y5H7-3]
CCDS48988.1 [A8Y5H7-2]
CCDS48989.1 [A8Y5H7-1]
RefSeqiNP_001159978.1, NM_001166506.1 [A8Y5H7-1]
NP_001159979.1, NM_001166507.1 [A8Y5H7-2]
NP_083053.2, NM_028777.3 [A8Y5H7-3]
UniGeneiMm.272312

3D structure databases

ProteinModelPortaliA8Y5H7
SMRiA8Y5H7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021177

PTM databases

iPTMnetiA8Y5H7
PhosphoSitePlusiA8Y5H7

Proteomic databases

MaxQBiA8Y5H7
PaxDbiA8Y5H7
PRIDEiA8Y5H7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021177; ENSMUSP00000021177; ENSMUSG00000020823 [A8Y5H7-3]
ENSMUST00000090433; ENSMUSP00000087916; ENSMUSG00000020823 [A8Y5H7-1]
ENSMUST00000103026; ENSMUSP00000099315; ENSMUSG00000020823 [A8Y5H7-2]
GeneIDi74136
KEGGimmu:74136
UCSCiuc007mna.2 mouse [A8Y5H7-1]
uc007mnb.2 mouse
uc011yih.1 mouse

Organism-specific databases

CTDi6397
MGIiMGI:1921386 Sec14l1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000231147
HOVERGENiHBG060237
OMAiDTWNPPQ
OrthoDBiEOG091G0V9N
TreeFamiTF313988

Miscellaneous databases

ChiTaRSiSec14l1 mouse
PROiPR:A8Y5H7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020823 Expressed in 291 organ(s), highest expression level in submandibular gland
GenevisibleiA8Y5H7 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
IPR006797 PRELI/MSF1_dom
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF03765 CRAL_TRIO_N, 1 hit
PF04707 PRELI, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit
PS50904 PRELI_MSF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS14L1_MOUSE
AccessioniPrimary (citable) accession number: A8Y5H7
Secondary accession number(s): A2A9B9
, Q6A071, Q99J07, Q9DBQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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