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Entry version 107 (29 Sep 2021)
Sequence version 1 (05 Feb 2008)
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Protein

Zinc finger FYVE domain-containing protein

Gene

Zfyve9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri671 – 730FYVE-typePROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger FYVE domain-containing proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfyve9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2652838, Zfyve9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000034557

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation, EndosomeUniRule annotation, MembraneUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A8Y5G5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A8Y5G5

PRoteomics IDEntifications database

More...
PRIDEi
A8Y5G5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
345351

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034557, Expressed in ear and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8Y5G5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8Y5G5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini671 – 730FYVE-typeInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni232 – 307DisorderedSequence analysisAdd BLAST76
Regioni320 – 374DisorderedSequence analysisAdd BLAST55
Regioni568 – 589DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi232 – 275Polar residuesSequence analysisAdd BLAST44
Compositional biasi286 – 307Polar residuesSequence analysisAdd BLAST22
Compositional biasi572 – 588Polar residuesSequence analysisAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri671 – 730FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154290

Database of Orthologous Groups

More...
OrthoDBi
278124at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022557, DUF3480
IPR035438, SARA/endofin
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11979, DUF3480, 1 hit
PF01363, FYVE, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037289, SARA/endofin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00064, FYVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A8Y5G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENYFQAEAY NLDKVLDEFE QNEDETVSPT LLDTKWNKIL DPSSHPLSFN
60 70 80 90 100
PALASVNEPT VSETGPQLKV FSLAGSAPLT KEDKDPCANG QDCSLNPETD
110 120 130 140 150
TMWIDENAVT EDQLIKRNYN QDDQFSAVEV GEEKCGSLTC LPDEKNVLVV
160 170 180 190 200
AVMHNCDKRT LQSDLQDCNN YNSQSLMNSF SCSLDNETRQ TDQFSFSMNG
210 220 230 240 250
STEKGINSEK QMDALNKPKP ERDSVNHLCA ASSNSATSIS SPSQLKDGEN
260 270 280 290 300
VGRDPSTSTV TSLAVNSSQG MDGGPAIKQQ GNYMPDEDLS GMNSSSRTDL
310 320 330 340 350
GISNSFSHSS GELLIKTEPA EERTAEDSLP SDLSLNLKPD TPALSGRDNC
360 370 380 390 400
EQSSDCLGSS ETRADEDEGN DSQMTNWKLT KLNEMSDSQV NEENQMALQS
410 420 430 440 450
NQPEDTNSGG ECVGMADSDL DFKGTCMNES EGYDFSTVND APAANSLSNS
460 470 480 490 500
CDSYGMQSPI VSFVPKTLPS KEDSVTEEKE IEESKSECYS NIYEQRGNEN
510 520 530 540 550
AEGSGLLLNS TGNVMKKNYL HNFCSQIPSV LGQSSPKIAN LQSISVPFGG
560 570 580 590 600
ARPKQPSNLK LQIPKPLSDH LQNDLPANNG NNSKNKNDVL GKAKLGENSA
610 620 630 640 650
VNACSATLGN ISVTDTNGEH LETYEAEISS RPCLALAPDS PDNDLRASQF
660 670 680 690 700
GISARKPFTT LGEVAPVWVP DSQAPNCMKC EARFTFTKRR HHCRACGKVF
710 720 730 740 750
CASCCSLKCK LLYMDRKEAR VCVICHSVLM NVPQPREQRR VWFADGILPN
760 770 780 790 800
GEVADAAKLT MNGTSSAGTL AVSHDPVKPV ATSPLPTEAD TSLFSGSITQ
810 820 830 840 850
VGSPVGSAMN LIPEDGLPPI LISTGVKGDY AVEEKPSQIS VMQQLEDGGP
860 870 880 890 900
DPLVFVLNAN LLSMVKIVNY VNRKCWCFTT KGMHAVGQSE IVILLQCLPD
910 920 930 940 950
EKCLPKDIFN HFVQLYRDAL AGNVVGSLGH SFFSQSFLGS KEHGGFLYVT
960 970 980 990 1000
STYQSLQDLV LPTPPYLFGI LIQKWETPWA KVFPIRLLLR LGAEYRLYPC
1010 1020 1030 1040 1050
PLFSVRFRKP LFGETGHTIM NLLADFRNYQ YTLPVVQGLV VDMEVRKTSI
1060 1070 1080 1090 1100
KIPSNRYNEM MKAMNKSNEH VLAGGACFNE KADSHLVCVQ NDDGNYQTQA
1110 1120 1130 1140 1150
ISIHNQPRKV TGASFFVFSG ALKSSSGYLA KSSIVEDGVM VQITAENMDS
1160 1170 1180 1190 1200
LRQALREMKD FTITCGKADA EDPQEQIHIQ WVDDDKTVNK GVVSPIDGKS
1210 1220 1230 1240 1250
MESITNVKIF HGSEYKANGK VIRWTEVFFL ENDDHHNCLS DPADHSRLTE
1260 1270 1280 1290 1300
HVAKAFCLAL CPHLKLLKED GMTKLGLRVT LDSDQVGYQA GSNGQPLPSQ
1310 1320 1330
YMNDLDSALV PVIHGGACQL SEGPVVMELI FYILENIA
Length:1,338
Mass (Da):146,332
Last modified:February 5, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DD8A777916B6A00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A8R0A2A8R0_MOUSE
Zinc finger FYVE domain-containing ...
Zfyve9
1,397Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0S860A0S860_MOUSE
Zinc finger FYVE domain-containing ...
Zfyve9
706Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_006503052.1, XM_006502989.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106658; ENSMUSP00000102269; ENSMUSG00000034557

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
230597

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_006503052.1, XM_006502989.3

3D structure databases

SMRiA8Y5G5
ModBaseiSearch...

Proteomic databases

EPDiA8Y5G5
MaxQBiA8Y5G5
PRIDEiA8Y5G5
ProteomicsDBi345351

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32995, 115 antibodies

Genome annotation databases

EnsembliENSMUST00000106658; ENSMUSP00000102269; ENSMUSG00000034557
GeneIDi230597

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9372
MGIiMGI:2652838, Zfyve9
VEuPathDBiHostDB:ENSMUSG00000034557

Phylogenomic databases

GeneTreeiENSGT00940000154290
OrthoDBi278124at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
230597, 0 hits in 48 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfyve9, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034557, Expressed in ear and 250 other tissues
ExpressionAtlasiA8Y5G5, baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR022557, DUF3480
IPR035438, SARA/endofin
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF11979, DUF3480, 1 hit
PF01363, FYVE, 1 hit
PIRSFiPIRSF037289, SARA/endofin, 3 hits
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50178, ZF_FYVE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8Y5G5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8Y5G5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 29, 2021
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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