UniProtKB - A8XU52 (PRY1_CAEBR)
Protein
Axin-like protein pry-1
Gene
pry-1
Organism
Caenorhabditis briggsae
Status
Functioni
Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity (By similarity).By similarity
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- negative regulation of canonical Wnt signaling pathway Source: InterPro
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Axin-like protein pry-1By similarityAlternative name(s): Protein polyrayBy similarity |
Gene namesi | Name:pry-1 ORF Names:CBG18802 |
Organismi | Caenorhabditis briggsae |
Taxonomic identifieri | 6238 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | CBG18802 ; CBP41347 ; WBGene00038147 ; Cbr-pry-1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity
Other locations
- cell cortex By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000347253 | 1 – 625 | Axin-like protein pry-1Add BLAST | 625 |
Interactioni
Subunit structurei
Interacts (via N-terminus) with apr-1 (via C-terminus).
Interacts with bar-1 (via ARM repeats), gsk-3, and mig-5 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 6238.CBG18802 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 135 | RGSPROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 544 – 625 | DIXPROSITE-ProRule annotationAdd BLAST | 82 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 443 – 508 | Ser-richAdd BLAST | 66 |
Phylogenomic databases
eggNOGi | ENOG502S33C, Eukaryota |
HOGENOMi | CLU_471192_0_0_1 |
InParanoidi | A8XU52 |
OMAi | CNATTSH |
OrthoDBi | 732602at2759 |
Family and domain databases
Gene3Di | 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR043581, Axin-like IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 1 hit |
Pfami | View protein in Pfam PF00778, DIX, 1 hit PF00615, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
i Sequence
Sequence statusi: Complete.
A8XU52-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESGPSSHLD WARSLEAVLS DRTALDLFQK WLMEYSLPQY LDLYFAIRAF
60 70 80 90 100
ERMTLEGKPE KNQLSKSIYC KFLSSRTGNC EAIPKHFKAP IGEKIRHGID
110 120 130 140 150
LEDRAFSHCS SFVVDFLRRQ HEEFVRSDEF IEALNKVRLR PLFPKPTVIL
160 170 180 190 200
QMSSSTDSSS SHQNTIRKSG SSKRTATQLT AEALLKTKHD RHTKFGELKL
210 220 230 240 250
EKMYPSARQP YVCNATTSHN DSAVSSSFSG DAPGAHRSNR LRHLREEQAH
260 270 280 290 300
QNRDTATVPR VEKQQASSAA DQPFDHATEN GRRGFSMEIT KKLLRHLDKV
310 320 330 340 350
KMNEEMERRI DDIEECRYTT IDMVNGTEAD VDMGGIDEDE ELDDYLKMKM
360 370 380 390 400
TDDSQKGSQN RSPKGPNSGE KEKDGVSKNA TFSPAPPPPR DSPRGLISSH
410 420 430 440 450
LHHHSIHHNT IRPPRRTSKE YPLDISLSRN QYPRHHQIDT NRSLMSQSMC
460 470 480 490 500
VPGPSYSSAS STFSRDSFAP SPMLKGFAGA PGSSKSSQMY DSSGIGSMAP
510 520 530 540 550
SAFSATSSLD YKEKRHRKSL PNHHSMMSNS LTTPRKHHKI GKSLSNLITL
560 570 580 590 600
SYVGSDKIPV VTHVPYDGPM TLAEFKRHFA LPTGGQQLFF KTDCEDGSAP
610 620
FQLLLVRDEH TLLPVFEGRI AAEIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE601380 Genomic DNA Translation: CAP36177.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE601380 Genomic DNA Translation: CAP36177.2 |
3D structure databases
SMRi | A8XU52 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 6238.CBG18802 |
Organism-specific databases
WormBasei | CBG18802 ; CBP41347 ; WBGene00038147 ; Cbr-pry-1 |
Phylogenomic databases
eggNOGi | ENOG502S33C, Eukaryota |
HOGENOMi | CLU_471192_0_0_1 |
InParanoidi | A8XU52 |
OMAi | CNATTSH |
OrthoDBi | 732602at2759 |
Family and domain databases
Gene3Di | 3.10.20.380, 1 hit |
InterProi | View protein in InterPro IPR043581, Axin-like IPR001158, DIX IPR038207, DIX_dom_sf IPR016137, RGS IPR036305, RGS_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR46102, PTHR46102, 1 hit |
Pfami | View protein in Pfam PF00778, DIX, 1 hit PF00615, RGS, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50841, DIX, 1 hit PS50132, RGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRY1_CAEBR | |
Accessioni | A8XU52Primary (citable) accession number: A8XU52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | September 22, 2009 | |
Last modified: | October 7, 2020 | |
This is version 58 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |