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Protein

S-adenosylmethionine synthase

Gene

sams-1

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • K+UniRule annotationNote: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.UniRule annotation
  • Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.UniRule annotation

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (CBG19844), S-adenosylmethionine synthase (sams-1), S-adenosylmethionine synthase (CBG19843)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PotassiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Gene namesi
Name:sams-1Imported
Synonyms:Cbr-sams-1Imported
ORF Names:CBG15526Imported, CBG_15526Imported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componenti: Chromosome X

Organism-specific databases

WormBaseiCBG15526 ; CBP03760 ; WBGene00035751 ; Cbr-sams-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG15526

Structurei

3D structure databases

ProteinModelPortaliA8XM58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 102S-AdoMet_synt_NInterPro annotationAdd BLAST98
Domaini117 – 237S-AdoMet_synt_MInterPro annotationAdd BLAST121
Domaini239 – 376S-AdoMet_synt_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the AdoMet synthase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1506 Eukaryota
COG0192 LUCA
HOGENOMiHOG000245710
InParanoidiA8XM58
KOiK00789
OMAiPWEVPKN
OrthoDBiEOG091G08Z2

Family and domain databases

HAMAPiMF_00086 S_AdoMet_synth1, 1 hit
InterProiView protein in InterPro
IPR022631 ADOMET_SYNTHASE_CS
IPR022630 S-AdoMet_synt_C
IPR022629 S-AdoMet_synt_central
IPR022628 S-AdoMet_synt_N
IPR002133 S-AdoMet_synthetase
IPR022636 S-AdoMet_synthetase_sfam
PANTHERiPTHR11964 PTHR11964, 1 hit
PfamiView protein in Pfam
PF02773 S-AdoMet_synt_C, 1 hit
PF02772 S-AdoMet_synt_M, 1 hit
PF00438 S-AdoMet_synt_N, 1 hit
PIRSFiPIRSF000497 MAT, 1 hit
SUPFAMiSSF55973 SSF55973, 3 hits
TIGRFAMsiTIGR01034 metK, 1 hit
PROSITEiView protein in PROSITE
PS00376 ADOMET_SYNTHASE_1, 1 hit
PS00377 ADOMET_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8XM58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPATFLFTSE SVSTGHPDKM CDQISDAVLD AHLAQDPNAK VACETTTKTG
60 70 80 90 100
MVLLCGEITS KAVVDYQKVV RDCVKKIGFT SSDLGFDSAT CNVVVALESQ
110 120 130 140 150
SPEIAAGVHQ DKGDDEVGAG DQGIMFGYAT DETKETMPLT LLLSHKINAE
160 170 180 190 200
LHRQRRSKEL PWVRPDSKSQ VTIEYESRNG ATIPLRVHTV VVSTQHDPNI
210 220 230 240 250
TLETLRQEIK EKVIKAVIPA NLLDENTVYH INPCGTFVMG GPMGDAGLTG
260 270 280 290 300
RKIIVDTYGG WGAHGGGAFS GKDPTKVDRS AAYAARWVAT SLVNAGLAKR
310 320 330 340 350
VLVQLSYAIG IAKPISVLVY AFGTSPLTDE ELHEIVEDSF DLTPGAIIRE
360 370 380 390 400
LDLKRPIYEK TAENGHFGHA EFPWEQPKAL KISPALIEKV KGGSVIPATS

AIAH
Length:404
Mass (Da):43,544
Last modified:January 15, 2008 - v1
Checksum:i8EA8384205B58D78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601046 Genomic DNA Translation: CAP33733.1
RefSeqiXP_002645418.1, XM_002645372.1

Genome annotation databases

EnsemblMetazoaiCBG15526; CBG15526; WBGene00035751
GeneIDi8587417
KEGGicbr:CBG15526

Similar proteinsi

Entry informationi

Entry nameiA8XM58_CAEBR
AccessioniPrimary (citable) accession number: A8XM58
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 7, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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