Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 78 (16 Jan 2019)
Sequence version 2 (16 Dec 2008)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Protein CBR-LAM-2

Gene

lam-2

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein CBR-LAM-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lam-2Imported
Synonyms:Cbr-lam-2Imported
ORF Names:CBG10982Imported, CBG_10982Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis briggsaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6238 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008549 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
CBG10982 ; CBP08685 ; WBGene00032203 ; Cbr-lam-2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500273321320 – 1646Sequence analysisAdd BLAST1627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi312 ↔ 321PROSITE-ProRule annotation
Disulfide bondi375 ↔ 384PROSITE-ProRule annotation
Disulfide bondi498 ↔ 507PROSITE-ProRule annotation
Disulfide bondi779 ↔ 788PROSITE-ProRule annotation
Disulfide bondi831 ↔ 840PROSITE-ProRule annotation
Disulfide bondi843 ↔ 857PROSITE-ProRule annotation
Disulfide bondi884 ↔ 893PROSITE-ProRule annotation
Disulfide bondi943 ↔ 952PROSITE-ProRule annotation
Disulfide bondi971 ↔ 983PROSITE-ProRule annotation
Disulfide bondi973 ↔ 990PROSITE-ProRule annotation
Disulfide bondi992 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi1019 ↔ 1031PROSITE-ProRule annotation
Disulfide bondi1021 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1040 ↔ 1049PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6238.CBG10982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8XBZ6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 286Laminin N-terminalInterPro annotationAdd BLAST240
Domaini287 – 346Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini347 – 402Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini475 – 527Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini554 – 726Laminin IV type AInterPro annotationAdd BLAST173
Domaini761 – 809Laminin EGF-likeInterPro annotationAdd BLAST49
Domaini810 – 859Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini860 – 914Laminin EGF-likeInterPro annotationAdd BLAST55
Domaini915 – 970Laminin EGF-likeInterPro annotationAdd BLAST56
Domaini971 – 1018Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1019 – 1065Laminin EGF-likeInterPro annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1077 – 1097Sequence analysisAdd BLAST21
Coiled coili1167 – 1187Sequence analysisAdd BLAST21
Coiled coili1269 – 1304Sequence analysisAdd BLAST36
Coiled coili1357 – 1394Sequence analysisAdd BLAST38
Coiled coili1500 – 1531Sequence analysisAdd BLAST32
Coiled coili1599 – 1626Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019301

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8XBZ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYSATCR

Database of Orthologous Groups

More...
OrthoDBi
156553at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 10 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 9 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8XBZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIQWLFYL AVLWQVSHPQ PAELYPSIDP NHFGADGNPC YDRSTHQPQR
60 70 80 90 100
CVPDFVNAAF NLDVQVTNTC GTKRPTKFCV QSGHTGQRSV CETCDNRHEG
110 120 130 140 150
FSHPAKFLTD FNVGNNETWW QSDTMMEGMQ FPTSVNLTLT LGKSFDITYV
160 170 180 190 200
RLKFISPRPE SFTIYKKTTA DDDWTPWQYY SGSCRATYGI PDRAPILPGN
210 220 230 240 250
ENVAQCTKEF SDISPITGGN IAFSTLEGRP SAHIFEESDV LQNWVTASAI
260 270 280 290 300
KISLNRMNTF GDEVFRDPQV LKSYYYAISD FAVGGRCKCN GHASECVGSS
310 320 330 340 350
SVDGENRLVC RCEHNTQGAD CNECLPFYND RPWKAGTANE ANECIACNCS
360 370 380 390 400
QLSNRCYFDQ QLFEQTGHGG HCIDCQGNTQ GVHCEQCVAN HWRRPGENYC
410 420 430 440 450
VACGCNEVTR ISYLKHKKDI FRSDLSLLNA TMKESVNANQ ELLDVSVISV
460 470 480 490 500
WMDTTISVLM DASHQISSSN FFRNCGCEAS GSLNNQPRCD STSGSCTCKL
510 520 530 540 550
NVEGRQCDKC KPGYFDLSTE NQFGCTPCFC FGHSSICSTA DGYFAVNVSS
560 570 580 590 600
VFEKEKENWK GQNRIGLQDA IFAELDKAVA VSDTDNSPVY FVAPQQFTGD
610 620 630 640 650
QRSSYNQDLV FTLRVTNHVT NQDVKDIIIV GADRQELSTS ITAQGNPFPS
660 670 680 690 700
NEGKTYRFRI HADPYFGWYP RINELDFIGI LSNITAIKIR GTYSYKDIGY
710 720 730 740 750
LSNVHLGSAG LAPSESNPKQ ATWIEHCECL PGFVGQFCES CEPGFRRETK
760 770 780 790 800
FGGPFNRCIK CDCHNHSNSC EAESGSCICE HNTAGDTCER CARGYYGDAL
810 820 830 840 850
QGTSEDCQKC PCPNDGPCIL HADGDVICTE CPNGYTGRRC DECSDGFFGN
860 870 880 890 900
PKDDIECNEC ACNNNTDPNS IGNCDKITGE CKKCVYNTHG FNCEKCKPGY
910 920 930 940 950
WGDALIEPKG NCRPCGCFAA GTRRPNNDYT LLECEQTDGQ CECLPNVWGM
960 970 980 990 1000
QCDQCESGFY NITSGLGCQE CGCDPLGSEG NTCDVVTGQC LCKPGVIGQH
1010 1020 1030 1040 1050
CDQCAPYHFG FSANGCQPCD CEYIGSESQQ CDVNNGQCLC KENVEGRRCD
1060 1070 1080 1090 1100
QCAENRYGIT QGCLPCDDCY TLIQSRVNTF REKVKSLDNT LQEIIENPAP
1110 1120 1130 1140 1150
VNDTKFDEKV KETSRAATEV WEAVKQKTKE GGGTIKTKSK AIKEEIMTAL
1160 1170 1180 1190 1200
EKLTTIDDSV SQARVGADAA ENDMRRWEII IENARREIEN VLHYLETEGD
1210 1220 1230 1240 1250
ERAQIAYNAS QKYGEQSKRM SELAQGTREE AEKHLKQAME IEKLSELAIA
1260 1270 1280 1290 1300
NATQANKEAS DAIYGGEQIS KQIAELKEKQ NQINESISRT LDLAEEQKKT
1310 1320 1330 1340 1350
ADEANNLAAV SLTNVEAVKI PSVDPKELKN DVAGVLEEAE NLVDSSYKEN
1360 1370 1380 1390 1400
AANDELFEEV ERTVADSRNE LQSAQDQQRV SDQLMLELEK AREKIVDSVT
1410 1420 1430 1440 1450
NADKTLKDAE AVLASLEEFT SKIEQSRNDA VAEFANVESI NKKLDGVLVA
1460 1470 1480 1490 1500
QDAKRNSLPL DRQFTADYRK SADVLLDETA VLVDKYKDLI NTEVDTQDST
1510 1520 1530 1540 1550
EAINGDIEQL MEELTESKEN LEYYRKQAED DKLMATEAVR KATLAKNSAI
1560 1570 1580 1590 1600
DANSTILSEQ DEIKKIIDAL SEYLISIGYK FNFKIFRYHG RMPNFQQYRA
1610 1620 1630 1640
DEDAKVQQLK NDITELQKEV VNLEEIRDNL PTKCFNVINL EQEGQK
Length:1,646
Mass (Da):183,353
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6124056ECC2A8D7F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HE601482 Genomic DNA Translation: CAP30235.2

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601482 Genomic DNA Translation: CAP30235.2

3D structure databases

ProteinModelPortaliA8XBZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG10982

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

WormBaseiCBG10982 ; CBP08685 ; WBGene00032203 ; Cbr-lam-2

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
HOGENOMiHOG000019301
InParanoidiA8XBZ6
OMAiFYSATCR
OrthoDBi156553at2759

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR008979 Galactose-bd-like_sf
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00180 EGF_Lam, 10 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
PROSITEiView protein in PROSITE
PS01248 EGF_LAM_1, 3 hits
PS50027 EGF_LAM_2, 9 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8XBZ6_CAEBR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8XBZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: December 16, 2008
Last modified: January 16, 2019
This is version 78 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again