Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-glucose 6-dehydrogenase

Gene

sqv-4

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.UniRule annotation

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41NADUniRule annotation1
Binding sitei46NADUniRule annotation1
Binding sitei172NADUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei283NucleophileUniRule annotation1
Binding sitei353NADUniRule annotation1
Binding sitei447SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 21NADUniRule annotation6
Nucleotide bindingi94 – 98NADUniRule annotation5
Nucleotide bindingi135 – 136NADUniRule annotation2
Nucleotide bindingi283 – 286NADUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
Gene namesi
Name:sqv-4Imported
Synonyms:Cbr-sqv-4Imported
ORF Names:CBG09668Imported, CBG_09668Imported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componenti: Chromosome V

Organism-specific databases

WormBaseiCBG09668 ; CBP02412 ; WBGene00031223 ; Cbr-sqv-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6238.CBG09668

Structurei

3D structure databases

ProteinModelPortaliA8X8I5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 452UDPG_MGDP_dh_CInterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 172Substrate bindingUniRule annotation5
Regioni227 – 231Substrate bindingUniRule annotation5
Regioni274 – 280Substrate bindingUniRule annotation7
Regioni345 – 346Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
HOGENOMiHOG000153773
InParanoidiA8X8I5
KOiK00012
OMAiRIITTNT
OrthoDBiEOG091G05RK

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

A8X8I5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDQVFGKVS KVVCVGAGYV GGPTCAMIAH KCPHVTVTVV DMNKDKIAEW
60 70 80 90 100
NSDKLPIYEP GLDEIVFAAR GRNLFFSSDI PKAIAEADLI FISVNTPTKM
110 120 130 140 150
YGRGKGMAPD LKYVESVSRT IAQYAVGPKI VVEKSTVPVK AAESIGCILR
160 170 180 190 200
EAQKNNANLK FQVLSNPEFL AEGTAMKDLA NPDRVLIGGE SSTEGLQAVA
210 220 230 240 250
ELVRIYENWV PRERIITTNT WSSELSKLVA NAFLAQRISS INSISAVCEA
260 270 280 290 300
TGAEISEVAH AVGFDTRIGN KFLKASVGFG GSCFQKDVLS LVYLCESLNL
310 320 330 340 350
PQVAEYWQGV INVNNWQRRR FADKIIAELF NTVTDKKIAI FGFAFKKNTG
360 370 380 390 400
DTRESSAIHV MKHLMEEHAK LSVYDPKVQK SQMINDLAAV TSADDVTRLV
410 420 430 440 450
TVETDPYAAA RGAHAIVVLT EWDEFVDLDY NKIHDNMQHP AAIFDGRLIL
460 470 480
DQKALREIGF RTFAIGTAPD QAYNLFGTAG Y
Length:481
Mass (Da):52,785
Last modified:January 15, 2008 - v1
Checksum:iCB57B68E492A0C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600998 Genomic DNA Translation: CAP28946.1
RefSeqiXP_002637163.1, XM_002637117.1

Genome annotation databases

EnsemblMetazoaiCBG09668; CBG09668; WBGene00031223
GeneIDi8579159
KEGGicbr:CBG09668

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600998 Genomic DNA Translation: CAP28946.1
RefSeqiXP_002637163.1, XM_002637117.1

3D structure databases

ProteinModelPortaliA8X8I5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG09668

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG09668; CBG09668; WBGene00031223
GeneIDi8579159
KEGGicbr:CBG09668

Organism-specific databases

CTDi8579159
WormBaseiCBG09668 ; CBP02412 ; WBGene00031223 ; Cbr-sqv-4

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
HOGENOMiHOG000153773
InParanoidiA8X8I5
KOiK00012
OMAiRIITTNT
OrthoDBiEOG091G05RK

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA8X8I5_CAEBR
AccessioniPrimary (citable) accession number: A8X8I5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again