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Entry version 69 (13 Nov 2019)
Sequence version 2 (16 Dec 2008)
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Protein
Submitted name:

Protein CBR-KCC-1

Gene

kcc-1

Organism
Caenorhabditis briggsae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein CBR-KCC-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kcc-1Imported
Synonyms:Cbr-kcc-1Imported
ORF Names:CBG05808Imported, CBG_05808Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis briggsaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6238 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008549 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
CBG05808a ; CBP45941 ; WBGene00028190 ; Cbr-kcc-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei141 – 166HelicalSequence analysisAdd BLAST26
Transmembranei178 – 203HelicalSequence analysisAdd BLAST26
Transmembranei224 – 252HelicalSequence analysisAdd BLAST29
Transmembranei276 – 294HelicalSequence analysisAdd BLAST19
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei436 – 457HelicalSequence analysisAdd BLAST22
Transmembranei469 – 493HelicalSequence analysisAdd BLAST25
Transmembranei571 – 590HelicalSequence analysisAdd BLAST20
Transmembranei596 – 617HelicalSequence analysisAdd BLAST22
Transmembranei629 – 647HelicalSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6238.CBG05808

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini147 – 320AA_permeaseInterPro annotationAdd BLAST174
Domaini435 – 711AA_permeaseInterPro annotationAdd BLAST277
Domaini729 – 849SLC12InterPro annotationAdd BLAST121
Domaini864 – 1106SLC12InterPro annotationAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni964 – 1039DisorderedSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi987 – 1012PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1020 – 1039PolyampholyteSequence analysisAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2082 Eukaryota
COG0531 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000092644

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8X1K8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SILACYA

Database of Orthologous Groups

More...
OrthoDBi
349744at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00324 AA_permease, 2 hits
PF03522 SLC12, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8X1K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTITNGTGPP APPSFKFVIG GDDHHQDGGS HEHSSLLATH HQVGPTAPNT
60 70 80 90 100
SGIVRHPTKV SSRFLLSVET DAPPPMTRDD SHRELYAWGS NKDAGGNHNL
110 120 130 140 150
ALFEEPSMPF FSSYLKAHIT PGPLERAQSS SHGGHGGKAD LGVLLGVYLP
160 170 180 190 200
TIQHILGVTM FIRLFWLVGI AGLGQTFLLL FLCCFCTFLT CISISAVATN
210 220 230 240 250
GVVESGGAYF MISRNLGPEF GSAVGILFYL ANTVATSMYL VGGVEILLLY
260 270 280 290 300
IFPGLTFGGS DGQHDTSLFG TMTNSLRFYS TILLLIEFAI VAMGVKFVQM
310 320 330 340 350
LAPVSLICVI LSILACYAGG ATKTMYPDSG QYVCMFNERL LQSSALHNET
360 370 380 390 400
VALDDICGYC NNNNTYLLDK VCGPEGCNDT MLARGGFSCI NGFPGFQGGK
410 420 430 440 450
TLLNNLGPNY LAKNQAAVGI PADLKVDVYQ DVRTTFFVLL AIYFPAVTGI
460 470 480 490 500
FTGANMSGDL KNPQASIPAG TIAANLTTSF IYFSLAFIFG GAIDGAVLRD
510 520 530 540 550
KNGQSVGGQM VVALLSWPSP WVLLIGSFLS TFGAALQCLC SAPRLLQAIA
560 570 580 590 600
KDEVIPILSP FKKVTANNEP FLGLILTTVI AEIAILMGSM DTIAAVVDFF
610 620 630 640 650
FLMCYAFVNI ICTLHSLLGA PNWRPRFKYY HWFLSLLGAV LCFFIMFSTH
660 670 680 690 700
WDYAIVACLL CLVIYKYVEW KGAKKEWGDG IRGLALTTAQ YSLMKIEDKE
710 720 730 740 750
PHPKNWRPQL LLLLSMQWSK EIIDVRYLNL LNLASQLKAG KGLTVVTAFL
760 770 780 790 800
KGDPTSPDDK KKGEQVKARM DFDMNQVRLR GFAKTLVHSE DQVRGSMSTL
810 820 830 840 850
VQSVGLGGLK PNTMLISWPV HEREEDMTEY NTFIEKVHAA SINDMAIVVA
860 870 880 890 900
KGIIDFPSAV FRMSGMIDVY WIVHDGGLCL LMGYLLKQHK VWRGCKLRVI
910 920 930 940 950
GIAQESDNNV KMQEDLQKYV YQLRIDAKIM IVELADPEIS KNAFERTLLM
960 970 980 990 1000
EERTMMMRDL QKVSGGGMTL SLPPNAPRAV SPLVTSEKRE NSKDSDEGTT
1010 1020 1030 1040 1050
TGSEETLDKK SPTTDNEQAN QETKTKKERM KALDRSKVSK MHTAVRLNEL
1060 1070 1080 1090 1100
LLQHSANSQL ILLNLPKPPV HKDQQALDDY VHYLEVMTDK LNRVIFVRGT

GKEVITESS
Length:1,109
Mass (Da):121,753
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CC80F656CD7149F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HE600909 Genomic DNA Translation: CAP26518.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
CBG05808b.1; CBG05808b.1; WBGene00028190

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600909 Genomic DNA Translation: CAP26518.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6238.CBG05808

Genome annotation databases

EnsemblMetazoaiCBG05808b.1; CBG05808b.1; WBGene00028190

Organism-specific databases

WormBaseiCBG05808a ; CBP45941 ; WBGene00028190 ; Cbr-kcc-1

Phylogenomic databases

eggNOGiKOG2082 Eukaryota
COG0531 LUCA
HOGENOMiHOG000092644
InParanoidiA8X1K8
OMAiSILACYA
OrthoDBi349744at2759

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR018491 SLC12_C
PfamiView protein in Pfam
PF00324 AA_permease, 2 hits
PF03522 SLC12, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8X1K8_CAEBR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8X1K8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: December 16, 2008
Last modified: November 13, 2019
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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