UniProtKB - A8WVX4 (INX19_CAEBR)
Protein
Innexin-19
Gene
inx-19
Organism
Caenorhabditis briggsae
Status
Functioni
Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling (By similarity).By similarity
GO - Molecular functioni
- gap junction channel activity Source: UniProtKB
- gap junction hemi-channel activity Source: UniProtKB
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- ion transport Source: UniProtKB-KW
- nervous system development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Ion channel |
Biological process | Differentiation, Ion transport, Neurogenesis, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Innexin-19 |
Gene namesi | Name:inx-19 ORF Names:CBG03987 |
Organismi | Caenorhabditis briggsae |
Taxonomic identifieri | 6238 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | CBG03987 ; CBP47099 ; WBGene00026740 ; Cbr-inx-19 |
Subcellular locationi
Plasma membrane
Other locations
- gap junction By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- gap junction Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 53 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 199 – 219 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 285 – 305 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341371 | 1 – 439 | Innexin-19Add BLAST | 439 |
Family & Domainsi
Sequence similaritiesi
Belongs to the pannexin family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SSX3, Eukaryota |
HOGENOMi | CLU_035763_0_1_1 |
InParanoidi | A8WVX4 |
OMAi | PISCIND |
OrthoDBi | 738314at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
A8WVX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFFHATLARS FISALSVRGD DDAVDRLNYY YTPLILAVCC LVISAKQYGG
60 70 80 90 100
TPIECWVNPH SRESMEEYIE SYCWIQNTYW IPMYENVPDD HTAREEKQIG
110 120 130 140 150
YYQWVPFILI AEALMFSLPC IFWRLCSFQS GLNIQTLINA ACDAQALLDY
160 170 180 190 200
SDRQKAVEAI TCNFVDNLDL QSPNGRIRAR GWIARIKFSR FLSGQCISIV
210 220 230 240 250
YSFTKLLYSV NVVAQFFILN ACLKSSEFVF FGFQVLSDIW AGRPWTETGH
260 270 280 290 300
FPRVTLCDFE VRYLANLNRY TVQCALLINI INEKVFAFLW CWYMILAIIT
310 320 330 340 350
TCSFIYWIAN SFIHSEKVDY VMKFIQIAES SEYKKLQKFE KDATVERLYT
360 370 380 390 400
VIAFAPHLLD SFVSDFLKSD GILMLRMISN HAGDMIVVQL VRNLWQEYRE
410 420 430
RNWREFEEHE EMKDVEMRRI QGTRERIVIA NPGQTKSFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE600906 Genomic DNA Translation: CAP24786.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HE600906 Genomic DNA Translation: CAP24786.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 6238.CBG03987 |
Organism-specific databases
WormBasei | CBG03987 ; CBP47099 ; WBGene00026740 ; Cbr-inx-19 |
Phylogenomic databases
eggNOGi | ENOG502SSX3, Eukaryota |
HOGENOMi | CLU_035763_0_1_1 |
InParanoidi | A8WVX4 |
OMAi | PISCIND |
OrthoDBi | 738314at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 1 hit |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INX19_CAEBR | |
Accessioni | A8WVX4Primary (citable) accession number: A8WVX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | October 13, 2009 | |
Last modified: | August 12, 2020 | |
This is version 59 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families