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Protein
Submitted name:

Integrin, alpha 6a

Gene

itga6a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • skeletal muscle tissue development Source: ZFIN

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-DRE-2022090 Assembly of collagen fibrils and other multimeric structures
R-DRE-210991 Basigin interactions
R-DRE-216083 Integrin cell surface interactions
R-DRE-3000157 Laminin interactions
R-DRE-446107 Type I hemidesmosome assembly

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin, alpha 6aImported
Gene namesi
Name:itga6aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-050309-23 itga6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1015 – 1037HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25UniRule annotationAdd BLAST25
ChainiPRO_500142378426 – 1092UniRule annotationAdd BLAST1067

Proteomic databases

PaxDbiA8WHQ8

Expressioni

Gene expression databases

BgeeiENSDARG00000042282
ExpressionAtlasiA8WHQ8 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000098022

Structurei

3D structure databases

ProteinModelPortaliA8WHQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 95FG-GAPPROSITE-ProRule annotationAdd BLAST65
Repeati102 – 167FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati179 – 232FG-GAPPROSITE-ProRule annotationAdd BLAST54
Repeati246 – 304FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati306 – 367FG-GAPPROSITE-ProRule annotationAdd BLAST62
Repeati368 – 425FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati428 – 488FG-GAPPROSITE-ProRule annotationAdd BLAST61
Domaini473 – 939Integrin_alpha2InterPro annotationAdd BLAST467

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBB Eukaryota
ENOG410XVGZ LUCA
GeneTreeiENSGT00760000118782
HOGENOMiHOG000015786
HOVERGENiHBG108011
InParanoidiA8WHQ8
KOiK06485
OrthoDBiEOG091G012D
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

Sequencei

Sequence statusi: Complete.

A8WHQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELFEKALSL NLCVFSWLVW TSASAFNLDT QNVLRKSGQP GSLFGFSIAL
60 70 80 90 100
HRQLQPHDKT ILLIGAPKAR ALSNQGANVT GGLYSCDITT HPNDCSRVDF
110 120 130 140 150
DNDVDVRVEN KENQWMGVTV QSQGPGGKIV TCAHRYQRLL FPNTPQEARD
160 170 180 190 200
ITGRCYMLSQ DLSIDNQSDE DGGNWKFCDG RTRGHERFGA CQQGLAATFT
210 220 230 240 250
KDYHYVIFGA PGAYNWKGIV RIEQKNNTLL EMGLFDDGPY EVGDENRLDP
260 270 280 290 300
NLVPVPANSY LGFSLDSGHS ITEKGKLIIV SGAPRANHSG AVVFLRKEGE
310 320 330 340 350
LSSMLTPEHI LEGPGLASSF GYDVAVVDLN GDGWQDVVVG APQFFQRDEE
360 370 380 390 400
VGGAVYVYIN KAGRWRDVTP VRLNGTKDSM FGLSVENIGD VNLDSFEDIA
410 420 430 440 450
VGAPYADSGF GSVYIYHGSA DGISTKPAQI LEGKQHNTKM FGYSLAGNMD
460 470 480 490 500
LDHNSYPDLA VGSLSDTVFI YRSKNVISIK KDIKVTPKEI DLTKKTCGNS
510 520 530 540 550
ICLTVEACFS YRANPTTYNP KITISCTFEA EWYRRKLGLP SRVVFLDKTE
560 570 580 590 600
IDQDYQSTGT LELRGQNKKA CYKTKLRLQD GIRDKLRAIP IEVSVAIQSA
610 620 630 640 650
KRGKRQSSLP QLVPILDSTV PNKTLTEVNF LKEGCGTDNI CQSNLNLQYR
660 670 680 690 700
FCYRESKQDI FPPLPLENGV PVISLSDQKD IALEVTVRNR NGDDAHEAKL
710 720 730 740 750
VSHFDDSLSY SGFRSLRTND KHVICAANQN GSLADCELGN PFKRDSEVTF
760 770 780 790 800
YIILSTGKIS LETKEVEIDL QLETTSSQEG LSKVKAKAKV VIELLLSVQG
810 820 830 840 850
VAKPSQVYFG GEVKGMSAMK KEEEVGSLIE YEFRVINLGK PLKSFGTASL
860 870 880 890 900
NIQWPKESSV GKWLLYLMKI NTRDLQLVTC SPEREINPLK LREDSSIRKK
910 920 930 940 950
RELEERRPSE GNKISLFTDK RKHKILSCSG DARCVEIKCP LQGLDSTAVI
960 970 980 990 1000
VLKSRLWNST FLEDFASYNY LDIIVKASIS LDVSAKNIVL KNPETQVRLT
1010 1020 1030 1040 1050
VFPETTATPF GGVPWWIILV AVLAGILMLA LLVLLLWKCG FFKRSKYEDS
1060 1070 1080 1090
VPKYHAVRIR KETRLLKDGK VMLDPFEKKQ WMTTWDENES YS
Length:1,092
Mass (Da):121,724
Last modified:January 15, 2008 - v1
Checksum:iDBEC7689C763A91C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248116 Genomic DNA No translation available.
CU469503 Genomic DNA No translation available.
RefSeqiXP_005167466.1, XM_005167409.2
UniGeneiDr.117274
Dr.77383

Genome annotation databases

EnsembliENSDART00000114168; ENSDARP00000098022; ENSDARG00000042282
GeneIDi503893
KEGGidre:503893

Similar proteinsi

Entry informationi

Entry nameiA8WHQ8_DANRE
AccessioniPrimary (citable) accession number: A8WHQ8
Secondary accession number(s): E7F087
Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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