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UniProtKB - A8WH23 (A8WH23_XENTR)
Protein
Glucose-6-phosphatase
Gene
g6pc1.2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Catalytic activityi
- EC:3.1.3.9ARBA annotation
: gluconeogenesis Pathwayi
This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 83 | SubstrateUniRule annotation | 1 | |
Active sitei | 119 | Proton donorUniRule annotation | 1 | |
Binding sitei | 169 | SubstrateUniRule annotation | 1 | |
Active sitei | 175 | NucleophileUniRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- gluconeogenesis Source: UniProtKB-UniRule
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Biological process | GluconeogenesisUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphataseUniRule annotationARBA annotation (EC:3.1.3.9UniRule annotationARBA annotation) |
Gene namesi | |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5765474, g6pc1.2 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 61 – 80 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 152 – 174 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 180 – 201 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 213 – 237 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 257 – 279 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 291 – 308 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 320 – 344 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Endoplasmic reticulumUniRule annotationARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSXETG00000013641, Expressed in embryo and 7 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 195 | acidPPcInterPro annotationAdd BLAST | 139 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QS9B, Eukaryota |
GeneTreei | ENSGT00950000183150 |
HOGENOMi | CLU_052517_0_0_1 |
OMAi | FMAAHFP |
OrthoDBi | 743717at2759 |
TreeFami | TF324388 |
Family and domain databases
InterProi | View protein in InterPro IPR016275, Glucose-6-phosphatase IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
PIRSFi | PIRSF000905, Glucose-6-phosphatase, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
i Sequence
Sequence statusi: Complete.
A8WH23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METGMENLHS TGVHIVQYLQ ENFIKSQDWF VFVSFAADLK NTFLVLFPIW
60 70 80 90 100
FHLSESVGIK LVWVAVIGDW LNLVFKWILF GQRPYWWVHE TTFFINSSAP
110 120 130 140 150
TILQFPVTCE TGPGSPSGHA MGSSSVYYVM AHAVLSILLE NKTSLMSRFQ
160 170 180 190 200
RWALWLFFWS VQVNVCLSRV FVAAHFPHQV IAGVFSGMLV AEMFNHIQCI
210 220 230 240 250
YNASFKRYLH ATLFLFFFAL GFFLLLKVFG VDLLWTLEKA KRWCARPEWI
260 270 280 290 300
HIDTTPFAGL LRNLGVFFGL GLALDTQMYR DSCRGKKSGQ FTFRLCCIMI
310 320 330 340 350
SLLVLHLFDS LELPADKEIL FYFLSFCRSV AVSLAVVAVI PYCISHALQW
QKKKVT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC154943 mRNA Translation: AAI54944.1 |
RefSeqi | NP_001106559.1, NM_001113088.1 |
Genome annotation databases
Ensembli | ENSXETT00000029871; ENSXETP00000029871; ENSXETG00000013641 |
GeneIDi | 100127753 |
KEGGi | xtr:100127753 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC154943 mRNA Translation: AAI54944.1 |
RefSeqi | NP_001106559.1, NM_001113088.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 100127753 |
Genome annotation databases
Ensembli | ENSXETT00000029871; ENSXETP00000029871; ENSXETG00000013641 |
GeneIDi | 100127753 |
KEGGi | xtr:100127753 |
Organism-specific databases
CTDi | 100127753 |
Xenbasei | XB-GENE-5765474, g6pc1.2 |
Phylogenomic databases
eggNOGi | ENOG502QS9B, Eukaryota |
GeneTreei | ENSGT00950000183150 |
HOGENOMi | CLU_052517_0_0_1 |
OMAi | FMAAHFP |
OrthoDBi | 743717at2759 |
TreeFami | TF324388 |
Enzyme and pathway databases
UniPathwayi | UPA00138 |
Gene expression databases
Bgeei | ENSXETG00000013641, Expressed in embryo and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016275, Glucose-6-phosphatase IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
PIRSFi | PIRSF000905, Glucose-6-phosphatase, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8WH23_XENTR | |
Accessioni | A8WH23Primary (citable) accession number: A8WH23 Secondary accession number(s): F6SFZ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | January 19, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |