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Entry version 90 (02 Dec 2020)
Sequence version 1 (15 Jan 2008)
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Protein
Submitted name:

Euchromatic histone lysine N-mthyltransferase EHMT2/G9a

Gene

ehmt2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Euchromatic histone lysine N-mthyltransferase EHMT2/G9aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ehmt2Imported
Synonyms:g9aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-010501-6, ehmt2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A8TT22

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini619 – 856ANK_REP_REGIONInterPro annotationAdd BLAST238
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati649 – 681ANKPROSITE-ProRule annotationAdd BLAST33
Repeati682 – 714ANKPROSITE-ProRule annotationAdd BLAST33
Repeati715 – 748ANKPROSITE-ProRule annotationAdd BLAST34
Repeati749 – 781ANKPROSITE-ProRule annotationAdd BLAST33
Repeati815 – 847ANKPROSITE-ProRule annotationAdd BLAST33
Domaini937 – 1000Pre-SETInterPro annotationAdd BLAST64
Domaini1003 – 1120SETInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 189DisorderedSequence analysisAdd BLAST189
Regioni209 – 285DisorderedSequence analysisAdd BLAST77
Regioni483 – 567DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 24PolarSequence analysisAdd BLAST16
Compositional biasi43 – 57PolarSequence analysisAdd BLAST15
Compositional biasi66 – 85PolarSequence analysisAdd BLAST20
Compositional biasi118 – 134PolyampholyteSequence analysisAdd BLAST17
Compositional biasi243 – 272PolyampholyteSequence analysisAdd BLAST30
Compositional biasi499 – 524PolarSequence analysisAdd BLAST26
Compositional biasi525 – 539PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
753093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8TT22

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043550, EHMT1/EHMT2
IPR038034, EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom

The PANTHER Classification System

More...
PANTHERi
PTHR46307, PTHR46307, 1 hit
PTHR46307:SF1, PTHR46307:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8TT22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAERALEN PSDGSSSQSS HEVEVNPAVK GKQMEDLTGR QDDGRPSTST
60 70 80 90 100
KTFTASGRAK MSVCGPGSKT PSSSSSSSSS SSAGPPAKVH RARKTMNRPP
110 120 130 140 150
LPQIKPVESV SPAAAEKPAG EEKPDADTVV KKRKAGLDVS ATPSGAPEKV
160 170 180 190 200
LKPQTEPPMT ASPAVGKAEP VAAATKDSHS RWMEDLDEEA DEEDFHLLYN
210 220 230 240 250
SYCGDDVIYS DSKSDEGMTE EPMGAGHLSD HSSSSDPPLP AYKRNSSERE
260 270 280 290 300
ENTWKRQGKG KARDRAAAGG EQDTEKGAES ASVAVGSTDY TEVPLDSLDI
310 320 330 340 350
SAADSLSHAD ISAADSLSHA DGSDAETERL EELPLCSCRM EAPRLDSSSV
360 370 380 390 400
RSSRTCMAIQ SINGELVGCT NVIMKGETMR PSSRVSLMVL CETHRSHMVK
410 420 430 440 450
HHCCPGCGYF CLSGTFLECC PDVHITHRFH RGCVSVLGSG RSRGAAGGSD
460 470 480 490 500
DQWAEPTSSG RSRGTVGVGL LFCPHCGEDA SEARTVSIPP EAPPAGSHVV
510 520 530 540 550
TASASSTTAS NHTQHTPQTH RRTTDNLNAR MRCHGDARKG AELQSQPTNG
560 570 580 590 600
AAPGSGEEDV VAVGDGGVDS VGPSLVLPNG KPVCPSALPA GDRRAALQRA
610 620 630 640 650
ILTQDSERRK KLRFHPRQLY PAAKQGEAQR VLLMLMEGMD PSYQSDSQNR
660 670 680 690 700
RCALHAAAQR GLLEICYLLV QAGAKVDAQD KSLRTPLLEA IVNNHVDVVK
710 720 730 740 750
YLIQSGACVY HAEDDGSTGL HHAAKLGNLE VVMLLLSTGQ VDINAQDSGG
760 770 780 790 800
WTPVIWAAEH RHIEVIRALL NRGADVTLRD KEMNVCLHWA SFAGSAEIAE
810 820 830 840 850
LVLNAGCPLS SVNVHGDTPL HISAREGYSD CVTLFLSRGA DIDIVNKEGD
860 870 880 890 900
TPLSLARGET PVWVALQINR KLRRGIANRI VRTERIICSD VAQGYENVPI
910 920 930 940 950
PCVNGVDDEG CPSDYKYIAE NCETSAMNID RNITHLQHCS CTDDCSSSNC
960 970 980 990 1000
LCGQLSIRCW YDKDHRLLQE FNKIEPPLIF ECNMACSCHK TCKNRVVQAG
1010 1020 1030 1040 1050
IKVRLQLYRT EKMGWGVRAL QDIPQGSFIC EYVGELISDA EADVREDDSY
1060 1070 1080 1090 1100
LFDLDNKDGE VYCIDARYYG NISRFINHLC DPNIIPVRVF MLHQDLRFPR
1110 1120 1130 1140 1150
IAFFSSRDIF TGQELGFDYG DRFWDIKSKY FTCQCGSEKC KHSAEAIALE
1160 1170
QSRLARLEVC VEPDTALSLI GHS
Length:1,173
Mass (Da):127,007
Last modified:January 15, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD24B633CB1652842
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU070918 mRNA Translation: ABW24818.1

NCBI Reference Sequences

More...
RefSeqi
NP_001107087.1, NM_001113615.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
569250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:569250

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU070918 mRNA Translation: ABW24818.1
RefSeqiNP_001107087.1, NM_001113615.1

3D structure databases

SMRiA8TT22
ModBaseiSearch...

Genome annotation databases

GeneIDi569250
KEGGidre:569250

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10919
ZFINiZDB-GENE-010501-6, ehmt2

Phylogenomic databases

OrthoDBi753093at2759
PhylomeDBiA8TT22

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043550, EHMT1/EHMT2
IPR038034, EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom
PANTHERiPTHR46307, PTHR46307, 1 hit
PTHR46307:SF1, PTHR46307:SF1, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8TT22_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8TT22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 2, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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