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UniProtKB - A8TT22 (A8TT22_DANRE)

Entry version 90 (02 Dec 2020)
Sequence version 1 (15 Jan 2008)
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Protein
Submitted name:

Euchromatic histone lysine N-mthyltransferase EHMT2/G9a

Gene

ehmt2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Euchromatic histone lysine N-mthyltransferase EHMT2/G9aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ehmt2Imported
Synonyms:g9aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-010501-6, ehmt2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A8TT22

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini619 – 856ANK_REP_REGIONInterPro annotationAdd BLAST238
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati649 – 681ANKPROSITE-ProRule annotationAdd BLAST33
Repeati682 – 714ANKPROSITE-ProRule annotationAdd BLAST33
Repeati715 – 748ANKPROSITE-ProRule annotationAdd BLAST34
Repeati749 – 781ANKPROSITE-ProRule annotationAdd BLAST33
Repeati815 – 847ANKPROSITE-ProRule annotationAdd BLAST33
Domaini937 – 1000Pre-SETInterPro annotationAdd BLAST64
Domaini1003 – 1120SETInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 189DisorderedSequence analysisAdd BLAST189
Regioni209 – 285DisorderedSequence analysisAdd BLAST77
Regioni483 – 567DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 24PolarSequence analysisAdd BLAST16
Compositional biasi43 – 57PolarSequence analysisAdd BLAST15
Compositional biasi66 – 85PolarSequence analysisAdd BLAST20
Compositional biasi118 – 134PolyampholyteSequence analysisAdd BLAST17
Compositional biasi243 – 272PolyampholyteSequence analysisAdd BLAST30
Compositional biasi499 – 524PolarSequence analysisAdd BLAST26
Compositional biasi525 – 539PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, RepeatARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		753093at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A8TT22

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043550, EHMT1/EHMT2
IPR038034, EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom

The PANTHER Classification System

More...PANTHERi		PTHR46307, PTHR46307, 1 hit
PTHR46307:SF1, PTHR46307:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8TT22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAERALEN PSDGSSSQSS HEVEVNPAVK GKQMEDLTGR QDDGRPSTST 
        60         70         80         90        100
KTFTASGRAK MSVCGPGSKT PSSSSSSSSS SSAGPPAKVH RARKTMNRPP 
       110        120        130        140        150
LPQIKPVESV SPAAAEKPAG EEKPDADTVV KKRKAGLDVS ATPSGAPEKV 
       160        170        180        190        200
LKPQTEPPMT ASPAVGKAEP VAAATKDSHS RWMEDLDEEA DEEDFHLLYN 
       210        220        230        240        250
SYCGDDVIYS DSKSDEGMTE EPMGAGHLSD HSSSSDPPLP AYKRNSSERE 
       260        270        280        290        300
ENTWKRQGKG KARDRAAAGG EQDTEKGAES ASVAVGSTDY TEVPLDSLDI 
       310        320        330        340        350
SAADSLSHAD ISAADSLSHA DGSDAETERL EELPLCSCRM EAPRLDSSSV 
       360        370        380        390        400
RSSRTCMAIQ SINGELVGCT NVIMKGETMR PSSRVSLMVL CETHRSHMVK 
       410        420        430        440        450
HHCCPGCGYF CLSGTFLECC PDVHITHRFH RGCVSVLGSG RSRGAAGGSD 
       460        470        480        490        500
DQWAEPTSSG RSRGTVGVGL LFCPHCGEDA SEARTVSIPP EAPPAGSHVV 
       510        520        530        540        550
TASASSTTAS NHTQHTPQTH RRTTDNLNAR MRCHGDARKG AELQSQPTNG 
       560        570        580        590        600
AAPGSGEEDV VAVGDGGVDS VGPSLVLPNG KPVCPSALPA GDRRAALQRA 
       610        620        630        640        650
ILTQDSERRK KLRFHPRQLY PAAKQGEAQR VLLMLMEGMD PSYQSDSQNR 
       660        670        680        690        700
RCALHAAAQR GLLEICYLLV QAGAKVDAQD KSLRTPLLEA IVNNHVDVVK 
       710        720        730        740        750
YLIQSGACVY HAEDDGSTGL HHAAKLGNLE VVMLLLSTGQ VDINAQDSGG 
       760        770        780        790        800
WTPVIWAAEH RHIEVIRALL NRGADVTLRD KEMNVCLHWA SFAGSAEIAE 
       810        820        830        840        850
LVLNAGCPLS SVNVHGDTPL HISAREGYSD CVTLFLSRGA DIDIVNKEGD 
       860        870        880        890        900
TPLSLARGET PVWVALQINR KLRRGIANRI VRTERIICSD VAQGYENVPI 
       910        920        930        940        950
PCVNGVDDEG CPSDYKYIAE NCETSAMNID RNITHLQHCS CTDDCSSSNC 
       960        970        980        990       1000
LCGQLSIRCW YDKDHRLLQE FNKIEPPLIF ECNMACSCHK TCKNRVVQAG 
      1010       1020       1030       1040       1050
IKVRLQLYRT EKMGWGVRAL QDIPQGSFIC EYVGELISDA EADVREDDSY 
      1060       1070       1080       1090       1100
LFDLDNKDGE VYCIDARYYG NISRFINHLC DPNIIPVRVF MLHQDLRFPR 
      1110       1120       1130       1140       1150
IAFFSSRDIF TGQELGFDYG DRFWDIKSKY FTCQCGSEKC KHSAEAIALE 
      1160       1170 
QSRLARLEVC VEPDTALSLI GHS
Length:1,173
Mass (Da):127,007
Last modified:January 15, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD24B633CB1652842
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EU070918 mRNA Translation: ABW24818.1

NCBI Reference Sequences

More...RefSeqi		NP_001107087.1, NM_001113615.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		569250

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:569250

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU070918 mRNA Translation: ABW24818.1
RefSeqiNP_001107087.1, NM_001113615.1

3D structure databases

SMRiA8TT22
ModBaseiSearch...

Genome annotation databases

GeneIDi569250
KEGGidre:569250

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10919
ZFINiZDB-GENE-010501-6, ehmt2

Phylogenomic databases

OrthoDBi753093at2759
PhylomeDBiA8TT22

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR043550, EHMT1/EHMT2
IPR038034, EHMT2
IPR007728, Pre-SET_dom
IPR001214, SET_dom
PANTHERiPTHR46307, PTHR46307, 1 hit
PTHR46307:SF1, PTHR46307:SF1, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF05033, Pre-SET, 1 hit
PF00856, SET, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00468, PreSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS50867, PRE_SET, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8TT22_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8TT22
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 2, 2020
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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