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Entry version 64 (07 Oct 2020)
Sequence version 1 (15 Jan 2008)
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Protein
Submitted name:

Complement-depleting factor

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi507Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi530MagnesiumUniRule annotation1
Metal bindingi531Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi533MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Complement-depleting factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOphiophagus hannah (King cobra) (Naja hannah)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8665 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500272537223 – 1641Sequence analysisAdd BLAST1619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi535 ↔ 796Interchain (between beta and alpha chains)UniRule annotation
Disulfide bondi604 ↔ 639UniRule annotation
Disulfide bondi672 ↔ 699UniRule annotation
Disulfide bondi673 ↔ 706UniRule annotation
Disulfide bondi686 ↔ 707UniRule annotation
Disulfide bondi852 ↔ 1491UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki989 ↔ 992Isoglutamyl cysteine thioester (Cys-Gln)UniRule annotation
Disulfide bondi1081 ↔ 1137UniRule annotation
Disulfide bondi1336 ↔ 1467UniRule annotation
Disulfide bondi1367 ↔ 1436UniRule annotation
Disulfide bondi1484 ↔ 1489UniRule annotation
Disulfide bondi1496 ↔ 1568UniRule annotation
Disulfide bondi1515 ↔ 1639UniRule annotation
Disulfide bondi1615 ↔ 1624UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationARBA annotation, Thioester bondUniRule annotationARBA annotation

Proteomic databases

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
A8QL55

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini672 – 707Anaphylatoxin-likeInterPro annotationAdd BLAST36
Domaini1496 – 1639NTRInterPro annotationAdd BLAST144

Keywords - Domaini

SignalSequence analysisARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017, ANATO, 1 hit
cd03583, NTR_complement_C3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR001840, Anaphylatoxn_comp_syst_dom
IPR041425, C3/4/5_MG1
IPR035711, Complement_C3-like
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR035815, NTR_complement_C3
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF81, PTHR11412:SF81, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF17790, MG1, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00004, ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8QL55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGMALYLVA ALLIGFPGSS HGALYTLITP GVLRTDTEEQ ILVEAHGDNT
60 70 80 90 100
PKQLDIFVHD FPRKQKILFQ KRVDMNPAGD MLVTPTIKIP AEEVSKDSRQ
110 120 130 140 150
NQYVVVQVTG PQVRLEKVVL LSYQSGFVFI QTDKGIYTPG SPVLYRVFSM
160 170 180 190 200
DHNMRQMDKT VVVEFQTPEG IVVSSNRIDL NFTRPYNLPE LGSLGTWKIV
210 220 230 240 250
AKYEHSPENY TAYFDVRKYV LPSFEVHLQP SEKSFYIDGN ENFHVSITAR
260 270 280 290 300
YLYGEEVEGV AFVLFGVKID GAKKSIPDSL TRIPILDGDG EATLKRDTLR
310 320 330 340 350
SRFPNLNELV GHTLYASVTV ITESGSDMVA TEQSGIHIVT SPYQIYFTKT
360 370 380 390 400
PKYFKPGMPY ELTVYVTNPD GSPAAKVPVV SEAIHSEGTT LSDGTAKLIL
410 420 430 440 450
NTPLDTQSLL ITVRTNHGDL PRERQATKSM TATAYQTQGG SGNYLHVAIT
460 470 480 490 500
STEIKPGDNL PVNFNVRGNA NSLNQVKYFT YLVGRQPKGA GQNLVAMNLR
510 520 530 540 550
ITPDLIPSFR FVAYYQVGNN EIVADSVWVD VKDTCMGMLV VKGASSRDNR
560 570 580 590 600
IHMPGAAVKI NWKGIQVLKS VLWLWIKQYM FSMINIKISQ AKIWDTIEKS
610 620 630 640 650
DFGCTAGSGQ NNLGVFEDAG LALTTSTNLN TKQRSDTKCP QPANRRRSSS
660 670 680 690 700
VLLLDSKASK AAQFQDQDLR KCCEDSMHEN PMGYTCEKRA KYIQEGDACK
710 720 730 740 750
AAFLECCRYI KGILDENQWE SGLFLPRNDN EDGFIQDSDI IPRTDFPKSW
760 770 780 790 800
LWHTVQLTEQ PNSNGISSKT MSIYLKESIT TWEVLAVSFT PTKGICVAEP
810 820 830 840 850
YEITVMKDFF IDLRVPYSVV RNEQVEIRAV LYNYADEDIY VRVELLYNPA
860 870 880 890 900
FCSASTEEQR YRQQFTIKAL SSRAVPFVIV PLQQGLHDIE VRASVQGWES
910 920 930 940 950
VSDGVKKKLK VVPEGVQKCI VTIIKLDPRA KGVDGTQREV VKARKLDDKV
960 970 980 990 1000
PGTEIETKIT IQADPVAQII ENSIDGSKLN HLIITPSGCG EQNMIRMTAP
1010 1020 1030 1040 1050
VIATYYLDTT EQWETLGRNH RNEAVKQIMT GYAQQMVYKK ANHSYAAFTN
1060 1070 1080 1090 1100
RASSTWLTAY VVKVFAMATK MVAGISHEII CGGVRWLILN RQQPDGAFKE
1110 1120 1130 1140 1150
NAPVLSGTMQ GGIQGDESEV TVTAFTLVAL LESKTICNDS VNSLDSSIKK
1160 1170 1180 1190 1200
ATDYLLKKYE KLQRPYTTAL TAYALAAADR LNDDRVLMAA STGKNRWEEY
1210 1220 1230 1240 1250
NAHTHNVEGT SYALLALLKM KKFDQTGPIV RWLTDQNFYG GTYGQTQATV
1260 1270 1280 1290 1300
MLFQALAEYK IQMPTHKDLN LDIIIKLPER ELPLHYRLDA TNAILARTAE
1310 1320 1330 1340 1350
TKLNQDFTVS ASGDGTATMT ILTVYNAQLQ EKANVCNKFH LDVSVENIHL
1360 1370 1380 1390 1400
NFKHAKGAKG ALMLKICMRY LGEVDSTMTI IDISMLTGFL PDAEDLTRLS
1410 1420 1430 1440 1450
EGVDRYISRY EVDNNMAQKV AVIIYLDKVS HSEDECLQFK ILKHFEVGFI
1460 1470 1480 1490 1500
QPGSVKVYSY YNLDEQCTKF YHPDKGTGLL NKICVGNICR CAAETCSLLS
1510 1520 1530 1540 1550
QQEKIDLPLR IQKACASNVD YVYKTKLLRI EEKDGYDIYV MDVLEVIKPG
1560 1570 1580 1590 1600
TDENPQANAR QYISQRKCQE ALNLNVNDDY LIWGLRSDLW PMKDKFSYLI
1610 1620 1630 1640
TKNTWIERWP HEDECQDEEF QNLCLDFAHL SNILTIFGCP T
Length:1,641
Mass (Da):184,354
Last modified:January 15, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6FA3C52C003664D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF080836 mRNA Translation: ABN72543.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF080836 mRNA Translation: ABN72543.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiI39.950

Proteomic databases

TopDownProteomicsiA8QL55

Family and domain databases

CDDicd00017, ANATO, 1 hit
cd03583, NTR_complement_C3, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR001840, Anaphylatoxn_comp_syst_dom
IPR041425, C3/4/5_MG1
IPR035711, Complement_C3-like
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR035815, NTR_complement_C3
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold
PANTHERiPTHR11412:SF81, PTHR11412:SF81, 1 hit
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF17790, MG1, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit
PRINTSiPR00004, ANAPHYLATOXN
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit
SUPFAMiSSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8QL55_OPHHA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8QL55
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 7, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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