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Entry version 50 (10 Apr 2019)
Sequence version 1 (15 Jan 2008)
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Protein

Elongator complex protein 1

Gene

MGL_2517

Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongator complex protein 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:MGL_2517Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMalassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated fungus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri425265 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaMalasseziomycetesMalassezialesMalasseziaceaeMalassezia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008837 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:MGL_2517

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1194 – 1232Sequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ELP1/IKA1 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1920 Eukaryota
COG5290 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8Q4A7

KEGG Orthology (KO)

More...
KOi
K11373

Database of Orthologous Groups

More...
OrthoDBi
180136at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006849 Elp1
IPR011990 TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12747 PTHR12747, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04762 IKI3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017233 IKAP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8Q4A7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCVADFRLL PDGGSTVDHV PALCIVCTGG DIVLLPVGGD EAAPADVVGC
60 70 80 90 100
VDQGILAAAW SPEEDLLTIV TGGEKRLLIM TREFEVVSES ILVTDTFGDD
110 120 130 140 150
QPVNVGWGSK STQFHGSEGK QAAMAAAQEP ASGDPRGPLV PDDDGLPRIS
160 170 180 190 200
WRGDGSFFVI SNAEPFSDTT ALHRVLRVYT RSGTLSATSD RSVRGISHVL
210 220 230 240 250
ACRPTGNLIA TSQRMGGDYA PGRQGRHDIV FFERNGLRHG EFSLREEHGA
260 270 280 290 300
CPDVLHGTAP LPPWSCEHQI KALAWNADGS VLAVHLQRGS DHVLQLWTSG
310 320 330 340 350
NYHWYLKHES VYEGMLNHLS WHPEQPWTLY VAAHGRVEKR TMWLETACSR
360 370 380 390 400
GPPPHDAACA AVVDGHALYL TPFRRENVPP PMCSVAIFDS PDTHAHAPPE
410 420 430 440 450
TPIHVAWTTD VDADGNTSDL VALLYSQGVV HVWRLPYGSL SAAQPRPRAP
460 470 480 490 500
LLPECIRTLT VPRDTYPYQV ALSSKSSSLT VAVLATDGDN AAVWMLSDSE
510 520 530 540 550
ESQPVRVTLD GHGPRRLVSV PSSAAFALHD DRGDVTRLAP TEPPTPLDPL
560 570 580 590 600
LAFCPTLHVL DMDETLMPVG LAADSRLLAP DRVLAKDATS FTSTNGLLIW
610 620 630 640 650
TTHSHEVKFL PLSALSTTPN IVQLSRRVER GSRIVTAVPS AMSLVLQIPR
660 670 680 690 700
GNLETTYPRP MVLDVIRSKL DQCLFGDALR LSRAHRVDLN LLHDHNPTAF
710 720 730 740 750
LSNVPEILHQ VDNIDHLNLL LSNLRNEDVT QTLYKPWDPS SHTPVRDLDT
760 770 780 790 800
KVNRICDVFL DAFQSADERR FLSCILTAHV RKVPPDYEGG LRVLLKYIDT
810 820 830 840 850
DPPLAEEACK YIIFLVSADQ LYKVALGMYD LSLALMIAQQ SPRDPREYVP
860 870 880 890 900
FLRDLRSKEP LEYQRFCIDD HLGHHAKALA WLARSGDESR MESAMAYMVQ
910 920 930 940 950
HKLYREGLKA FANDPERLRE AYARFGDYLS SHQRAAEAAT AYELAGRLID
960 970 980 990 1000
AMNAYKEADQ WQQALTLAQK TRMAGPELTH FMRSLAEQLE EQHKYEQAAR
1010 1020 1030 1040 1050
VLLRLPDMEA GIELLCRAHA FVDAQYECAA HDRWDLMETH VAPGLLETQS
1060 1070 1080 1090 1100
SLLEEASEIE EQMTKQVRRL FELDAKRDED PSAFYVSEDV QALNNVEVSS
1110 1120 1130 1140 1150
DMSQMTQFTR YTTATSVAPS MSTLSLGSKS RQRAKAKKEE KKKNAGKKGS
1160 1170 1180 1190 1200
VYEEGYLHES LQKLLQTRLG TLQKDTARLL PVLVMFGERH RLAAQELQQR
1210 1220 1230 1240 1250
LLALEQSARR AAADLEERYA RQMQDRAETT QALAAQVTQL AHGPGAPSET
1260 1270 1280
ASSTLSTLWR WRQMQEPKKA PTVSHESWKL HLLEEV
Length:1,286
Mass (Da):142,820
Last modified:January 15, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB170C5B0CD1F53CC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAYY01000009 Genomic DNA Translation: EDP42921.1

NCBI Reference Sequences

More...
RefSeqi
XP_001730135.1, XM_001730083.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EDP42921; EDP42921; MGL_2517

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5854442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mgl:MGL_2517

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAYY01000009 Genomic DNA Translation: EDP42921.1
RefSeqiXP_001730135.1, XM_001730083.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEDP42921; EDP42921; MGL_2517
GeneIDi5854442
KEGGimgl:MGL_2517

Organism-specific databases

EuPathDBiFungiDB:MGL_2517

Phylogenomic databases

eggNOGiKOG1920 Eukaryota
COG5290 LUCA
InParanoidiA8Q4A7
KOiK11373
OrthoDBi180136at2759

Family and domain databases

InterProiView protein in InterPro
IPR006849 Elp1
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR12747 PTHR12747, 1 hit
PfamiView protein in Pfam
PF04762 IKI3, 1 hit
PIRSFiPIRSF017233 IKAP, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8Q4A7_MALGO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8Q4A7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 10, 2019
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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