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UniProtKB - A8NE23 (COP3_COPC7)
Protein
Alpha-muurolene synthase
Gene
COP3
Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)
Status
Functioni
Sesquiterpene synthase that catalyzes the formation of alpha-muurolene, and at lower level (+)-(R)-germacrene A and gamma-muurolene.
2 PublicationsCatalytic activityi
Cofactori
Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 97 | Magnesium 1By similarity | 1 | |
Metal bindingi | 97 | Magnesium 2By similarity | 1 | |
Metal bindingi | 101 | Magnesium 1By similarity | 1 | |
Metal bindingi | 101 | Magnesium 2By similarity | 1 | |
Metal bindingi | 240 | Magnesium 3By similarity | 1 | |
Metal bindingi | 244 | Magnesium 3By similarity | 1 | |
Metal bindingi | 248 | Magnesium 3By similarity | 1 |
GO - Molecular functioni
- germacrene-A synthase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Lyase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 4.2.3.125, 1606 4.2.3.126, 1606 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:COP3 ORF Names:CC1G_12294 |
Organismi | Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) |
Taxonomic identifieri | 240176 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Agaricomycetes › Agaricomycetidae › Agaricales › Psathyrellaceae › Coprinopsis › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:CC1G_12294 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 251 | K → I: Weak effect on catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 255 | H → P: Increased synthesis by of the cis pathway product delta-cadinene 8. 1 Publication | 1 | |
Mutagenesisi | 256 | N → L: Loss of catalytic activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000419683 | 1 – 425 | Alpha-muurolene synthaseAdd BLAST | 425 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 348 – 382 | DisorderedSequence analysisAdd BLAST | 35 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 97 – 101 | DDXXD motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 348 – 363 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 367 – 381 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.By similarity
Sequence similaritiesi
Belongs to the terpene synthase family.Curated
Phylogenomic databases
eggNOGi | ENOG502S2X0, Eukaryota |
HOGENOMi | CLU_042538_2_1_1 |
InParanoidi | A8NE23 |
OMAi | DLIEYAM |
OrthoDBi | 1143139at2759 |
Family and domain databases
Gene3Di | 1.10.600.10, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034686, Terpene_cyclase-like_2 |
SFLDi | SFLDG01020, Terpene_Cyclase_Like_2, 1 hit |
SUPFAMi | SSF48576, SSF48576, 1 hit |
i Sequence
Sequence statusi: Complete.
A8NE23-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTPSSSLTT DESPASFILP DLVSHCPFPL RYHPKGDEVA KQTVHWLDSN
60 70 80 90 100
CPDLTAKERK AMYGLQAGEL TGYCYPYTTP ERLRVVADFL NYLFHLDNIS
110 120 130 140 150
DGMMTRETAV LADVVMNALW FPEDYRPTKG QAAEELNPGK LARDFWSRCI
160 170 180 190 200
PDCGPGTQAR FKETFGSFFE AVNIQARARD EGVIPDLESY IDVRRDTSGC
210 220 230 240 250
KPCWVLIEYA LGIDLPDFVV EHPVIAALNQ GTNDLVTWSN DIFSYNVEQS
260 270 280 290 300
KGDTHNMIII LMEHHGHTLQ SAVDYVGSLC QQTINTFCEN KQQLPSWGPE
310 320 330 340 350
IDDMVAKYVQ GLEDWIVGSL HWSFQTRRYF GDEGQEIKQH RLVKLLTVAP
360 370 380 390 400
PPPPPPPTPP PQSSDADTKK QKVKAQDGKG PVSDEEVWAL VRAEQSKGSI
410 420
LESLFGFLTT SLSRIFFGYF FAYSH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACS02000002 Genomic DNA Translation: EAU88892.1 |
RefSeqi | XP_001832925.1, XM_001832873.1 |
Genome annotation databases
EnsemblFungii | EAU88892; EAU88892; CC1G_12294 |
GeneIDi | 6009414 |
KEGGi | cci:CC1G_12294 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACS02000002 Genomic DNA Translation: EAU88892.1 |
RefSeqi | XP_001832925.1, XM_001832873.1 |
3D structure databases
AlphaFoldDBi | A8NE23 |
SMRi | A8NE23 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5346.XP_001832925.1 |
Genome annotation databases
EnsemblFungii | EAU88892; EAU88892; CC1G_12294 |
GeneIDi | 6009414 |
KEGGi | cci:CC1G_12294 |
Organism-specific databases
VEuPathDBi | FungiDB:CC1G_12294 |
Phylogenomic databases
eggNOGi | ENOG502S2X0, Eukaryota |
HOGENOMi | CLU_042538_2_1_1 |
InParanoidi | A8NE23 |
OMAi | DLIEYAM |
OrthoDBi | 1143139at2759 |
Enzyme and pathway databases
BRENDAi | 4.2.3.125, 1606 4.2.3.126, 1606 |
Family and domain databases
Gene3Di | 1.10.600.10, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR034686, Terpene_cyclase-like_2 |
SFLDi | SFLDG01020, Terpene_Cyclase_Like_2, 1 hit |
SUPFAMi | SSF48576, SSF48576, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COP3_COPC7 | |
Accessioni | A8NE23Primary (citable) accession number: A8NE23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2012 |
Last sequence update: | January 15, 2008 | |
Last modified: | May 25, 2022 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families