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UniProtKB - A8MZA4 (GG6L6_HUMAN)

Entry version 84 (02 Jun 2021)
Sequence version 4 (20 Jan 2016)
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Protein

Golgin subfamily A member 6-like protein 6

Gene

GOLGA6L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A8MZA4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 6-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA6L6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:37225, GOLGA6L6

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A8MZA4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000277322

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A8MZA4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GOLGA6L6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322671 – 724Golgin subfamily A member 6-like protein 6Add BLAST724

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A8MZA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A8MZA4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A8MZA4

PeptideAtlas

More...PeptideAtlasi		A8MZA4

PRoteomics IDEntifications database

More...PRIDEi		A8MZA4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2465

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A8MZA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A8MZA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000277322, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480376

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A8MZA4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A8MZA4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 108DisorderedSequence analysisAdd BLAST108
Regioni314 – 342DisorderedSequence analysisAdd BLAST29
Regioni374 – 454DisorderedSequence analysisAdd BLAST81
Regioni517 – 548DisorderedSequence analysisAdd BLAST32
Regioni561 – 724DisorderedSequence analysisAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili164 – 686Sequence analysisAdd BLAST523

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 32Pro residuesSequence analysisAdd BLAST24
Compositional biasi43 – 57Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi58 – 95Polar residuesSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLGA6 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4725, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163338

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A8MZA4

Identification of Orthologs from Complete Genome Data

More...OMAi		REAHIME

Database of Orthologous Groups

More...OrthoDBi		358120at2759

TreeFam database of animal gene trees

More...TreeFami		TF316990

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026737, GOLGA6L

The PANTHER Classification System

More...PANTHERi		PTHR23143, PTHR23143, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8MZA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMWPQPHLP THPHLPTHPH LPTHPHLPTH PHLPTHPMMS KETRQSKLAE 
        60         70         80         90        100
AKEQLTDHHP QTNPSVGTAA SDTKKKKINN GTNPETTTSG GCHSPEDEQK 
       110        120        130        140        150
ASHQHQEALR RELEAQVHTI RILTCQKTEL QMALYYSQHA VKQLEGEARD 
       160        170        180        190        200
LISRLHDSWK FAGELEQALS AVATQKKKAD RYIEELTKER DALSLELYRN 
       210        220        230        240        250
TITDEELKEK NAELQEKLQL VESEKSEIQL NVKELKRKLE RAKLLLPQQQ 
       260        270        280        290        300
LQAEADHLGK ELQSVSAKLQ AQVEENELWN RLNQQQEEKM WRQEEKIQEW 
       310        320        330        340        350
EEKIQEQEEK IREQEEKIRE QEEKMRRQEE MMWEKEEKMR RQEEMMWEKE 
       360        370        380        390        400
EKMRRQEEMM WEKEEKIREL EEKMHEQEKI REQEEKRQEE EKIREQEKRQ 
       410        420        430        440        450
EQEAKMWRQE EKIREQEEKI REQEKKMWRQ EEKIHEQEKI REEEKRQEQE 
       460        470        480        490        500
EMWRQEEKIR EQEEIWRQKE KMHEQEEKIR KQEEKVWRQE EKIREQEEKI 
       510        520        530        540        550
REQEEKMWRQ EEKIREQEEM WREEEKMHEQ EKIWEEEKRQ EQEDKMWRQE 
       560        570        580        590        600
EKIREQEEKV WRQEEKIREQ EEKRQEQEEK MWKQEEKIRE QEEKIREQEE 
       610        620        630        640        650
KIREQEEKIR EQEEMTQEQE EKMGEQEEKM CEQEEKMQEQ EETMWRQEEK 
       660        670        680        690        700
IREQEKKIRE QEEKIREQEE MMQEQEEKMW EQEEKMCEQE EKMQEQEEKM 
       710        720 
RRQEEKMWEQ EVRLRQQEEK MQEH
Length:724
Mass (Da):90,952
Last modified:January 20, 2016 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88688B5499BA2745
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC023310 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45184.1

NCBI Reference Sequences

More...RefSeqi		NP_001138476.2, NM_001145004.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000619213; ENSP00000480376; ENSG00000277322

Database of genes from NCBI RefSeq genomes

More...GeneIDi		727832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:727832

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023310 Genomic DNA No translation available.
CCDSiCCDS45184.1
RefSeqiNP_001138476.2, NM_001145004.2

3D structure databases

SMRiA8MZA4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000480376

PTM databases

iPTMnetiA8MZA4
PhosphoSitePlusiA8MZA4

Genetic variation databases

BioMutaiGOLGA6L6

Proteomic databases

EPDiA8MZA4
MassIVEiA8MZA4
PaxDbiA8MZA4
PeptideAtlasiA8MZA4
PRIDEiA8MZA4
ProteomicsDBi2465

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		78143, 2 antibodies

Genome annotation databases

EnsembliENST00000619213; ENSP00000480376; ENSG00000277322
GeneIDi727832
KEGGihsa:727832

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		727832

GeneCards: human genes, protein and diseases

More...GeneCardsi		GOLGA6L6
HGNCiHGNC:37225, GOLGA6L6
HPAiENSG00000277322, Tissue enriched (testis)
neXtProtiNX_A8MZA4
OpenTargetsiENSG00000277322

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4725, Eukaryota
GeneTreeiENSGT00940000163338
InParanoidiA8MZA4
OMAiREAHIME
OrthoDBi358120at2759
TreeFamiTF316990

Enzyme and pathway databases

PathwayCommonsiA8MZA4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		727832, 141 hits in 541 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		727832
PharosiA8MZA4, Tdark

Protein Ontology

More...PROi		PR:A8MZA4
RNActiA8MZA4, protein

Family and domain databases

InterProiView protein in InterPro
IPR026737, GOLGA6L
PANTHERiPTHR23143, PTHR23143, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGG6L6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MZA4
Secondary accession number(s): D3YTC0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 20, 2016
Last modified: June 2, 2021
This is version 84 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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