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Protein

Uncharacterized protein C2orf74

Gene

C2orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C2orf74
Gene namesi
Name:C2orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000237651.6
HGNCiHGNC:34439 C2orf74
neXtProtiNX_A8MZ97

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000237651
PharmGKBiPA162379547

Polymorphism and mutation databases

BioMutaiC2orf74

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003435661 – 194Uncharacterized protein C2orf74Add BLAST194

Proteomic databases

EPDiA8MZ97
MaxQBiA8MZ97
PaxDbiA8MZ97
PRIDEiA8MZ97
ProteomicsDBi2463

PTM databases

iPTMnetiA8MZ97
PhosphoSitePlusiA8MZ97

Expressioni

Gene expression databases

BgeeiENSG00000237651 Expressed in 90 organ(s), highest expression level in caudate nucleus
CleanExiHS_C2orf74
ExpressionAtlasiA8MZ97 baseline and differential
GenevisibleiA8MZ97 HS

Organism-specific databases

HPAiHPA026826

Interactioni

Protein-protein interaction databases

BioGridi130940, 1 interactor
IntActiA8MZ97, 2 interactors
STRINGi9606.ENSP00000402915

Structurei

3D structure databases

ProteinModelPortaliA8MZ97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCBD Eukaryota
ENOG41115I9 LUCA
GeneTreeiENSGT00390000004911
HOGENOMiHOG000111333
HOVERGENiHBG107583
InParanoidiA8MZ97
OMAiICFICIL
OrthoDBiEOG091G0ZA5
PhylomeDBiA8MZ97

Family and domain databases

InterProiView protein in InterPro
IPR027813 DUF4642
PANTHERiPTHR37882 PTHR37882, 1 hit
PfamiView protein in Pfam
PF15484 DUF4642, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A8MZ97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLAKPMSF ETTAITFFII LLICLICILL LLVVFLYKCF QGRKGKETKK
60 70 80 90 100
VPCTDANGGV DCAAAKVVTS NPEDHERILM QVMNLNVPMR PGILVQRQSK
110 120 130 140 150
EVLATPLENR RDMEAEEENQ INEKQEPENA GETGQEEDDG LQKIHTSVTR
160 170 180 190
TPSVVESQKR PLKGVTFSRE VIVVDLGNEY PTPRSYTREH KERK
Length:194
Mass (Da):21,915
Last modified:November 24, 2009 - v3
Checksum:iDD90134F5F912145
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1C3A0A087X1C3_HUMAN
Uncharacterized protein C2orf74
C2orf74
187Annotation score:
C9JBF1C9JBF1_HUMAN
Uncharacterized protein C2orf74
C2orf74
115Annotation score:
A0A087WXS6A0A087WXS6_HUMAN
Uncharacterized protein C2orf74
C2orf74
28Annotation score:
F8VY72F8VY72_HUMAN
Uncharacterized protein C2orf74
C2orf74
52Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016747 Genomic DNA No translation available.
RefSeqiNP_001137431.1, NM_001143959.1
UniGeneiHs.140617

Genome annotation databases

EnsembliENST00000432605; ENSP00000402915; ENSG00000237651
GeneIDi339804
KEGGihsa:339804
UCSCiuc010ypm.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016747 Genomic DNA No translation available.
RefSeqiNP_001137431.1, NM_001143959.1
UniGeneiHs.140617

3D structure databases

ProteinModelPortaliA8MZ97
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130940, 1 interactor
IntActiA8MZ97, 2 interactors
STRINGi9606.ENSP00000402915

PTM databases

iPTMnetiA8MZ97
PhosphoSitePlusiA8MZ97

Polymorphism and mutation databases

BioMutaiC2orf74

Proteomic databases

EPDiA8MZ97
MaxQBiA8MZ97
PaxDbiA8MZ97
PRIDEiA8MZ97
ProteomicsDBi2463

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432605; ENSP00000402915; ENSG00000237651
GeneIDi339804
KEGGihsa:339804
UCSCiuc010ypm.1 human

Organism-specific databases

CTDi339804
EuPathDBiHostDB:ENSG00000237651.6
GeneCardsiC2orf74
HGNCiHGNC:34439 C2orf74
HPAiHPA026826
neXtProtiNX_A8MZ97
OpenTargetsiENSG00000237651
PharmGKBiPA162379547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCBD Eukaryota
ENOG41115I9 LUCA
GeneTreeiENSGT00390000004911
HOGENOMiHOG000111333
HOVERGENiHBG107583
InParanoidiA8MZ97
OMAiICFICIL
OrthoDBiEOG091G0ZA5
PhylomeDBiA8MZ97

Miscellaneous databases

ChiTaRSiC2orf74 human
GenomeRNAii339804
PROiPR:A8MZ97

Gene expression databases

BgeeiENSG00000237651 Expressed in 90 organ(s), highest expression level in caudate nucleus
CleanExiHS_C2orf74
ExpressionAtlasiA8MZ97 baseline and differential
GenevisibleiA8MZ97 HS

Family and domain databases

InterProiView protein in InterPro
IPR027813 DUF4642
PANTHERiPTHR37882 PTHR37882, 1 hit
PfamiView protein in Pfam
PF15484 DUF4642, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCB074_HUMAN
AccessioniPrimary (citable) accession number: A8MZ97
Secondary accession number(s): C9JP62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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