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Protein

Leucine-twenty homeobox

Gene

LEUTX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi3 – 37HomeoboxPROSITE-ProRule annotationAdd BLAST35

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-twenty homeobox
Gene namesi
Name:LEUTX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213921.6
HGNCiHGNC:31953 LEUTX
neXtProtiNX_A8MZ59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi342900
OpenTargetsiENSG00000213921

Polymorphism and mutation databases

BioMutaiLEUTX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003438911 – 168Leucine-twenty homeoboxAdd BLAST168

Proteomic databases

PaxDbiA8MZ59
PRIDEiA8MZ59
ProteomicsDBi2455

Expressioni

Gene expression databases

BgeeiENSG00000213921 Expressed in 2 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiA8MZ59 baseline and differential

Organism-specific databases

HPAiHPA041498

Interactioni

Protein-protein interaction databases

IntActiA8MZ59, 43 interactors
STRINGi9606.ENSP00000380053

Structurei

3D structure databases

ProteinModelPortaliA8MZ59
SMRiA8MZ59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00490000044215
HOGENOMiHOG000203643
InParanoidiA8MZ59
OMAiFPVCLEY
OrthoDBiEOG091G0PQK
PhylomeDBiA8MZ59

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

A8MZ59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPSLATMGK LASKLQLDLS VVKIWFKNQR AKWKRQQRQQ MQTRPSLGPA
60 70 80 90 100
NQTTSVKKEE TPSAITTANI RPVSPGISDA NDHDLREPSG IKNPGGASAS
110 120 130 140 150
ARVSSWDSQS YDIEQICLGA SNPPWASTLF EIDEFVKIYD LPGEDDTSSL
160
NQYLFPVCLE YDQLQSSV
Length:168
Mass (Da):18,626
Last modified:March 8, 2011 - v3
Checksum:i400324258F92BEAC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQ33A0A1W2PQ33_HUMAN
Leucine-twenty homeobox
LEUTX
198Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73V → E in DY655817 (Ref. 3) Curated1
Sequence conflicti98S → T in DY655817 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005393 Genomic DNA No translation available.
CR746510 mRNA No translation available.
DY655817 mRNA No translation available.
RefSeqiNP_001137304.1, NM_001143832.1
UniGeneiHs.451638

Genome annotation databases

EnsembliENST00000396841; ENSP00000380053; ENSG00000213921
ENST00000629267; ENSP00000486698; ENSG00000280774
GeneIDi342900
KEGGihsa:342900
UCSCiuc010xvg.3 human

Similar proteinsi

Entry informationi

Entry nameiLEUTX_HUMAN
AccessioniPrimary (citable) accession number: A8MZ59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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