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Entry version 95 (12 Aug 2020)
Sequence version 4 (22 Apr 2020)
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Protein

Paired-like homeodomain transcription factor LEUTX

Gene

LEUTX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Paired-like homeobox transcription factor involved in embryogenesis (PubMed:27578796, PubMed:30479355). May act as a regulator of embryo genome activation (PubMed:27578796). Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos (PubMed:27578796, PubMed:30479355).2 Publications
Inactive transcriptional activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei54Required for binding to the 5'-TAATCC-3' sequence1 Publication1
Sitei57Required for binding to the 5'-TAATCC-3' sequence1 Publication1
Sitei61Required for binding to the 5'-TAATCC-3' sequence1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi33 – 67HomeoboxPROSITE-ProRule annotationAdd BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
A8MZ59

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired-like homeodomain transcription factor LEUTX
Alternative name(s):
Leucine-twenty homeobox
Paired-like homeobox transcription factor LEUTX1 Publication
Short name:
PRD-LIKE homeobox transcription factor LEUTX1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LEUTXImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000213921.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31953, LEUTX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618701, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MZ59

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54I → T: Increased transcriptional activity; when associated with Ala-61-Val, restores wild-type transcriptional activity. 1 Publication1
Mutagenesisi61A → V: Abolished catalytic activity; when assiociated with Ile-54-Thr, restores wild-type transcriptional activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
342900

Open Targets

More...
OpenTargetsi
ENSG00000213921

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
A8MZ59, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LEUTX

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003438911 – 198Paired-like homeodomain transcription factor LEUTXAdd BLAST198

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MZ59

PRoteomics IDEntifications database

More...
PRIDEi
A8MZ59

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2455

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During early embryo development, its expression is restricted to the 4-cell to 8-cell stage of the preimplantation embryo.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213921, Expressed in monocyte and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MZ59, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000213921, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
A8MZ59
With#Exp.IntAct
AGPAT4 [Q9NRZ5]3EBI-17490413,EBI-1754287
AIG1 - isoform 2 [Q9NVV5-2]3EBI-17490413,EBI-11957045
AQP2 [P41181]3EBI-17490413,EBI-12701138
AQP3 [Q92482]3EBI-17490413,EBI-2808854
ASGR1 [P07306]3EBI-17490413,EBI-1172335
C1QL4 [Q86Z23]3EBI-17490413,EBI-12062109
CDS2 [O95674]3EBI-17490413,EBI-3913685
CMTM3 [Q96MX0]3EBI-17490413,EBI-7247651
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-17490413,EBI-11522780
CNIH1 [O95406]3EBI-17490413,EBI-12172273
CNIH3 [Q8TBE1]3EBI-17490413,EBI-12208021
CXCL9 [Q07325]3EBI-17490413,EBI-3911467
EMP3 [P54852]3EBI-17490413,EBI-3907816
ENTPD3 - isoform 2 [O75355-2]3EBI-17490413,EBI-12279764
FAM24B [Q8N5W8]3EBI-17490413,EBI-13383724
FZD7 [O75084]3EBI-17490413,EBI-746917
GOSR2 [O14653]3EBI-17490413,EBI-4401517
KIR2DL3 [P43628]3EBI-17490413,EBI-8632435
LAT - isoform 2 [O43561-2]3EBI-17490413,EBI-8070286
MRPL57 [Q9BQC6]3EBI-17490413,EBI-1055359
MS4A1 [P11836]3EBI-17490413,EBI-2808234
NAPB [Q9H115]3EBI-17490413,EBI-3921185
NDRG4 - isoform 2 [Q9ULP0-2]3EBI-17490413,EBI-11978907
OLFM4 [Q6UX06]3EBI-17490413,EBI-2804156
PLP1 - isoform DM-20 [P60201-2]3EBI-17490413,EBI-12188331
PNLIPRP1 [P54315]3EBI-17490413,EBI-8652812
PRB1 [A5D903]3EBI-17490413,EBI-10173935
SLC13A3 [Q8WWT9]3EBI-17490413,EBI-12938720
SLC30A8 [Q8IWU4]3EBI-17490413,EBI-10262251
SLC41A2 [Q96JW4]3EBI-17490413,EBI-10290130
STATH [P02808]3EBI-17490413,EBI-738687
TF [P02787]3EBI-17490413,EBI-714319
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-17490413,EBI-10694905
TMEM147 [Q9BVK8]3EBI-17490413,EBI-348587
TMEM187 [Q14656]3EBI-17490413,EBI-13046724
TMEM254 [Q8TBM7]3EBI-17490413,EBI-11956809
TMEM60 [Q9H2L4]3EBI-17490413,EBI-2852148
TMEM97 [Q5BJF2]3EBI-17490413,EBI-12111910
TSPO [P30536]3EBI-17490413,EBI-6623146
TTMP [Q5BVD1]3EBI-17490413,EBI-10243654
TTPA [P49638]3EBI-17490413,EBI-10210710
UNC93B1 [Q9H1C4]3EBI-17490413,EBI-4401271
VAMP4 [O75379]3EBI-17490413,EBI-744953
ZFPL1 [O95159]3EBI-17490413,EBI-718439
ZNF646 [O15015]3EBI-17490413,EBI-745608

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A8MZ59, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380053

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A8MZ59, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 190LEUTX region1 PublicationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi125 – 1369aaTAD1 PublicationAdd BLAST12
Motifi153 – 1619aaTAD1 Publication9
Motifi163 – 1719aaTAD1 Publication9
Motifi178 – 1869aaTAD1 Publication9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The homeobox contain essential residues (Ile-54, Lys-57, Ala-61) for binding to the 5'-TAATCC-3' motif of the targe gene promoters.1 Publication
The homeobox is incomplete and cannot bind to the 36 bp motif found in the promoters of the target genes.1 Publication
The 9aaTAD motif is a conserved putative nine amino acid transactivation motifs in C-terminus of the LEUTX region.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2251, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183093

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_124748_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MZ59

Identification of Orthologs from Complete Genome Data

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OMAi
QRAKWKK

Database of Orthologous Groups

More...
OrthoDBi
1417936at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MZ59

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: A8MZ59-2) [UniParc]FASTAAdd to basket
Also known as: LEUTX.n1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFEGPRRYRR PRTRFLSKQL TALRELLEKT MHPSLATMGK LASKLQLDLS
60 70 80 90 100
VVKIWFKNQR AKWKRQQRQQ MQTRPSLGPA NQTTSVKKEE TPSAITTANI
110 120 130 140 150
RPVSPGISDA NDHDLREPSG IKNPGGASAS ARVSSWDSQS YDIEQICLGA
160 170 180 190
SNPPWASTLF EIDEFVKIYD LPGEDDTSSL NQYLFPVCLE YDQLQSSV
Length:198
Mass (Da):22,358
Last modified:April 22, 2020 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF9D921B42E6ED11F
GO
Isoform 2 (identifier: A8MZ59-1) [UniParc]FASTAAdd to basket
Also known as: LEUTX.R

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:168
Mass (Da):18,626
Checksum:i400324258F92BEAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103V → E in DY655817 (Ref. 3) Curated1
Sequence conflicti128S → T in DY655817 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0605671 – 30Missing in isoform 2. Add BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005393 Genomic DNA No translation available.
CR746510 mRNA No translation available.
DY655817 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001137304.1, NM_001143832.1 [A8MZ59-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396841; ENSP00000380053; ENSG00000213921 [A8MZ59-1]
ENST00000629267; ENSP00000486698; ENSG00000280774 [A8MZ59-1]
ENST00000638280; ENSP00000491740; ENSG00000213921 [A8MZ59-2]
ENST00000640845; ENSP00000491781; ENSG00000280774 [A8MZ59-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
342900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:342900

UCSC genome browser

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UCSCi
uc010xvg.3, human [A8MZ59-2]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005393 Genomic DNA No translation available.
CR746510 mRNA No translation available.
DY655817 mRNA No translation available.
RefSeqiNP_001137304.1, NM_001143832.1 [A8MZ59-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA8MZ59, 45 interactors
STRINGi9606.ENSP00000380053

Polymorphism and mutation databases

BioMutaiLEUTX

Proteomic databases

PaxDbiA8MZ59
PRIDEiA8MZ59
ProteomicsDBi2455

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48021, 8 antibodies

Genome annotation databases

EnsembliENST00000396841; ENSP00000380053; ENSG00000213921 [A8MZ59-1]
ENST00000629267; ENSP00000486698; ENSG00000280774 [A8MZ59-1]
ENST00000638280; ENSP00000491740; ENSG00000213921 [A8MZ59-2]
ENST00000640845; ENSP00000491781; ENSG00000280774 [A8MZ59-2]
GeneIDi342900
KEGGihsa:342900
UCSCiuc010xvg.3, human [A8MZ59-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
342900
DisGeNETi342900
EuPathDBiHostDB:ENSG00000213921.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LEUTX
HGNCiHGNC:31953, LEUTX
HPAiENSG00000213921, Not detected
MIMi618701, gene
neXtProtiNX_A8MZ59
OpenTargetsiENSG00000213921

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiKOG2251, Eukaryota
GeneTreeiENSGT00950000183093
HOGENOMiCLU_124748_0_0_1
InParanoidiA8MZ59
OMAiQRAKWKK
OrthoDBi1417936at2759
PhylomeDBiA8MZ59

Enzyme and pathway databases

PathwayCommonsiA8MZ59

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
342900, 0 hits in 118 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
342900
PharosiA8MZ59, Tdark

Protein Ontology

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PROi
PR:A8MZ59
RNActiA8MZ59, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000213921, Expressed in monocyte and 4 other tissues
ExpressionAtlasiA8MZ59, baseline and differential

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEUTX_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MZ59
Secondary accession number(s): A0A1W2PQ33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: April 22, 2020
Last modified: August 12, 2020
This is version 95 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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