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Entry version 100 (08 May 2019)
Sequence version 2 (10 Jun 2008)
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Protein

Tetratricopeptide repeat protein 34

Gene

TTC34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 34
Short name:
TPR repeat protein 34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:34297 TTC34

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MYJ7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100287898

Open Targets

More...
OpenTargetsi
ENSG00000215912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162407211

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC34

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003412781 – 566Tetratricopeptide repeat protein 34Add BLAST566

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A8MYJ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MYJ7

PRoteomics IDEntifications database

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PRIDEi
A8MYJ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
2407

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8MYJ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215912 Expressed in 74 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MYJ7 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066832

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
939557, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383873

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati50 – 83TPR 1Add BLAST34
Repeati178 – 211TPR 2Add BLAST34
Repeati212 – 245TPR 3Add BLAST34
Repeati306 – 339TPR 4Add BLAST34
Repeati341 – 373TPR 5Add BLAST33
Repeati424 – 457TPR 6Add BLAST34
Repeati464 – 497TPR 7Add BLAST34
Repeati512 – 545TPR 8Add BLAST34

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IE0N Eukaryota
ENOG410ZKC0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003047

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154706

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MYJ7

Database of Orthologous Groups

More...
OrthoDBi
1024217at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MYJ7

TreeFam database of animal gene trees

More...
TreeFami
TF332803

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8MYJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQRSPRAGP SRAQGRREAA ETGGPTTQEG VACGVHQLAT LLMELDSEDE
60 70 80 90 100
ASRLLAADAL YRLGRLEETH KALLVALSRR PQAAPVLARL ALLQLRRGFF
110 120 130 140 150
YDANQLVKKL VQSGDTACLQ PTLDVFCHED RQLLQGHCHA RALAILRARP
160 170 180 190 200
GGADGRVHTK EAIAYLSLAI FAAGSQASES LLARARCYGF LGQKKTAMFD
210 220 230 240 250
FNTVLRAEPG NVQALCGRAL VHLALDQLQE AVDDIVSALK LGPGTVVPEL
260 270 280 290 300
RSLKPEAQAL ITQGLYSHCR ALLSQLPDTG APLEDKDTQG LLAVGEALIK
310 320 330 340 350
IDSGQPHWHL LLADILMAQG SYEEAGTHLE KALHRAPTSE AARARLGLLQ
360 370 380 390 400
LKKGDVPGAA RDLQSLAEVD APDLSCLLHL LEASERQSLA QAAAQEAGTL
410 420 430 440 450
LDAGQPRQAL GYCSLSVLAS GSSACHLRLR ATCLAELQEF GRALRDLDHV
460 470 480 490 500
LQEALGDGDL PRRAEDFCRQ GRLLLSLGDE AAAAGAFAQA LKLAPSLAQN
510 520 530 540 550
SLCRQPGRAP TARMFLLRGQ CCLEEQRHAE AWTAVESGLL VDPDHRGLKR
560
LKARIRREAS SGCWLQ
Length:566
Mass (Da):60,903
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6668E05E87DC3E73
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYW7A0A1C7CYW7_HUMAN
Tetratricopeptide repeat protein 34
TTC34
1,079Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL592464 Genomic DNA No translation available.
AL831784 Genomic DNA No translation available.
DN831537 mRNA No translation available.
DN831538 mRNA No translation available.
DY655627 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001229601.1, NM_001242672.1
XP_016855479.1, XM_016999990.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000611612; ENSP00000483029; ENSG00000275571
ENST00000637179; ENSP00000490537; ENSG00000215912

Database of genes from NCBI RefSeq genomes

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GeneIDi
100287898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100287898

UCSC genome browser

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UCSCi
uc021oey.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592464 Genomic DNA No translation available.
AL831784 Genomic DNA No translation available.
DN831537 mRNA No translation available.
DN831538 mRNA No translation available.
DY655627 mRNA No translation available.
RefSeqiNP_001229601.1, NM_001242672.1
XP_016855479.1, XM_016999990.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi939557, 1 interactor
STRINGi9606.ENSP00000383873

PTM databases

PhosphoSitePlusiA8MYJ7

Polymorphism and mutation databases

BioMutaiTTC34

Proteomic databases

jPOSTiA8MYJ7
PaxDbiA8MYJ7
PRIDEiA8MYJ7
ProteomicsDBi2407

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611612; ENSP00000483029; ENSG00000275571
ENST00000637179; ENSP00000490537; ENSG00000215912
GeneIDi100287898
KEGGihsa:100287898
UCSCiuc021oey.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100287898
DisGeNETi100287898

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTC34
HGNCiHGNC:34297 TTC34
HPAiHPA066832
neXtProtiNX_A8MYJ7
OpenTargetsiENSG00000215912
PharmGKBiPA162407211

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE0N Eukaryota
ENOG410ZKC0 LUCA
GeneTreeiENSGT00390000003047
HOGENOMiHOG000154706
InParanoidiA8MYJ7
OrthoDBi1024217at2759
PhylomeDBiA8MYJ7
TreeFamiTF332803

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100287898

Protein Ontology

More...
PROi
PR:A8MYJ7

Gene expression databases

BgeeiENSG00000215912 Expressed in 74 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiA8MYJ7 baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC34_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MYJ7
Secondary accession number(s): A8MXL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 8, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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