UniProtKB - A8MYJ1 (A8MYJ1_HUMAN)
Protein
Submitted name:
A-kinase anchor protein 13
Gene
AKAP13
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cAMP-dependent protein kinase activity Source: InterPro
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
GO - Biological processi
- intracellular signal transduction Source: InterPro
- regulation of Rho protein signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorARBA annotation |
Ligand | ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: A-kinase anchor protein 13Imported |
Gene namesi | Name:AKAP13Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170776.19 |
HGNCi | HGNC:371, AKAP13 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000170776, Expressed in tendon of biceps brachii and 252 other tissues |
ExpressionAtlasi | A8MYJ1, baseline and differential |
Genevisiblei | A8MYJ1, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 413 – 460 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 48 | |
Domaini | 615 – 812 | DHInterPro annotationAdd BLAST | 198 | |
Domaini | 852 – 954 | PHInterPro annotationAdd BLAST | 103 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 71 – 90 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 107 – 183 | DisorderedSequence analysisAdd BLAST | 77 | |
Regioni | 229 – 270 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 377 – 415 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1087 – 1123 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 1286 – 1434 | DisorderedSequence analysisAdd BLAST | 149 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 972 – 999 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 71 – 87 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 107 – 141 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 253 – 270 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 379 – 412 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 1099 – 1122 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1286 – 1310 | PolyampholyteSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1334 – 1353 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1365 – 1395 | PolarSequence analysisAdd BLAST | 31 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154146 |
HOGENOMi | CLU_002466_1_0_1 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR028852, AKAP13 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain |
PANTHERi | PTHR13944:SF18, PTHR13944:SF18, 1 hit |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
A8MYJ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYERHKRRYS LCDISKVDRT VDVVLLKINR ENWCTIEPCP DAASLLASKQ
60 70 80 90 100
SPECENFLDV GLGRECTSKQ GVLKRESGSD SDLFHSPSDD MDSIIFPKPE
110 120 130 140 150
EEHLACDITG SSSSTDDTAS LDRHSSHGSD VSLSQILKPN RSRDRQSLDG
160 170 180 190 200
FYSHGMGAEG RESESEPADP GDVEEEEMDS ITEVPANCSV LRSSMRSLSP
210 220 230 240 250
FRRHSWGPGK NAASDAEMNH RSFSLEGLTG GAGVGNKPSS SLEVSSANAE
260 270 280 290 300
ELRHPFSGEE RVDSLVSLSE EDLESDQREH RMFDQQICHR SKQQGFNYCT
310 320 330 340 350
SAISSPLTKS ISLMTISHPG LDNSRPFHST FHNTSANLTE SITEENYNFL
360 370 380 390 400
PHSPSKKDSE WKSGTKVSRT FSYIKNKMSS SKKSKEKEKE KDKIKEKEKD
410 420 430 440 450
SKDKEKDKKT VNGHTFSSIP VVGPISCSQC MKPFTNKDAY TCANCSAFVH
460 470 480 490 500
KGCRESLASC AKVKMKPKGS LQAHDTSSLP TVIMRNKPSQ PKERPRSAVL
510 520 530 540 550
LVDETATTPI FANRRSQQSV SLSKSVSIQN ITGVGNDENM SNTWKFLSHS
560 570 580 590 600
TDSLNKISKV NESTESLTDE GVGTDMNEGQ LLGDFEIESK QLEAESWSRI
610 620 630 640 650
IDSKFLKQQK KDVVKRQEVI YELMQTEFHH VRTLKIMSGV YSQGMMADLL
660 670 680 690 700
FEQQMVEKLF PCLDELISIH SQFFQRILER KKESLVDKSE KNFLIKRIGD
710 720 730 740 750
VLVNQFSGEN AERLKKTYGK FCGQHNQSVN YFKDLYAKDK RFQAFVKKKM
760 770 780 790 800
SSSVVRRLGI PECILLVTQR ITKYPVLFQR ILQCTKDNEV EQEDLAQSLS
810 820 830 840 850
LVKDVIGAVD SKVASYEKKV RLNEIYTKTD SKSIMRMKSG QMFAKEDLKR
860 870 880 890 900
KKLVRDGSVF LKNAAGRLKE VQAVLLTDIL VFLQEKDQKY IFASLDQKST
910 920 930 940 950
VISLKKLIVR EVAHEEKGLF LISMGMTDPE MVEVHASSKE ERNSWIQIIQ
960 970 980 990 1000
DTINTLNRDE DEGIPSENEE EKKMLDTRAR ELKEQLHQKD QKILLLLEEK
1010 1020 1030 1040 1050
EMIFRDMAEC STPLPEDCSP THSPRVLFRS NTEEALKGGP LMKSAINEVE
1060 1070 1080 1090 1100
ILQGLVSGNL GGTLGPTVSS PIEQDVVGPV SLPRRAETFG GFDSHQMNAS
1110 1120 1130 1140 1150
KGGEKEEGDD GQDLRRTESD SGLKKGGNAN LVFMLKRNSE QVVQSVVHLY
1160 1170 1180 1190 1200
ELLSALQGVV LQQDSYIEDQ KLVLSERALT RSLSRPSSLI EQEKQRSLEK
1210 1220 1230 1240 1250
QRQDLANLQK QQAQYLEEKR RREREWEARE RELREREALL AQREEEVQQG
1260 1270 1280 1290 1300
QQDLEKEREE LQQKKGTYQY DLERLRAAQK QLEREQEQLR REAERLSQRQ
1310 1320 1330 1340 1350
TERDLCQVSH PHTKLMRIPS FFPSPEEPPS PSAPSIAKSG SLDSELSVSP
1360 1370 1380 1390 1400
KRNSISRTHK DKGPFHILSS TSQTNKGPEG QSQAPASTSA STRLFGLTKP
1410 1420 1430
KEKKEKKKKN KTSRSQPGDG PASEVSAEGE EIFC
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ12802 | AKP13_HUMAN | A-kinase anchor protein 13 | AKAP13 BRX, HT31, LBC | 2,813 | Annotation score: | ||
A0A087WTD7 | A0A087WTD7_HUMAN | A-kinase anchor protein 13 | AKAP13 | 1,429 | Annotation score: | ||
A0A087WY36 | A0A087WY36_HUMAN | A-kinase anchor protein 13 | AKAP13 | 967 | Annotation score: | ||
A0A087WX73 | A0A087WX73_HUMAN | A-kinase anchor protein 13 | AKAP13 | 166 | Annotation score: | ||
H0YMW2 | H0YMW2_HUMAN | A-kinase anchor protein 13 | AKAP13 | 1,745 | Annotation score: | ||
H0YLH1 | H0YLH1_HUMAN | A-kinase anchor protein 13 | AKAP13 | 275 | Annotation score: | ||
H0YK84 | H0YK84_HUMAN | A-kinase anchor protein 13 | AKAP13 | 146 | Annotation score: | ||
A0A087WYS7 | A0A087WYS7_HUMAN | A-kinase anchor protein 13 | AKAP13 | 66 | Annotation score: | ||
H0YK18 | H0YK18_HUMAN | A-kinase anchor protein 13 | AKAP13 | 93 | Annotation score: | ||
H0YMI5 | H0YMI5_HUMAN | A-kinase anchor protein 13 | AKAP13 | 38 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021739 Genomic DNA No translation available. AC087286 Genomic DNA No translation available. AC104046 Genomic DNA No translation available. AC110592 Genomic DNA No translation available. KC877559 Genomic DNA No translation available. KC877571 Genomic DNA No translation available. |
RefSeqi | NP_001257475.1, NM_001270546.1 |
Genome annotation databases
Ensembli | ENST00000394510; ENSP00000378018; ENSG00000170776 |
GeneIDi | 11214 |
UCSCi | uc031qtl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021739 Genomic DNA No translation available. AC087286 Genomic DNA No translation available. AC104046 Genomic DNA No translation available. AC110592 Genomic DNA No translation available. KC877559 Genomic DNA No translation available. KC877571 Genomic DNA No translation available. |
RefSeqi | NP_001257475.1, NM_001270546.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A8MYJ1 |
PRIDEi | A8MYJ1 |
ProteomicsDBi | 2405 |
Protocols and materials databases
Antibodypediai | 15576, 187 antibodies |
Genome annotation databases
Ensembli | ENST00000394510; ENSP00000378018; ENSG00000170776 |
GeneIDi | 11214 |
UCSCi | uc031qtl.1, human |
Organism-specific databases
CTDi | 11214 |
EuPathDBi | HostDB:ENSG00000170776.19 |
HGNCi | HGNC:371, AKAP13 |
OpenTargetsi | ENSG00000170776 |
PharmGKBi | PA24665 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154146 |
HOGENOMi | CLU_002466_1_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 11214, 9 hits in 848 CRISPR screens |
ChiTaRSi | AKAP13, human |
GenomeRNAii | 11214 |
Gene expression databases
Bgeei | ENSG00000170776, Expressed in tendon of biceps brachii and 252 other tissues |
ExpressionAtlasi | A8MYJ1, baseline and differential |
Genevisiblei | A8MYJ1, HS |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR028852, AKAP13 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR041020, PH_16 IPR001849, PH_domain |
PANTHERi | PTHR13944:SF18, PTHR13944:SF18, 1 hit |
Pfami | View protein in Pfam PF17838, PH_16, 1 hit PF00621, RhoGEF, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A8MYJ1_HUMAN | |
Accessioni | A8MYJ1Primary (citable) accession number: A8MYJ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | October 29, 2014 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |