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Entry version 57 (08 May 2019)
Sequence version 3 (26 Nov 2014)
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Protein

Uncharacterized protein CXorf49

Gene

CXorf49

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Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein CXorf49Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXorf49Imported
AND
Name:CXorf49BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30891 CXorf49
HGNC:34229 CXorf49B

neXtProt; the human protein knowledge platform

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neXtProti
NX_A8MYA2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000215115

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CXorf49

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003438951 – 514Uncharacterized protein CXorf49Add BLAST514

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
A8MYA2

ProteomicsDB human proteome resource

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ProteomicsDBi
2386

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
A8MYA2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
A8MYA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000215113 Expressed in 33 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
9606.ENSP00000482270

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A8MYA2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi303 – 308Poly-Ala6

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000015252

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A8MYA2

Identification of Orthologs from Complete Genome Data

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OMAi
FPSWGQR

Database of Orthologous Groups

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OrthoDBi
756568at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027822 DUF4641

The PANTHER Classification System

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PANTHERi
PTHR31866 PTHR31866, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15483 DUF4641, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A8MYA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSPDKVSVC GAGFDLEGGK KAGSRTASPG APGAHSHGLD LGVPGSGDGK
60 70 80 90 100
SESGFTDPEG FSFESESELI EQGRVVLWGR EGRPGTPVDD QGDVVDYSFY
110 120 130 140 150
LADEPAAIVP PPSVQGHPFP EGAAAEGSAE NWADAEVGPS GRDVLGHSPG
160 170 180 190 200
KWQQASAGRL HLCGPGPVRA WKNPERGSKS RWSLRVDPQQ PSAKGPTRLP
210 220 230 240 250
THDSDSADES SDLPLMKVGI CRNEGSQAKP GSPKKRADTS RQASFHCKES
260 270 280 290 300
YLPVPGRFLT SAPRGLTPVA ERPAVGELED SPQKKMQSRA WGKVEVRPSC
310 320 330 340 350
SGAAAAGALP QGLSRRKMAG GKKSLGGASQ LALGRGFPAC GERLSAAPPE
360 370 380 390 400
PATFPPFSGV RPQGMSKKPQ KPKHSSPGKK PAGRKTRESQ AAAREDNDPN
410 420 430 440 450
RDEVPRAQLP THRPGLPRLS VRRGEFSSSD PNIRAPQLPG TSEPSAYSPG
460 470 480 490 500
GLVPRRHAPS GNQQPPVHPP RPERQQQPPG AQGCPRCIWL QREIEDLTQQ
510
LAAMQFLTDK FQDL
Length:514
Mass (Da):54,417
Last modified:November 26, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20C31FDC3E87C618
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX276092 Genomic DNA No translation available.
BI827666 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS75991.1
CCDS75992.1

NCBI Reference Sequences

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RefSeqi
NP_001138611.1, NM_001145139.1
NP_001138612.1, NM_001145140.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000535490; ENSP00000480355; ENSG00000215115
ENST00000542739; ENSP00000482270; ENSG00000215113

Database of genes from NCBI RefSeq genomes

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GeneIDi
100130361
100132994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100130361
hsa:100132994

UCSC genome browser

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UCSCi
uc011mpy.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX276092 Genomic DNA No translation available.
BI827666 mRNA No translation available.
CCDSiCCDS75991.1
CCDS75992.1
RefSeqiNP_001138611.1, NM_001145139.1
NP_001138612.1, NM_001145140.1

3D structure databases

SMRiA8MYA2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000482270

PTM databases

iPTMnetiA8MYA2
PhosphoSitePlusiA8MYA2

Polymorphism and mutation databases

BioMutaiCXorf49

Proteomic databases

PRIDEiA8MYA2
ProteomicsDBi2386

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535490; ENSP00000480355; ENSG00000215115
ENST00000542739; ENSP00000482270; ENSG00000215113
GeneIDi100130361
100132994
KEGGihsa:100130361
hsa:100132994
UCSCiuc011mpy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
100130361
100132994

GeneCards: human genes, protein and diseases

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GeneCardsi
CXorf49
CXorf49B
HGNCiHGNC:30891 CXorf49
HGNC:34229 CXorf49B
neXtProtiNX_A8MYA2
OpenTargetsiENSG00000215115

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000015252
InParanoidiA8MYA2
OMAiFPSWGQR
OrthoDBi756568at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A8MYA2

Gene expression databases

BgeeiENSG00000215113 Expressed in 33 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR027822 DUF4641
PANTHERiPTHR31866 PTHR31866, 1 hit
PfamiView protein in Pfam
PF15483 DUF4641, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCX049_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MYA2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 26, 2014
Last modified: May 8, 2019
This is version 57 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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