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Protein

Keratin-associated protein 9-1

Gene

KRTAP9-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 9-1Curated
Alternative name(s):
Keratin-associated protein 9-like 3Imported
Gene namesi
Name:KRTAP9-1Imported
Synonyms:KAP9.1, KRTAP9.1, KRTAP9L3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000240542.4
HGNCiHGNC:18912 KRTAP9-1
neXtProtiNX_A8MXZ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939475

Polymorphism and mutation databases

BioMutaiKRTAP9-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003322611 – 250Keratin-associated protein 9-1Add BLAST250

Proteomic databases

PaxDbiA8MXZ3
PRIDEiA8MXZ3
ProteomicsDBi2365

PTM databases

iPTMnetiA8MXZ3
PhosphoSitePlusiA8MXZ3

Expressioni

Gene expression databases

BgeeiENSG00000240542 Expressed in 4 organ(s), highest expression level in skin of abdomen
ExpressionAtlasiA8MXZ3 baseline and differential

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

BioGridi608746, 1 interactor
STRINGi9606.ENSP00000381488

Structurei

3D structure databases

ProteinModelPortaliA8MXZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 1215
Repeati13 – 1725
Repeati18 – 2235
Repeati37 – 4145
Repeati42 – 4655
Repeati51 – 5565
Repeati56 – 6075
Repeati61 – 6585
Repeati66 – 7095
Repeati75 – 79105
Repeati80 – 84115
Repeati85 – 89125
Repeati90 – 94135
Repeati95 – 99145
Repeati105 – 109155
Repeati114 – 117164
Repeati118 – 121174
Repeati133 – 137185
Repeati138 – 142195
Repeati143 – 147205
Repeati153 – 157215
Repeati162 – 166225
Repeati167 – 171235
Repeati176 – 180245
Repeati185 – 189255
Repeati190 – 194265
Repeati214 – 218275
Repeati219 – 223285
Repeati229 – 233295
Repeati234 – 238305
Repeati239 – 243315
Repeati244 – 248325

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 24832 X 5 AA repeats of C-C-[CGSVRQH]-[SQTNP]-[PTSI]Add BLAST241

Sequence similaritiesi

Belongs to the KRTAP type 9 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KC5E Eukaryota
ENOG4111612 LUCA
GeneTreeiENSGT00890000139484
HOGENOMiHOG000234030
InParanoidiA8MXZ3
OMAiCCEEVTK
TreeFamiTF351356

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A8MXZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHCCSPCCQ PTCCRTTCCR TTCWKPTTVT TCSSTPCCQP SCCVPSCCQP
60 70 80 90 100
CCHPTCCQNT CCRTTCCQPT CVASCCQPSC CSTPCCQPTC CGSSCCGQTS
110 120 130 140 150
CGSSCCQPIC GSSCCQPCCH PTCYQTICFR TTCCQPTCCQ PTCCRNTSCQ
160 170 180 190 200
PTCCGSSCCQ PCCHPTCCQT ICRSTCCQPS CVTRCCSTPC CQPTCGGSSC
210 220 230 240 250
CSQTCNESSY CLPCCRPTCC QTTCYRTTCC RPSCCCSPCC VSSCCQPSCC
Length:250
Mass (Da):26,333
Last modified:December 4, 2007 - v1
Checksum:i38CEDE3EF8F2ACF2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQE7A0A0U1RQE7_HUMAN
Keratin-associated protein 9-1
KRTAP9-1
116Annotation score:
A0A0U1RR33A0A0U1RR33_HUMAN
Keratin-associated protein 9-1
KRTAP9-1
110Annotation score:
A0A0U1RQH2A0A0U1RQH2_HUMAN
Keratin-associated protein 9-1
KRTAP9-1
123Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006070 Genomic DNA No translation available.
CCDSiCCDS56029.1
RefSeqiNP_001177389.1, NM_001190460.1
UniGeneiHs.727478

Genome annotation databases

EnsembliENST00000398470; ENSP00000381488; ENSG00000240542
GeneIDi728318
KEGGihsa:728318
UCSCiuc021txf.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006070 Genomic DNA No translation available.
CCDSiCCDS56029.1
RefSeqiNP_001177389.1, NM_001190460.1
UniGeneiHs.727478

3D structure databases

ProteinModelPortaliA8MXZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608746, 1 interactor
STRINGi9606.ENSP00000381488

PTM databases

iPTMnetiA8MXZ3
PhosphoSitePlusiA8MXZ3

Polymorphism and mutation databases

BioMutaiKRTAP9-1

Proteomic databases

PaxDbiA8MXZ3
PRIDEiA8MXZ3
ProteomicsDBi2365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398470; ENSP00000381488; ENSG00000240542
GeneIDi728318
KEGGihsa:728318
UCSCiuc021txf.1 human

Organism-specific databases

CTDi728318
EuPathDBiHostDB:ENSG00000240542.4
GeneCardsiKRTAP9-1
HGNCiHGNC:18912 KRTAP9-1
neXtProtiNX_A8MXZ3
PharmGKBiPA134939475
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC5E Eukaryota
ENOG4111612 LUCA
GeneTreeiENSGT00890000139484
HOGENOMiHOG000234030
InParanoidiA8MXZ3
OMAiCCEEVTK
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

GenomeRNAii728318
PROiPR:A8MXZ3

Gene expression databases

BgeeiENSG00000240542 Expressed in 4 organ(s), highest expression level in skin of abdomen
ExpressionAtlasiA8MXZ3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKRA91_HUMAN
AccessioniPrimary (citable) accession number: A8MXZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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