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Protein

Nucleoside diphosphate-linked moiety X motif 19

Gene

NUDT19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).By similarity

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Magnesium or manganeseBy similarity1
Metal bindingi135Magnesium or manganeseBy similarity1

GO - Molecular functioni

  • acyl-CoA hydrolase activity Source: Reactome
  • metal ion binding Source: UniProtKB-KW
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-390918 Peroxisomal lipid metabolism
R-HSA-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate-linked moiety X motif 19 (EC:3.6.1.-)
Short name:
Nudix motif 19
Gene namesi
Name:NUDT19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213965.3
HGNCiHGNC:32036 NUDT19
neXtProtiNX_A8MXV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213965
PharmGKBiPA142671239

Polymorphism and mutation databases

BioMutaiNUDT19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245711 – 375Nucleoside diphosphate-linked moiety X motif 19Add BLAST375

Proteomic databases

EPDiA8MXV4
MaxQBiA8MXV4
PaxDbiA8MXV4
PRIDEiA8MXV4
ProteomicsDBi2356

PTM databases

iPTMnetiA8MXV4
PhosphoSitePlusiA8MXV4

Expressioni

Gene expression databases

BgeeiENSG00000213965 Expressed in 204 organ(s), highest expression level in adrenal gland
CleanExiHS_NUDT19
GenevisibleiA8MXV4 HS

Organism-specific databases

HPAiHPA042761

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi133735, 17 interactors
IntActiA8MXV4, 9 interactors
STRINGi9606.ENSP00000380251

Structurei

3D structure databases

ProteinModelPortaliA8MXV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 263Nudix hydrolasePROSITE-ProRule annotationAdd BLAST249

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi116 – 137Nudix boxAdd BLAST22
Motifi373 – 375Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG3904 Eukaryota
ENOG4111FKM LUCA
GeneTreeiENSGT00420000029858
HOGENOMiHOG000060163
HOVERGENiHBG017737
InParanoidiA8MXV4
KOiK13355
OMAiCDYNALL
OrthoDBiEOG091G0B8I
PhylomeDBiA8MXV4
TreeFamiTF313185

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR039121 NUDT19
PANTHERiPTHR12318 PTHR12318, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

A8MXV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSLRPGPS RWRRAASIVL AAGWSRPETA TPPSRPPPAE GFRLLLLQRS
60 70 80 90 100
PHQGFMPGAH VFSGGVLDAA DRSADWLGLF APHHGPPRFG LGPAPFSRTA
110 120 130 140 150
FPSLPDTDDH KTDNTGTLPE DVAFRICAVR EAFEEAGVLL LRPRTSPPGP
160 170 180 190 200
APGPGLALEP PPGLASWRDR VRQDPRHFLR LCAHLDCTPD IWALHNWSAW
210 220 230 240 250
LTPFLRGTTR RFDTAFFLCC LREPPPVYPD LAEVVGYQWS SPSEATESFL
260 270 280 290 300
SKEIWLPPPQ FYEVRRLANF ASLSDLHKFC LGRALEGLER WLPIILLTAD
310 320 330 340 350
GMVHLLPGDE LYLEDSDFLE NLMSTEKKTE EIMKEGKQFH RIVTYHRHLY
360 370
DIHVTVQPKY KHVYPKNSVV RKSHL
Length:375
Mass (Da):42,233
Last modified:December 4, 2007 - v1
Checksum:iD02AE72BE8615DA3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03983143R → Q. Corresponds to variant dbSNP:rs10413282Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008736 Genomic DNA No translation available.
CCDSiCCDS42543.1
RefSeqiNP_001099040.1, NM_001105570.1
UniGeneiHs.203961

Genome annotation databases

EnsembliENST00000397061; ENSP00000380251; ENSG00000213965
GeneIDi390916
KEGGihsa:390916
UCSCiuc010edf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008736 Genomic DNA No translation available.
CCDSiCCDS42543.1
RefSeqiNP_001099040.1, NM_001105570.1
UniGeneiHs.203961

3D structure databases

ProteinModelPortaliA8MXV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133735, 17 interactors
IntActiA8MXV4, 9 interactors
STRINGi9606.ENSP00000380251

PTM databases

iPTMnetiA8MXV4
PhosphoSitePlusiA8MXV4

Polymorphism and mutation databases

BioMutaiNUDT19

Proteomic databases

EPDiA8MXV4
MaxQBiA8MXV4
PaxDbiA8MXV4
PRIDEiA8MXV4
ProteomicsDBi2356

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397061; ENSP00000380251; ENSG00000213965
GeneIDi390916
KEGGihsa:390916
UCSCiuc010edf.3 human

Organism-specific databases

CTDi390916
EuPathDBiHostDB:ENSG00000213965.3
GeneCardsiNUDT19
HGNCiHGNC:32036 NUDT19
HPAiHPA042761
neXtProtiNX_A8MXV4
OpenTargetsiENSG00000213965
PharmGKBiPA142671239
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3904 Eukaryota
ENOG4111FKM LUCA
GeneTreeiENSGT00420000029858
HOGENOMiHOG000060163
HOVERGENiHBG017737
InParanoidiA8MXV4
KOiK13355
OMAiCDYNALL
OrthoDBiEOG091G0B8I
PhylomeDBiA8MXV4
TreeFamiTF313185

Enzyme and pathway databases

ReactomeiR-HSA-390918 Peroxisomal lipid metabolism
R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSiNUDT19 human
GenomeRNAii390916
PROiPR:A8MXV4

Gene expression databases

BgeeiENSG00000213965 Expressed in 204 organ(s), highest expression level in adrenal gland
CleanExiHS_NUDT19
GenevisibleiA8MXV4 HS

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR039121 NUDT19
PANTHERiPTHR12318 PTHR12318, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUD19_HUMAN
AccessioniPrimary (citable) accession number: A8MXV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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