GRXCR1

Functionⁱ

May play a role in actin filament architecture in developing stereocilia of sensory cells.By similarity

GO - Molecular functionⁱ

electron transfer activity Source: InterPro
protein disulfide oxidoreductase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
inner ear receptor cell development Source: UniProtKB
inner ear receptor cell stereocilium organization Source: UniProtKB
negative regulation of phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19389623
sensory perception of sound Source: UniProtKB
vestibular receptor cell development Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Hearing

Biological process

Hearing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutaredoxin domain-containing cysteine-rich protein 1
Gene namesⁱ	Name:GRXCR1 Synonyms:DFNB25
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000215203.2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31673 GRXCR1
MIMⁱ	613283 gene
neXtProtⁱ	NX_A8MXD5

Keywords - Cellular componentⁱ

Cell projection, Cilium

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Deafness, autosomal recessive, 25 (DFNB25)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of non-syndromic sensorineural deafness characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals, and vestibular dysfunction is observed in some affected individuals. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063160	38	P → L in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs367784906EnsemblClinVar.	1
Natural variantⁱVAR_063162	64	G → S in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs370551174Ensembl.	1
Natural variantⁱVAR_063164	138	R → C in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs267606856EnsemblClinVar.	1
Natural variantⁱVAR_063165	153	F → V in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs770874273Ensembl.	1

Keywords - Diseaseⁱ

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET More...DisGeNETⁱ	389207
MalaCards human disease database More...MalaCardsⁱ	GRXCR1
MIMⁱ	613285 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000215203
Orphanetⁱ	90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBⁱ	PA162390253

Polymorphism and mutation databases

BioMutaⁱ	GRXCR1

BioMutaⁱ

GRXCR1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000349189	1 – 290	Glutaredoxin domain-containing cysteine-rich protein 1Add BLAST		290

Proteomic databases

PaxDbⁱ	A8MXD5
PRIDEⁱ	A8MXD5
ProteomicsDBⁱ	2314

PTM databases

iPTMnetⁱ	A8MXD5
PhosphoSitePlusⁱ	A8MXD5

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000215203 Expressed in 8 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_GRXCR1

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040824

HPAⁱ

HPA040824

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	133037, 1 interactor
IntActⁱ	A8MXD5, 9 interactors
STRINGⁱ	9606.ENSP00000382670

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A8MXD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	127 – 234	GlutaredoxinPROSITE-ProRule annotationAdd BLAST		108

Sequence similaritiesⁱ

Belongs to the GRXCR1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2824 Eukaryota ENOG4111HAI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063827
HOGENOMⁱ	HOG000112811
HOVERGENⁱ	HBG095477
InParanoidⁱ	A8MXD5
KEGG Orthology (KO) More...KOⁱ	K17479
OMAⁱ	KALKCTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JWE
PhylomeDBⁱ	A8MXD5
TreeFamⁱ	TF315372

Family and domain databases

InterProⁱ	View protein in InterPro IPR002109 Glutaredoxin IPR036249 Thioredoxin-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00462 Glutaredoxin, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS51354 GLUTAREDOXIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A8MXD5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLKREMKPES DRPRKVRFRI ASSHSGRVLK EVYEDGQPSG SLDSECASIC 
        60         70         80         90        100
GIDGLGDSDG QQNGHIESEG DENENDQDSL LVLARAASEK GFGTRRVNIL 
       110        120        130        140        150
SKNGTVRGVK YKVSAGQALF NNLTKVLQQP STDLEFDRVV IYTTCLRVVR 
       160        170        180        190        200
TTFERCELVR KIFQNHRVKF EEKNIALNGE YGKELDERCR RVSEAPSLPV 
       210        220        230        240        250
VFIDGHYLGG AEKILSMNES GELQDILTKI ERVQHPHECP SCGGFGFLPC 
       260        270        280        290
SVCHGSKMSM FRNCFTDSFK ALKCTACNEN GLQRCKNCAG

Length:290

Mass (Da):32,294

Last modified:December 4, 2007 - v1

Checksum:ⁱ876595DDA9B9194B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063159	9	E → K1 PublicationCorresponds to variant dbSNP:rs78136490EnsemblClinVar.	1
Natural variantⁱVAR_063160	38	P → L in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs367784906EnsemblClinVar.	1
Natural variantⁱVAR_063161	51	G → E1 PublicationCorresponds to variant dbSNP:rs727505186EnsemblClinVar.	1
Natural variantⁱVAR_063162	64	G → S in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs370551174Ensembl.	1
Natural variantⁱVAR_063163	91	G → V2 PublicationsCorresponds to variant dbSNP:rs113203706EnsemblClinVar.	1
Natural variantⁱVAR_063164	138	R → C in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs267606856EnsemblClinVar.	1
Natural variantⁱVAR_063165	153	F → V in DFNB25. 1 PublicationCorresponds to variant dbSNP:rs770874273Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC098861 Genomic DNA No translation available. AC108035 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43225.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001073945.1, NM_001080476.2
UniGeneⁱ	Hs.162559

Genome annotation databases

Ensemblⁱ	ENST00000399770; ENSP00000382670; ENSG00000215203
GeneIDⁱ	389207
KEGGⁱ	hsa:389207
UCSC genome browser More...UCSCⁱ	uc003gwt.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A8MXD5	Glutaredoxin domain-containing cysteine-rich protein 1		MOUSE		290	UniRef90_Q50H32
Uncharacterized protein		MUSPF		354
glutaredoxin domain-containing cysteine-rich protein 1		Enhydra lutris kenyoni		314
glutaredoxin domain-containing cysteine-rich protein 1		ODORO		296
glutaredoxin domain-containing cysteine-rich protein 1		NEOSC		296
+101

Protein	Similar proteins		Species	Score	Length	Source
A8MXD5	Glutaredoxin domain-containing cysteine-rich protein 1		MOUSE		290	UniRef50_Q50H32
Uncharacterized protein		MUSPF		354
glutaredoxin domain-containing cysteine-rich protein 1		Enhydra lutris kenyoni		314
glutaredoxin domain-containing cysteine-rich protein 1		TARSY		296
Uncharacterized protein		RHIRO		296
+296

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC098861 Genomic DNA No translation available. AC108035 Genomic DNA No translation available.
CCDSⁱ	CCDS43225.1
RefSeqⁱ	NP_001073945.1, NM_001080476.2
UniGeneⁱ	Hs.162559

3D structure databases

ProteinModelPortalⁱ	A8MXD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	133037, 1 interactor
IntActⁱ	A8MXD5, 9 interactors
STRINGⁱ	9606.ENSP00000382670

PTM databases

iPTMnetⁱ	A8MXD5
PhosphoSitePlusⁱ	A8MXD5

Polymorphism and mutation databases

BioMutaⁱ	GRXCR1

BioMutaⁱ

GRXCR1

Proteomic databases

PaxDbⁱ	A8MXD5
PRIDEⁱ	A8MXD5
ProteomicsDBⁱ	2314

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	389207
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000399770; ENSP00000382670; ENSG00000215203
GeneIDⁱ	389207
KEGGⁱ	hsa:389207
UCSCⁱ	uc003gwt.4 human

Organism-specific databases

CTDⁱ	389207
DisGeNETⁱ	389207
EuPathDBⁱ	HostDB:ENSG00000215203.2
GeneCardsⁱ	GRXCR1
HGNCⁱ	HGNC:31673 GRXCR1
HPAⁱ	HPA040824
MalaCardsⁱ	GRXCR1
MIMⁱ	613283 gene 613285 phenotype
neXtProtⁱ	NX_A8MXD5
OpenTargetsⁱ	ENSG00000215203
Orphanetⁱ	90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBⁱ	PA162390253
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2824 Eukaryota ENOG4111HAI LUCA
GeneTreeⁱ	ENSGT00530000063827
HOGENOMⁱ	HOG000112811
HOVERGENⁱ	HBG095477
InParanoidⁱ	A8MXD5
KOⁱ	K17479
OMAⁱ	KALKCTS
OrthoDBⁱ	EOG091G0JWE
PhylomeDBⁱ	A8MXD5
TreeFamⁱ	TF315372

Miscellaneous databases

GeneWikiⁱ	GRXCR1
GenomeRNAiⁱ	389207
Protein Ontology More...PROⁱ	PR:A8MXD5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000215203 Expressed in 8 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_GRXCR1

Family and domain databases

InterProⁱ	View protein in InterPro IPR002109 Glutaredoxin IPR036249 Thioredoxin-like_sf
Pfamⁱ	View protein in Pfam PF00462 Glutaredoxin, 1 hit
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRCR1_HUMAN
Accessionⁱ	A8MXD5Primary (citable) accession number: A8MXD5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
	Last sequence update:	December 4, 2007
	Last modified:	November 7, 2018
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A8MXD5 (GRCR1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Glutaredoxin domain-containing cysteine-rich protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ