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Entry version 72 (05 Dec 2018)
Sequence version 3 (29 Oct 2014)
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Protein
Submitted name:

Myomesin-1

Gene

MYOM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myomesin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYOM1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101605.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7613 MYOM1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000101605

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A8MX12

PRoteomics IDEntifications database

More...
PRIDEi
A8MX12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101605 Expressed in 161 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MX12 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A8MX12

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 232Ig-likeInterPro annotationAdd BLAST92
Domaini260 – 362Ig-likeInterPro annotationAdd BLAST103
Domaini376 – 471Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini503 – 597Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini604 – 697Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini700 – 801Fibronectin type-IIIInterPro annotationAdd BLAST102
Domaini808 – 907Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini899 – 997Ig-likeInterPro annotationAdd BLAST99
Domaini1125 – 1211Ig-likeInterPro annotationAdd BLAST87
Domaini1351 – 1429Ig-likeInterPro annotationAdd BLAST79

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154982

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293283

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004977

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A8MX12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPIFSGRQK HVSGITDTEE ERIKEAAAYI AQRNLLASEE GITTSKQSTA
60 70 80 90 100
SKQTTASKQS TASKQSTASK QSTASRQSTA SRQSVVSKQA TSALQQEETS
110 120 130 140 150
EKKSRKVVIR EKAERLSLRK TLEETETYHA KLNEDHLLHA PEFIIKPRSH
160 170 180 190 200
TVWEKENVKL HCSIAGWPEP RVTWYKNQVP INVHANPGKY IIESRYGMHT
210 220 230 240 250
LEINGCDFED TAQYRASAMN VKGELSAYAS VVVKRYKGEF DETRFHAGAS
260 270 280 290 300
TMPLSFGVTP YGYASRFEIH FDDKFDVSFG REGETMSLGC RVVITPEIKH
310 320 330 340 350
FQPEIQWYRN GVPLSPSKWV QTLWSGERAT LTFSHLNKED EGLYTIRVRM
360 370 380 390 400
GEYYEQYSAY VFVRDADAEI EGAPAAPLDV KCLEANKDYI IISWKQPAVD
410 420 430 440 450
GGSPILGYFI DKCEVGTDSW SQCNDTPVKF ARFPVTGLIE GRSYIFRVRA
460 470 480 490 500
VNKMGIGFPS RVSEPVAALD PAEKARLKSP LSTLDWTIIV TEEEPSEGIV
510 520 530 540 550
PGPPTDLSVT EATRSYVVLS WKPPGQRGHE GIMYFVEKCE AGTENWQRVN
560 570 580 590 600
TELPVKSPRF ALFDLAEGKS YCFRVRCSNS AGVGEPSEAT EVTVVGDKLD
610 620 630 640 650
IPKAPGKIIP SRNTDTSVVV SWEESKDAKE LVGYYIEASV AGSGKWEPCN
660 670 680 690 700
NNPVKAHGFT CHGLVTGQSY IFRVRAVNAA GLSEYSQDSE AIEVKAAIAP
710 720 730 740 750
PSPPCDITCL ESFRDSMVLG WKQPDKIGGA EITGYYVNYR EVIDGVPGKW
760 770 780 790 800
REANVKAVSE EAYKISNLKE NMVYQFQVAA MNMAGLGAPS AVSECFKCEE
810 820 830 840 850
WTIAVPGPPH SLKCSEVRKD SLVLQWKPPV HSGRTPVTGY FVDLKEAKAK
860 870 880 890 900
EDQWRGLNEA AIKNVYLKVR GLKEGVSYVF RVRAINQAGV GKPSDLAGPV
910 920 930 940 950
VAETRPGTKE VVVNVDDDGV ISLNFECDKM TPKSEFSWSK DYVSTEDSPR
960 970 980 990 1000
LEVESKGNKT KMTFKDLGMD DLGIYSCDVT DTDGIASSYL IDEEELKRLL
1010 1020 1030 1040 1050
ALSHEHKFPT VPVKSELAVE ILEKGQVRFW MQAEKLSGNA KVNYIFNEKE
1060 1070 1080 1090 1100
IFEGPKYKMH IDRNTGIIEM FMEKLQDEDE GTYTFQLQDG KATNHSTVVL
1110 1120 1130 1140 1150
VGDVFKKLQK EAEFQRQEWI RKQGPHFVEY LSWEVTGECN VLLKCKVANI
1160 1170 1180 1190 1200
KKETHIVWYK DEREISVDEK HDFKDGICTL LITEFSKKDA GIYEVILKDD
1210 1220 1230 1240 1250
RGKDKSRLKL VDEAFKELMM EVCKKIALSA TDLKIQSTAE GIQLYSFVTY
1260 1270 1280 1290 1300
YVEDLKVNWS HNGSAIRYSD RVKTGVTGEQ IWLQINEPTP NDKGKYVMEL
1310 1320 1330 1340 1350
FDGKTGHQKT VDLSGQAYDE AYAEFQRLKQ AAIAEKNRAR VLGGLPDVVT
1360 1370 1380 1390 1400
IQEGKALNLT CNVWGDPPPE VSWLKNEKAL ASDDHCNLKF EAGRTAYFTI
1410 1420 1430 1440 1450
NGVSTADSGK YGLVVKNKYG SETSDFTVSV FIPEEEARMA ALESLKGGKK

AK
Length:1,452
Mass (Da):162,289
Last modified:October 29, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25805CDA8F58B901
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P52179MYOM1_HUMAN
Myomesin-1
MYOM1
1,685Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRK2J3KRK2_HUMAN
Myomesin-1
MYOM1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP005329 Genomic DNA No translation available.
AP005431 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400569; ENSP00000383413; ENSG00000101605

UCSC genome browser

More...
UCSCi
uc060mwz.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005329 Genomic DNA No translation available.
AP005431 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA8MX12
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA8MX12
PRIDEiA8MX12

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400569; ENSP00000383413; ENSG00000101605
UCSCiuc060mwz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000101605.12
HGNCiHGNC:7613 MYOM1
OpenTargetsiENSG00000101605

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154982
HOGENOMiHOG000293283
HOVERGENiHBG004977

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYOM1 human

Gene expression databases

BgeeiENSG00000101605 Expressed in 161 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiA8MX12 baseline and differential

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 5 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA8MX12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MX12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 4, 2007
Last sequence update: October 29, 2014
Last modified: December 5, 2018
This is version 72 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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