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UniProtKB - A8MWU7 (A8MWU7_HUMAN)
Protein
Submitted name:
Gamma-aminobutyric acid receptor subunit gamma-2
Gene
GABRG2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- extracellular ligand-gated ion channel activity Source: InterPro
- GABA-A receptor activity Source: InterPro
GO - Biological processi
- chloride transport Source: UniProtKB-KW
- gamma-aminobutyric acid signaling pathway Source: InterPro
Keywordsi
Molecular function | Chloride channelARBA annotation, Ion channel, ReceptorImported |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Submitted name: Gamma-aminobutyric acid receptor subunit gamma-2Submitted name: cDNA FLJ59748, highly similar to Gamma-aminobutyric-acid receptor gamma-2 subunitImported |
Gene namesi | Name:GABRG2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4087, GABRG2 |
VEuPathDBi | HostDB:ENSG00000113327 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- chloride channel complex Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 177 – 201 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 242 – 265 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 352 – 371 | HelicalUniRule annotationAdd BLAST | 20 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 95 ↔ 109 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, GlycoproteinARBA annotationProteomic databases
ProteomicsDBi | 2267 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 177 | Neur_chan_LBDInterPro annotationAdd BLAST | 177 | |
Domaini | 184 – 305 | Neur_chan_membInterPro annotationAdd BLAST | 122 |
Sequence similaritiesi
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156685 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR005437, GABRG-1/4 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01620, GABAARGAMMA PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
A8MWU7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYVNSIGPVN AINMEYTIDI FFAQTWYDRR LKFNSTIKVL RLNSNMVGKI
60 70 80 90 100
WIPDTFFRNS KKADAHWITT PNRMLRIWND GRVLYTLRLT IDAECQLQLH
110 120 130 140 150
NFPMDEHSCP LEFSSYGYPR EEIVYQWKRS SVEVGDTRSW RLYQFSFVGL
160 170 180 190 200
RNTTEVVKTT SGDYVVMSVY FDLSRRMGYF TIQTYIPCTL IVVLSWVSFW
210 220 230 240 250
INKDAVPART SLGITTVLTM TTLSTIARKS LPKVSYVTAM DLFVSVCFIF
260 270 280 290 300
VFSALVEYGT LHYFVSNRKP SKDKDKKKKN PAPTIDIRPR SATIQMNNAT
310 320 330 340 350
HLQERDEEYG YECLDGKDCA SFFCCFEDCR TGAWRHGRIH IRIAKMDSYA
360 370
RIFFPTAFCL FNLVYWVSYL YL
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP18507 | GBRG2_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 467 | Annotation score: | ||
A0A1W2PPN5 | A0A1W2PPN5_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 385 | Annotation score: | ||
A0A1W2PPS4 | A0A1W2PPS4_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 385 | Annotation score: | ||
A0A286YFI6 | A0A286YFI6_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 498 | Annotation score: | ||
A0A1X7SBS5 | A0A1X7SBS5_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 476 | Annotation score: | ||
A0A1X7SBZ8 | A0A1X7SBZ8_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 507 | Annotation score: | ||
A0A1W2PQX1 | A0A1W2PQX1_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 397 | Annotation score: | ||
A0A1W2PRN4 | A0A1W2PRN4_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 453 | Annotation score: | ||
A0A1W2PR49 | A0A1W2PR49_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 445 | Annotation score: | ||
A0A1W2PQR9 | A0A1W2PQR9_HUMAN | Gamma-aminobutyric acid receptor su... | GABRG2 | 446 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008611 Genomic DNA No translation available. AC091926 Genomic DNA No translation available. AC091984 Genomic DNA No translation available. AK299640 mRNA Translation: BAG61563.1 |
Genome annotation databases
Ensembli | ENST00000638552.1; ENSP00000491763.1; ENSG00000113327.17 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008611 Genomic DNA No translation available. AC091926 Genomic DNA No translation available. AC091984 Genomic DNA No translation available. AK299640 mRNA Translation: BAG61563.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 2267 |
Protocols and materials databases
Antibodypediai | 28585, 395 antibodies from 38 providers |
Genome annotation databases
Ensembli | ENST00000638552.1; ENSP00000491763.1; ENSG00000113327.17 |
Organism-specific databases
HGNCi | HGNC:4087, GABRG2 |
OpenTargetsi | ENSG00000113327 |
VEuPathDBi | HostDB:ENSG00000113327 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156685 |
Miscellaneous databases
ChiTaRSi | GABRG2, human |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR005437, GABRG-1/4 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00253, GABAARECEPTR PR01620, GABAARGAMMA PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A8MWU7_HUMAN | |
Accessioni | A8MWU7Primary (citable) accession number: A8MWU7 Secondary accession number(s): B4DSA1, C9JAR3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 4, 2007 |
Last sequence update: | June 28, 2011 | |
Last modified: | May 25, 2022 | |
This is version 105 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |