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Protein

PHD finger protein 20-like protein 1

Gene

PHF20L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri681 – 729PHD-typeAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 20-like protein 1
Gene namesi
Name:PHF20L1
ORF Names:CGI-72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000129292.20
HGNCiHGNC:24280 PHF20L1
neXtProtiNX_A8MW92

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi51105
OpenTargetsiENSG00000129292
PharmGKBiPA134874888

Polymorphism and mutation databases

BioMutaiPHF20L1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003360011 – 1017PHD finger protein 20-like protein 1Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei368PhosphoserineBy similarity1
Modified residuei433PhosphoserineCombined sources1
Cross-linki530Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki851Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiA8MW92
MaxQBiA8MW92
PaxDbiA8MW92
PRIDEiA8MW92
ProteomicsDBi2228
2229 [A8MW92-2]
2230 [A8MW92-4]

PTM databases

iPTMnetiA8MW92
PhosphoSitePlusiA8MW92

Expressioni

Gene expression databases

BgeeiENSG00000129292 Expressed in 212 organ(s), highest expression level in adrenal tissue
CleanExiHS_PHF20L1
ExpressionAtlasiA8MW92 baseline and differential
GenevisibleiA8MW92 HS

Organism-specific databases

HPAiHPA025060
HPA028417

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi119294, 36 interactors
IntActiA8MW92, 15 interactors
MINTiA8MW92
STRINGi9606.ENSP00000378784

Structurei

Secondary structure

11017
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliA8MW92
SMRiA8MW92
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA8MW92

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 71Tudor 1Add BLAST61
Domaini85 – 141Tudor 2Add BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 579Lys-richAdd BLAST50

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri681 – 729PHD-typeAdd BLAST49

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1844 Eukaryota
ENOG410YHG2 LUCA
GeneTreeiENSGT00390000006451
HOVERGENiHBG101874
InParanoidiA8MW92
KOiK18402
OMAiQDQGIAG
OrthoDBiEOG091G01T4
PhylomeDBiA8MW92
TreeFamiTF106475

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR014002 Agenet_dom_plant
IPR022255 DUF3776
IPR004092 Mbt
IPR002999 Tudor
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12618 DUF3776, 1 hit
PF02820 MBT, 1 hit
SMARTiView protein in SMART
SM00743 Agenet, 2 hits
SM00333 TUDOR, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A8MW92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKKPPNRPG ITFEIGARLE ALDYLQKWYP SRIEKIDYEE GKMLVHFERW
60 70 80 90 100
SHRYDEWIYW DSNRLRPLER PALRKEGLKD EEDFFDFKAG EEVLARWTDC
110 120 130 140 150
RYYPAKIEAI NKEGTFTVQF YDGVIRCLKR MHIKAMPEDA KGQVKSQHPL
160 170 180 190 200
SWCCPIDPAG SCNQSMGSED WIALVKAAAA AAAKNKTGSK PRTSANSNKD
210 220 230 240 250
KDKDERKWFK VPSKKEETST CIATPDVEKK EDLPTSSETF GLHVENVPKM
260 270 280 290 300
VFPQPESTLS NKRKNNQGNS FQAKRARLNK ITGLLASKAV GVDGAEKKED
310 320 330 340 350
YNETAPMLEQ AISPKPQSQK KNEADISSSA NTQKPALLSS TLSSGKARSK
360 370 380 390 400
KCKHESGDSS GCIKPPKSPL SPELIQVEDL TLVSQLSSSV INKTSPPQPV
410 420 430 440 450
NPPRPFKHSE RRRRSQRLAT LPMPDDSVEK VSSPSPATDG KVFSISSQNQ
460 470 480 490 500
QESSVPEVPD VAHLPLEKLG PCLPLDLSRG SEVTAPVASD SSYRNECPRA
510 520 530 540 550
EKEDTQMLPN PSSKAIADGR GAPAAAGISK TEKKVKLEDK SSTAFGKRKE
560 570 580 590 600
KDKERREKRD KDHYRPKQKK KKKKKKKSKQ HDYSDYEDSS LEFLERCSSP
610 620 630 640 650
LTRSSGSSLA SRSMFTEKTT TYQYPRAILS VDLSGENLSD VDFLDDSSTE
660 670 680 690 700
SLLLSGDEYN QDFDSTNFEE SQDEDDALNE IVRCICEMDE ENGFMIQCEE
710 720 730 740 750
CLCWQHSVCM GLLEESIPEQ YICYICRDPP GQRWSAKYRY DKEWLNNGRM
760 770 780 790 800
CGLSFFKENY SHLNAKKIVS THHLLADVYG VTEVLHGLQL KIGILKNKHH
810 820 830 840 850
PDLHLWACSG KRKDQDQIIA GVEKKIAQDT VNREEKKYVQ NHKEPPRLPL
860 870 880 890 900
KMEGTYITSE HSYQKPQSFG QDCKSLADPG SSDDDDVSSL EEEQEFHMRS
910 920 930 940 950
KNSLQYSAKE HGMPEKNPAE GNTVFVYNDK KGTEDPGDSH LQWQLNLLTH
960 970 980 990 1000
IENVQNEVTS RMDLIEKEVD VLESWLDFTG ELEPPDPLAR LPQLKRHIKQ
1010
LLIDMGKVQQ IATLCSV
Length:1,017
Mass (Da):115,010
Last modified:January 11, 2011 - v2
Checksum:i6FF33736EE712836
GO
Isoform 2 (identifier: A8MW92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-169: Missing.
     311-311: A → V
     312-1017: Missing.

Show »
Length:285
Mass (Da):32,825
Checksum:iAFD021E8921F4E0E
GO
Isoform 4 (identifier: A8MW92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-573: KRKEKDKERREKRDKDHYRPKQKKKKK → IRSWDFSALLMKIPSYSPISLSGLPES
     574-1017: Missing.

Show »
Length:573
Mass (Da):63,487
Checksum:i71094E5C08D97D0D
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS0A0A0A0MQS0_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
991Annotation score:
F8W9L8F8W9L8_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
992Annotation score:
A8MUE8A8MUE8_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
311Annotation score:
A8MXR8A8MXR8_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
316Annotation score:
E9PM57E9PM57_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
264Annotation score:
A0A0D9SG14A0A0D9SG14_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
160Annotation score:
H0YC05H0YC05_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
112Annotation score:
E5RK91E5RK91_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
86Annotation score:
H0YDF7H0YDF7_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
93Annotation score:

Sequence cautioni

The sequence AAD34067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP33690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15098 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW92152 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033781144 – 169Missing in isoform 2. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_033782311A → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_033783312 – 1017Missing in isoform 2. 2 PublicationsAdd BLAST706
Alternative sequenceiVSP_040407547 – 573KRKEK…KKKKK → IRSWDFSALLMKIPSYSPIS LSGLPES in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_040408574 – 1017Missing in isoform 4. 1 PublicationAdd BLAST444

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025268 mRNA Translation: BAB15098.1 Different initiation.
AK290506 mRNA Translation: BAF83195.1
AF228727 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92148.1
CH471060 Genomic DNA Translation: EAW92152.1 Sequence problems.
BC015211 mRNA Translation: AAH15211.1
BC050655 mRNA Translation: AAH50655.4
BC056413 mRNA Translation: AAH56413.2
AF151830 mRNA Translation: AAD34067.1 Different initiation.
AY279109 mRNA Translation: AAP33690.1 Different initiation.
CCDSiCCDS6367.2 [A8MW92-1]
CCDS6368.1 [A8MW92-2]
RefSeqiNP_057102.4, NM_016018.4 [A8MW92-1]
NP_940915.1, NM_198513.1 [A8MW92-2]
XP_016869006.1, XM_017013517.1 [A8MW92-2]
UniGeneiHs.304362

Genome annotation databases

EnsembliENST00000337920; ENSP00000338269; ENSG00000129292 [A8MW92-2]
ENST00000395386; ENSP00000378784; ENSG00000129292 [A8MW92-1]
ENST00000622263; ENSP00000482945; ENSG00000129292 [A8MW92-1]
GeneIDi51105
KEGGihsa:51105
UCSCiuc003ytr.4 human [A8MW92-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025268 mRNA Translation: BAB15098.1 Different initiation.
AK290506 mRNA Translation: BAF83195.1
AF228727 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92148.1
CH471060 Genomic DNA Translation: EAW92152.1 Sequence problems.
BC015211 mRNA Translation: AAH15211.1
BC050655 mRNA Translation: AAH50655.4
BC056413 mRNA Translation: AAH56413.2
AF151830 mRNA Translation: AAD34067.1 Different initiation.
AY279109 mRNA Translation: AAP33690.1 Different initiation.
CCDSiCCDS6367.2 [A8MW92-1]
CCDS6368.1 [A8MW92-2]
RefSeqiNP_057102.4, NM_016018.4 [A8MW92-1]
NP_940915.1, NM_198513.1 [A8MW92-2]
XP_016869006.1, XM_017013517.1 [A8MW92-2]
UniGeneiHs.304362

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQMNMR-A1-81[»]
2EQUNMR-A85-177[»]
2JTFNMR-A1-74[»]
ProteinModelPortaliA8MW92
SMRiA8MW92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119294, 36 interactors
IntActiA8MW92, 15 interactors
MINTiA8MW92
STRINGi9606.ENSP00000378784

PTM databases

iPTMnetiA8MW92
PhosphoSitePlusiA8MW92

Polymorphism and mutation databases

BioMutaiPHF20L1

Proteomic databases

EPDiA8MW92
MaxQBiA8MW92
PaxDbiA8MW92
PRIDEiA8MW92
ProteomicsDBi2228
2229 [A8MW92-2]
2230 [A8MW92-4]

Protocols and materials databases

DNASUi51105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337920; ENSP00000338269; ENSG00000129292 [A8MW92-2]
ENST00000395386; ENSP00000378784; ENSG00000129292 [A8MW92-1]
ENST00000622263; ENSP00000482945; ENSG00000129292 [A8MW92-1]
GeneIDi51105
KEGGihsa:51105
UCSCiuc003ytr.4 human [A8MW92-1]

Organism-specific databases

CTDi51105
DisGeNETi51105
EuPathDBiHostDB:ENSG00000129292.20
GeneCardsiPHF20L1
H-InvDBiHIX0007796
HGNCiHGNC:24280 PHF20L1
HPAiHPA025060
HPA028417
neXtProtiNX_A8MW92
OpenTargetsiENSG00000129292
PharmGKBiPA134874888
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1844 Eukaryota
ENOG410YHG2 LUCA
GeneTreeiENSGT00390000006451
HOVERGENiHBG101874
InParanoidiA8MW92
KOiK18402
OMAiQDQGIAG
OrthoDBiEOG091G01T4
PhylomeDBiA8MW92
TreeFamiTF106475

Miscellaneous databases

ChiTaRSiPHF20L1 human
EvolutionaryTraceiA8MW92
GenomeRNAii51105
PROiPR:A8MW92

Gene expression databases

BgeeiENSG00000129292 Expressed in 212 organ(s), highest expression level in adrenal tissue
CleanExiHS_PHF20L1
ExpressionAtlasiA8MW92 baseline and differential
GenevisibleiA8MW92 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR014002 Agenet_dom_plant
IPR022255 DUF3776
IPR004092 Mbt
IPR002999 Tudor
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12618 DUF3776, 1 hit
PF02820 MBT, 1 hit
SMARTiView protein in SMART
SM00743 Agenet, 2 hits
SM00333 TUDOR, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP20L1_HUMAN
AccessioniPrimary (citable) accession number: A8MW92
Secondary accession number(s): A8MZC9
, Q86U89, Q86W43, Q96BT0, Q9H702, Q9HBK3, Q9NYR3, Q9Y381
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 11, 2011
Last modified: October 10, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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