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Entry version 99 (08 May 2019)
Sequence version 2 (11 Jan 2011)
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Protein

PHD finger protein 20-like protein 1

Gene

PHF20L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri681 – 729PHD-typeAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PHD finger protein 20-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHF20L1
ORF Names:CGI-72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24280 PHF20L1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A8MW92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51105

Open Targets

More...
OpenTargetsi
ENSG00000129292

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134874888

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHF20L1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003360011 – 1017PHD finger protein 20-like protein 1Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei368PhosphoserineBy similarity1
Modified residuei433PhosphoserineCombined sources1
Cross-linki530Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki851Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A8MW92

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A8MW92

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A8MW92

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A8MW92

PRoteomics IDEntifications database

More...
PRIDEi
A8MW92

ProteomicsDB human proteome resource

More...
ProteomicsDBi
2228
2229 [A8MW92-2]
2230 [A8MW92-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A8MW92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A8MW92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129292 Expressed in 212 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A8MW92 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A8MW92 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA025060
HPA028417

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119294, 37 interactors

Protein interaction database and analysis system

More...
IntActi
A8MW92, 15 interactors

Molecular INTeraction database

More...
MINTi
A8MW92

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378784

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11017
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQMNMR-A1-81[»]
2EQUNMR-A85-177[»]
2JTFNMR-A1-74[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A8MW92

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A8MW92

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 71Tudor 1Add BLAST61
Domaini85 – 141Tudor 2Add BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi530 – 579Lys-richAdd BLAST50

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri681 – 729PHD-typeAdd BLAST49

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1844 Eukaryota
ENOG410YHG2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156215

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A8MW92

KEGG Orthology (KO)

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KOi
K18402

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRSMFTE

Database of Orthologous Groups

More...
OrthoDBi
147824at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A8MW92

TreeFam database of animal gene trees

More...
TreeFami
TF106475

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014002 Agenet_dom_plant
IPR022255 DUF3776
IPR040477 KDM4_Tudor_2
IPR004092 Mbt
IPR002999 Tudor
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12618 DUF3776, 1 hit
PF02820 MBT, 1 hit
PF18104 Tudor_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00743 Agenet, 2 hits
SM00333 TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01359 ZF_PHD_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A8MW92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKKPPNRPG ITFEIGARLE ALDYLQKWYP SRIEKIDYEE GKMLVHFERW
60 70 80 90 100
SHRYDEWIYW DSNRLRPLER PALRKEGLKD EEDFFDFKAG EEVLARWTDC
110 120 130 140 150
RYYPAKIEAI NKEGTFTVQF YDGVIRCLKR MHIKAMPEDA KGQVKSQHPL
160 170 180 190 200
SWCCPIDPAG SCNQSMGSED WIALVKAAAA AAAKNKTGSK PRTSANSNKD
210 220 230 240 250
KDKDERKWFK VPSKKEETST CIATPDVEKK EDLPTSSETF GLHVENVPKM
260 270 280 290 300
VFPQPESTLS NKRKNNQGNS FQAKRARLNK ITGLLASKAV GVDGAEKKED
310 320 330 340 350
YNETAPMLEQ AISPKPQSQK KNEADISSSA NTQKPALLSS TLSSGKARSK
360 370 380 390 400
KCKHESGDSS GCIKPPKSPL SPELIQVEDL TLVSQLSSSV INKTSPPQPV
410 420 430 440 450
NPPRPFKHSE RRRRSQRLAT LPMPDDSVEK VSSPSPATDG KVFSISSQNQ
460 470 480 490 500
QESSVPEVPD VAHLPLEKLG PCLPLDLSRG SEVTAPVASD SSYRNECPRA
510 520 530 540 550
EKEDTQMLPN PSSKAIADGR GAPAAAGISK TEKKVKLEDK SSTAFGKRKE
560 570 580 590 600
KDKERREKRD KDHYRPKQKK KKKKKKKSKQ HDYSDYEDSS LEFLERCSSP
610 620 630 640 650
LTRSSGSSLA SRSMFTEKTT TYQYPRAILS VDLSGENLSD VDFLDDSSTE
660 670 680 690 700
SLLLSGDEYN QDFDSTNFEE SQDEDDALNE IVRCICEMDE ENGFMIQCEE
710 720 730 740 750
CLCWQHSVCM GLLEESIPEQ YICYICRDPP GQRWSAKYRY DKEWLNNGRM
760 770 780 790 800
CGLSFFKENY SHLNAKKIVS THHLLADVYG VTEVLHGLQL KIGILKNKHH
810 820 830 840 850
PDLHLWACSG KRKDQDQIIA GVEKKIAQDT VNREEKKYVQ NHKEPPRLPL
860 870 880 890 900
KMEGTYITSE HSYQKPQSFG QDCKSLADPG SSDDDDVSSL EEEQEFHMRS
910 920 930 940 950
KNSLQYSAKE HGMPEKNPAE GNTVFVYNDK KGTEDPGDSH LQWQLNLLTH
960 970 980 990 1000
IENVQNEVTS RMDLIEKEVD VLESWLDFTG ELEPPDPLAR LPQLKRHIKQ
1010
LLIDMGKVQQ IATLCSV
Length:1,017
Mass (Da):115,010
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FF33736EE712836
GO
Isoform 2 (identifier: A8MW92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-169: Missing.
     311-311: A → V
     312-1017: Missing.

Show »
Length:285
Mass (Da):32,825
Checksum:iAFD021E8921F4E0E
GO
Isoform 4 (identifier: A8MW92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-573: KRKEKDKERREKRDKDHYRPKQKKKKK → IRSWDFSALLMKIPSYSPISLSGLPES
     574-1017: Missing.

Show »
Length:573
Mass (Da):63,487
Checksum:i71094E5C08D97D0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQS0A0A0A0MQS0_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
991Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9L8F8W9L8_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MUE8A8MUE8_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
311Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MXR8A8MXR8_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM57E9PM57_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
264Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG14A0A0D9SG14_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK91E5RK91_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC05H0YC05_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDF7H0YDF7_HUMAN
PHD finger protein 20-like protein ...
PHF20L1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAP33690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15098 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW92152 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033781144 – 169Missing in isoform 2. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_033782311A → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_033783312 – 1017Missing in isoform 2. 2 PublicationsAdd BLAST706
Alternative sequenceiVSP_040407547 – 573KRKEK…KKKKK → IRSWDFSALLMKIPSYSPIS LSGLPES in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_040408574 – 1017Missing in isoform 4. 1 PublicationAdd BLAST444

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK025268 mRNA Translation: BAB15098.1 Different initiation.
AK290506 mRNA Translation: BAF83195.1
AF228727 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92148.1
CH471060 Genomic DNA Translation: EAW92152.1 Sequence problems.
BC015211 mRNA Translation: AAH15211.1
BC050655 mRNA Translation: AAH50655.4
BC056413 mRNA Translation: AAH56413.2
AF151830 mRNA Translation: AAD34067.1 Different initiation.
AY279109 mRNA Translation: AAP33690.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6367.2 [A8MW92-1]
CCDS6368.1 [A8MW92-2]

NCBI Reference Sequences

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RefSeqi
NP_057102.4, NM_016018.4 [A8MW92-1]
NP_940915.1, NM_198513.1 [A8MW92-2]
XP_016869006.1, XM_017013517.1 [A8MW92-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000337920; ENSP00000338269; ENSG00000129292 [A8MW92-2]
ENST00000395386; ENSP00000378784; ENSG00000129292 [A8MW92-1]
ENST00000622263; ENSP00000482945; ENSG00000129292 [A8MW92-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51105

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51105

UCSC genome browser

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UCSCi
uc003ytr.4 human [A8MW92-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025268 mRNA Translation: BAB15098.1 Different initiation.
AK290506 mRNA Translation: BAF83195.1
AF228727 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92148.1
CH471060 Genomic DNA Translation: EAW92152.1 Sequence problems.
BC015211 mRNA Translation: AAH15211.1
BC050655 mRNA Translation: AAH50655.4
BC056413 mRNA Translation: AAH56413.2
AF151830 mRNA Translation: AAD34067.1 Different initiation.
AY279109 mRNA Translation: AAP33690.1 Different initiation.
CCDSiCCDS6367.2 [A8MW92-1]
CCDS6368.1 [A8MW92-2]
RefSeqiNP_057102.4, NM_016018.4 [A8MW92-1]
NP_940915.1, NM_198513.1 [A8MW92-2]
XP_016869006.1, XM_017013517.1 [A8MW92-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EQMNMR-A1-81[»]
2EQUNMR-A85-177[»]
2JTFNMR-A1-74[»]
SMRiA8MW92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119294, 37 interactors
IntActiA8MW92, 15 interactors
MINTiA8MW92
STRINGi9606.ENSP00000378784

PTM databases

iPTMnetiA8MW92
PhosphoSitePlusiA8MW92

Polymorphism and mutation databases

BioMutaiPHF20L1

Proteomic databases

EPDiA8MW92
jPOSTiA8MW92
MaxQBiA8MW92
PaxDbiA8MW92
PRIDEiA8MW92
ProteomicsDBi2228
2229 [A8MW92-2]
2230 [A8MW92-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337920; ENSP00000338269; ENSG00000129292 [A8MW92-2]
ENST00000395386; ENSP00000378784; ENSG00000129292 [A8MW92-1]
ENST00000622263; ENSP00000482945; ENSG00000129292 [A8MW92-1]
GeneIDi51105
KEGGihsa:51105
UCSCiuc003ytr.4 human [A8MW92-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51105
DisGeNETi51105

GeneCards: human genes, protein and diseases

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GeneCardsi
PHF20L1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0007796
HGNCiHGNC:24280 PHF20L1
HPAiHPA025060
HPA028417
neXtProtiNX_A8MW92
OpenTargetsiENSG00000129292
PharmGKBiPA134874888

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1844 Eukaryota
ENOG410YHG2 LUCA
GeneTreeiENSGT00940000156215
InParanoidiA8MW92
KOiK18402
OMAiPRSMFTE
OrthoDBi147824at2759
PhylomeDBiA8MW92
TreeFamiTF106475

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PHF20L1 human
EvolutionaryTraceiA8MW92

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51105

Protein Ontology

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PROi
PR:A8MW92

Gene expression databases

BgeeiENSG00000129292 Expressed in 212 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiA8MW92 baseline and differential
GenevisibleiA8MW92 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR014002 Agenet_dom_plant
IPR022255 DUF3776
IPR040477 KDM4_Tudor_2
IPR004092 Mbt
IPR002999 Tudor
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12618 DUF3776, 1 hit
PF02820 MBT, 1 hit
PF18104 Tudor_2, 1 hit
SMARTiView protein in SMART
SM00743 Agenet, 2 hits
SM00333 TUDOR, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP20L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A8MW92
Secondary accession number(s): A8MZC9
, Q86U89, Q86W43, Q96BT0, Q9H702, Q9HBK3, Q9NYR3, Q9Y381
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 11, 2011
Last modified: May 8, 2019
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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