Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM171A2

Gene

FAM171A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM171A2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161682.14
HGNCiHGNC:30480 FAM171A2
neXtProtiNX_A8MVW0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 315ExtracellularSequence analysisAdd BLAST286
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 826CytoplasmicSequence analysisAdd BLAST490

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161682
PharmGKBiPA162387197

Polymorphism and mutation databases

BioMutaiFAM171A2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000032877130 – 826Protein FAM171A2Add BLAST797

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei370PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei789PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiA8MVW0
MaxQBiA8MVW0
PaxDbiA8MVW0
PRIDEiA8MVW0
ProteomicsDBi2208

PTM databases

GlyConnecti1658
iPTMnetiA8MVW0
PhosphoSitePlusiA8MVW0
SwissPalmiA8MVW0

Expressioni

Gene expression databases

BgeeiENSG00000161682 Expressed in 100 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_FAM171A2
ExpressionAtlasiA8MVW0 baseline and differential
GenevisibleiA8MVW0 HS

Organism-specific databases

HPAiHPA019770

Interactioni

Protein-protein interaction databases

BioGridi129748, 32 interactors
IntActiA8MVW0, 1 interactor
STRINGi9606.ENSP00000293443

Structurei

3D structure databases

ProteinModelPortaliA8MVW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi474 – 480Poly-Pro7
Compositional biasi550 – 607Gly-richAdd BLAST58
Compositional biasi715 – 722Poly-Pro8

Sequence similaritiesi

Belongs to the FAM171 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC0 Eukaryota
ENOG410ZP57 LUCA
GeneTreeiENSGT00530000063318
HOGENOMiHOG000231925
HOVERGENiHBG057508
InParanoidiA8MVW0
OMAiYWVAAMA
OrthoDBiEOG091G01Y7
PhylomeDBiA8MVW0
TreeFamiTF331338

Family and domain databases

InterProiView protein in InterPro
IPR018890 Uncharacterised_FAM171
PANTHERiPTHR31626 PTHR31626, 1 hit
PfamiView protein in Pfam
PF10577 UPF0560, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A8MVW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPASGPSVL ARLLPLLGLL LGSASRAPGK SPPEPPSPQE ILIKVQVYVS
60 70 80 90 100
GELVPLARAS VDVFGNRTLL AAGTTDSEGV ATLPLSYRLG TWVLVTAARP
110 120 130 140 150
GFLTNSVPWR VDKLPLYASV SLYLLPERPA TLILYEDLVH ILLGSPGARS
160 170 180 190 200
QPLVQFQRRA ARLPVSSTYS QLWASLTPAS TQQEMRAFPA FLGTEASSSG
210 220 230 240 250
NGSWLELMPL TAVSVHLLTG NGTEVPLSGP IHLSLPVPSE TRALTVGTSI
260 270 280 290 300
PAWRFDPKSG LWVRNGTGVI RKEGRQLYWT FVSPQLGYWV AAMASPTAGL
310 320 330 340 350
VTITSGIQDI GTYHTIFLLT ILAALALLVL ILLCLLIYYC RRRCLKPRQQ
360 370 380 390 400
HRKLQLSGPS DGNKRDQATS MSQLHLICGG PLEPAPSGDP EAPPPGPLHS
410 420 430 440 450
AFSSSRDLAS SRDDFFRTKP RSASRPAAEP SGARGGESAG LKGARSAEGP
460 470 480 490 500
GGLEPGLEEH RRGPSGAAAF LHEPPSPPPP FDHYLGHKGA AEGKTPDFLL
510 520 530 540 550
SQSVDQLARP PSLGQAGQLI FCGSIDHLKD NVYRNVMPTL VIPAHYVRLG
560 570 580 590 600
GEAGAAGVGD EPAPPEGTAP GPARAFPQPD PQRPQMPGHS GPGGEGGGGG
610 620 630 640 650
GEGWGAGRAA PVSGSVTIPV LFNESTMAQL NGELQALTEK KLLELGVKPH
660 670 680 690 700
PRAWFVSLDG RSNSQVRHSY IDLQAGGGAR STDASLDSGV DVHEARPARR
710 720 730 740 750
RPAREERERA PPAAPPPPPA PPRLALSEDT EPSSSESRTG LCSPEDNSLT
760 770 780 790 800
PLLDEVAAPE GRAATVPRGR GRSRGDSSRS SASELRRDSL TSPEDELGAE
810 820
VGDEAGDKKS PWQRREERPL MVFNVK
Length:826
Mass (Da):87,435
Last modified:December 4, 2007 - v1
Checksum:i2845FC542702C3E0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMG4K7EMG4_HUMAN
Protein FAM171A2
FAM171A2
159Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003043 Genomic DNA No translation available.
CH471178 Genomic DNA Translation: EAW51598.1
CCDSiCCDS45701.1
RefSeqiNP_940877.2, NM_198475.2
UniGeneiHs.154001

Genome annotation databases

EnsembliENST00000293443; ENSP00000293443; ENSG00000161682
GeneIDi284069
KEGGihsa:284069
UCSCiuc002igs.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003043 Genomic DNA No translation available.
CH471178 Genomic DNA Translation: EAW51598.1
CCDSiCCDS45701.1
RefSeqiNP_940877.2, NM_198475.2
UniGeneiHs.154001

3D structure databases

ProteinModelPortaliA8MVW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129748, 32 interactors
IntActiA8MVW0, 1 interactor
STRINGi9606.ENSP00000293443

PTM databases

GlyConnecti1658
iPTMnetiA8MVW0
PhosphoSitePlusiA8MVW0
SwissPalmiA8MVW0

Polymorphism and mutation databases

BioMutaiFAM171A2

Proteomic databases

EPDiA8MVW0
MaxQBiA8MVW0
PaxDbiA8MVW0
PRIDEiA8MVW0
ProteomicsDBi2208

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293443; ENSP00000293443; ENSG00000161682
GeneIDi284069
KEGGihsa:284069
UCSCiuc002igs.3 human

Organism-specific databases

CTDi284069
EuPathDBiHostDB:ENSG00000161682.14
GeneCardsiFAM171A2
H-InvDBiHIX0013883
HGNCiHGNC:30480 FAM171A2
HPAiHPA019770
neXtProtiNX_A8MVW0
OpenTargetsiENSG00000161682
PharmGKBiPA162387197
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEC0 Eukaryota
ENOG410ZP57 LUCA
GeneTreeiENSGT00530000063318
HOGENOMiHOG000231925
HOVERGENiHBG057508
InParanoidiA8MVW0
OMAiYWVAAMA
OrthoDBiEOG091G01Y7
PhylomeDBiA8MVW0
TreeFamiTF331338

Miscellaneous databases

GenomeRNAii284069
PROiPR:A8MVW0

Gene expression databases

BgeeiENSG00000161682 Expressed in 100 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_FAM171A2
ExpressionAtlasiA8MVW0 baseline and differential
GenevisibleiA8MVW0 HS

Family and domain databases

InterProiView protein in InterPro
IPR018890 Uncharacterised_FAM171
PANTHERiPTHR31626 PTHR31626, 1 hit
PfamiView protein in Pfam
PF10577 UPF0560, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF1712_HUMAN
AccessioniPrimary (citable) accession number: A8MVW0
Secondary accession number(s): A8MQB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again