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Protein

Putative neutrophil cytosol factor 1C

Gene

NCF1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

May be required for activation of the latent NADPH oxidase (necessary for superoxide production).By similarity

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neutrophil cytosol factor 1C
Short name:
NCF-1C
Alternative name(s):
Putative SH3 and PX domain-containing protein 1C
Gene namesi
Name:NCF1C
Synonyms:SH3PXD1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32523 NCF1C
neXtProtiNX_A8MVU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi654817

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493681 – 366Putative neutrophil cytosol factor 1CAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279PhosphoserineBy similarity1
Modified residuei280PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei321PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA8MVU1
PRIDEiA8MVU1
ProteomicsDBi2205

Expressioni

Organism-specific databases

HPAiHPA047836
HPA052095

Structurei

3D structure databases

ProteinModelPortaliA8MVU1
SMRiA8MVU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 101PXPROSITE-ProRule annotationAdd BLAST101
Domaini132 – 191SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini202 – 261SH3 2PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IRR3 Eukaryota
ENOG410YYZE LUCA
HOVERGENiHBG002055
InParanoidiA8MVU1
PhylomeDBiA8MVU1

Family and domain databases

CDDicd12021 SH3_p47phox_1, 1 hit
cd12022 SH3_p47phox_2, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR015039 NADPH_oxidase_p47Phox_C
IPR035756 NCF1_SH3_1
IPR035757 NCF1_SH3_2
IPR032136 NECFESHC
IPR001655 P47PHOX
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15706:SF6 PTHR15706:SF6, 1 hit
PfamiView protein in Pfam
PF16621 NECFESHC, 1 hit
PF08944 p47_phox_C, 1 hit
PF00787 PX, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00498 P47PHOX
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

A8MVU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYMFLVKWQD LSEKVVYRRF TEIYEFHKTL KEMFPIEAGA INPENRIIPH
60 70 80 90 100
LPAPKWFDGQ RAAENHQGTL TEYCSTLMSL PTKISRCPHL LDFFKVRPDD
110 120 130 140 150
LKLPTDNQTK KPETYLMPKD GKSTATDITG PIILQTYRAI ADYEKTSGSE
160 170 180 190 200
MALSTGDVVE VVEKSESGWW FCQMKAKRGW IPASFLEPLD SPDETEDPEP
210 220 230 240 250
NYAGEPYVAI KAYTAVEGDE VSLLEGEAVE VIHKLLDGWW VIRKDDVTGY
260 270 280 290 300
FPSMYLQKSG QDVSQAQRQI KRGAPPRRSS IRNAHSIHQR SRKRLSQDAY
310 320 330 340 350
RRNSVRFLQQ RRRQARPGPQ SPGSPLEEER QTQRSKPQPA VPPRPSADLI
360
LNRCSESTKR KLASAV
Length:366
Mass (Da):41,851
Last modified:December 4, 2007 - v1
Checksum:i39CFA2C342102DB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124781 Genomic DNA No translation available.
UniGeneiHs.647047
Hs.648940
Hs.655201

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124781 Genomic DNA No translation available.
UniGeneiHs.647047
Hs.648940
Hs.655201

3D structure databases

ProteinModelPortaliA8MVU1
SMRiA8MVU1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA8MVU1
PRIDEiA8MVU1
ProteomicsDBi2205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi654817
GeneCardsiNCF1C
HGNCiHGNC:32523 NCF1C
HPAiHPA047836
HPA052095
neXtProtiNX_A8MVU1
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRR3 Eukaryota
ENOG410YYZE LUCA
HOVERGENiHBG002055
InParanoidiA8MVU1
PhylomeDBiA8MVU1

Family and domain databases

CDDicd12021 SH3_p47phox_1, 1 hit
cd12022 SH3_p47phox_2, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR015039 NADPH_oxidase_p47Phox_C
IPR035756 NCF1_SH3_1
IPR035757 NCF1_SH3_2
IPR032136 NECFESHC
IPR001655 P47PHOX
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15706:SF6 PTHR15706:SF6, 1 hit
PfamiView protein in Pfam
PF16621 NECFESHC, 1 hit
PF08944 p47_phox_C, 1 hit
PF00787 PX, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00498 P47PHOX
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNCF1C_HUMAN
AccessioniPrimary (citable) accession number: A8MVU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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